Genetics of resistance to third‐generation cephalosporins in clinical isolates of Streptococcus pneumoniae

Summary Resistance to third‐generation cephalosporins in a clinical isolate of Streptococcus pneumoniae was shown to be due to the production of altered forms of penicillin‐binding proteins (PBPs) 2X and 1A. The cloned PBP2X gene from the resistant strain was able to transform a susceptible strain t...

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Veröffentlicht in:	Molecular microbiology 1992-09, Vol.6 (17), p.2461-2465
Hauptverfasser:	Muñoz, Rosario, Dowson, Christopher G., Daniels, Maggie, Coffey, Tracey J., Martin, Christiane, Hakenbeck, Regine, Spratt, Brian G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacteriology Biological and medical sciences Carrier Proteins - genetics Cephalosporins - pharmacology Cloning, Molecular DNA, Bacterial - genetics Drug Resistance, Microbial - genetics Fundamental and applied biological sciences. Psychology Genes, Bacterial - genetics Hexosyltransferases Microbiology Muramoylpentapeptide Carboxypeptidase - genetics Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Penicillin-Binding Proteins Peptidyl Transferases Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - genetics Transformation, Bacterial - genetics
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