Establishment and characterization of a new human oestradiol- and progesterone-receptor-positive mammary carcinoma serially transplantable in nude mice
A human mammary carcinoma originating from a postmenopausal patient was successfully transplanted into nude mice. According to the adopted criteria the tumour proved to be oestradiol- and progesterone-receptor-positive. Histological studies of the patient tumour revealed a ductal invasive mammary ca...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 1992, Vol.119 (1), p.35-40 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | NAUNDORF, H FICHTNER, I BÜTTNER, B FREGE, J |
| description | A human mammary carcinoma originating from a postmenopausal patient was successfully transplanted into nude mice. According to the adopted criteria the tumour proved to be oestradiol- and progesterone-receptor-positive. Histological studies of the patient tumour revealed a ductal invasive mammary carcinoma with 80% tubular growth pattern. Following transplantation the adenoid structures decreased to 30%; the mitosis rate and grade of malignancy increased. Treatment of the nude mice with 20 micrograms oestradiol benzoate/mouse caused a loss of the oestradiol receptor of the mammary carcinoma. The mammary carcinoma 3366 can be used for testing of antineoplastic substances, antihormones and for studies in regard to down-regulation or blocking of hormone receptors and possible consequences for therapies. |
| doi_str_mv | 10.1007/BF01209485 |
| format | Article |
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Obstetrics ; Humans ; Mammary gland diseases ; Mammary Neoplasms, Experimental - metabolism ; Mammary Neoplasms, Experimental - pathology ; Medical sciences ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Receptors, Estradiol - metabolism ; Receptors, Progesterone - metabolism ; Transplantation, Heterologous ; Tumors</subject><ispartof>Journal of cancer research and clinical oncology, 1992, Vol.119 (1), p.35-40</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-c39d8f6364e56c1b00cf219eac6a1f03e507cb26a5ecb76c24b46c4f3f3f4b083</citedby><cites>FETCH-LOGICAL-c226t-c39d8f6364e56c1b00cf219eac6a1f03e507cb26a5ecb76c24b46c4f3f3f4b083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4396195$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1400563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAUNDORF, H</creatorcontrib><creatorcontrib>FICHTNER, I</creatorcontrib><creatorcontrib>BÜTTNER, B</creatorcontrib><creatorcontrib>FREGE, J</creatorcontrib><title>Establishment and characterization of a new human oestradiol- and progesterone-receptor-positive mammary carcinoma serially transplantable in nude mice</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><description>A human mammary carcinoma originating from a postmenopausal patient was successfully transplanted into nude mice. According to the adopted criteria the tumour proved to be oestradiol- and progesterone-receptor-positive. Histological studies of the patient tumour revealed a ductal invasive mammary carcinoma with 80% tubular growth pattern. Following transplantation the adenoid structures decreased to 30%; the mitosis rate and grade of malignancy increased. Treatment of the nude mice with 20 micrograms oestradiol benzoate/mouse caused a loss of the oestradiol receptor of the mammary carcinoma. The mammary carcinoma 3366 can be used for testing of antineoplastic substances, antihormones and for studies in regard to down-regulation or blocking of hormone receptors and possible consequences for therapies.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms</subject><subject>Cell Line</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Transplantation</subject><subject>Receptors, Estradiol - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Transplantation, Heterologous</subject><subject>Tumors</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EapeWC_dKPiAOSAF_Z3OEqqWVKnGh52gymbBGiR3shKr8Ef4uXnbVag7WeJ55Ne8MY2-l-CiFqD99uRZSicZs7Qu2kUarSmptX7KNkLWsrJLulL3O-acoua3VCTuRRgjr9Ib9vcoLdKPPu4nCwiH0HHeQABdK_g8sPgYeBw480APfrROUlPKSoPdxrP7zc4o_yhelGKhKhDQvMVVzzH7xv4lPME2QHjlCQh_iBDwXaRjHR15kQp5HCPsRiPvAw9qXDo90zl4NMGZ6c3zP2P311ffLm-ru29fby893FSrllgp1028Hp50h61B2QuCgZEOADuQgNFlRY6ccWMKudqhMZxyaQZcwndjqM_b-oFtc_FqLjXbyGWksQ1Fcc1trZZSQTQE_HEBMMedEQzsnvzfWStHur9A-X6HAF0fVtZuof0YPay_1d8c6ZIRxKHtAn58woxsnG6v_ATFpkrM</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>NAUNDORF, H</creator><creator>FICHTNER, I</creator><creator>BÜTTNER, B</creator><creator>FREGE, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Establishment and characterization of a new human oestradiol- and progesterone-receptor-positive mammary carcinoma serially transplantable in nude mice</title><author>NAUNDORF, H ; FICHTNER, I ; BÜTTNER, B ; FREGE, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-c39d8f6364e56c1b00cf219eac6a1f03e507cb26a5ecb76c24b46c4f3f3f4b083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms</topic><topic>Cell Line</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Mammary Neoplasms, Experimental - metabolism</topic><topic>Mammary Neoplasms, Experimental - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplasm Transplantation</topic><topic>Receptors, Estradiol - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Transplantation, Heterologous</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAUNDORF, H</creatorcontrib><creatorcontrib>FICHTNER, I</creatorcontrib><creatorcontrib>BÜTTNER, B</creatorcontrib><creatorcontrib>FREGE, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAUNDORF, H</au><au>FICHTNER, I</au><au>BÜTTNER, B</au><au>FREGE, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishment and characterization of a new human oestradiol- and progesterone-receptor-positive mammary carcinoma serially transplantable in nude mice</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>1992</date><risdate>1992</risdate><volume>119</volume><issue>1</issue><spage>35</spage><epage>40</epage><pages>35-40</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>A human mammary carcinoma originating from a postmenopausal patient was successfully transplanted into nude mice. According to the adopted criteria the tumour proved to be oestradiol- and progesterone-receptor-positive. Histological studies of the patient tumour revealed a ductal invasive mammary carcinoma with 80% tubular growth pattern. Following transplantation the adenoid structures decreased to 30%; the mitosis rate and grade of malignancy increased. Treatment of the nude mice with 20 micrograms oestradiol benzoate/mouse caused a loss of the oestradiol receptor of the mammary carcinoma. The mammary carcinoma 3366 can be used for testing of antineoplastic substances, antihormones and for studies in regard to down-regulation or blocking of hormone receptors and possible consequences for therapies.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>1400563</pmid><doi>10.1007/BF01209485</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of cancer research and clinical oncology, 1992, Vol.119 (1), p.35-40 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Breast Neoplasms Cell Line Estradiol - pharmacology Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Medical sciences Mice Mice, Nude Neoplasm Transplantation Receptors, Estradiol - metabolism Receptors, Progesterone - metabolism Transplantation, Heterologous Tumors |
| title | Establishment and characterization of a new human oestradiol- and progesterone-receptor-positive mammary carcinoma serially transplantable in nude mice |
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