The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high morbidity and mortality rates. The development of novel therapies for sepsis is critically dependent on an understanding of the basic mechanisms of the disease. The pathophysiology of severe sepsis involves a high...
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| Veröffentlicht in: | Blood 2003-05, Vol.101 (10), p.3765-3777 |
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| creator | Aird, William C. |
| description | Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high morbidity and mortality rates. The development of novel therapies for sepsis is critically dependent on an understanding of the basic mechanisms of the disease. The pathophysiology of severe sepsis involves a highly complex, integrated response that includes the activation of a number of cell types, inflammatory mediators, and the hemostatic system. Central to this process is an alteration of endothelial cell function. The goals of this article are to (1) provide an overview of sepsis and its complications, (2) discuss the role of the endothelium in orchestrating the host response in sepsis, and (3) emphasize the potential value of the endothelium as a target for sepsis therapy. |
| doi_str_mv | 10.1182/blood-2002-06-1887 |
| format | Article |
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Psychology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Microbiology</subject><subject>Molecular and cellular biology</subject><subject>Multiple Organ Failure - physiopathology</subject><subject>Sepsis - physiopathology</subject><subject>Sepsis - therapy</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhq2KChbKH-gB5UJvoeOPOI7EBSEKSEhctmfLsSetUWIvdoK0_x4vuxI3Tq81et6R5yHkJ4UrShX73Y8xupoBsBpkTZVqv5EVbZiqywiOyAqgzEXX0hNymvMLABWcNcfkhLJGcCW7FVmv_2OV4ohVHKq5vDG4WHL0y1T5UGV8w4QlNtnnygRXTcs4-82ukP6ZULltHpZgZx8LvA0uxQl_kO-DGTOeH_KM_P1zt759qJ-e7x9vb55qKzo210Ko1knTKdkDCFAgHAzclgt4y4Uw0omh4cx1wjDZYy97Q3nTsAF6iqXCz8iv_d5Niq8L5llPPlscRxMwLlm3nAlKhSwg24M2xZwTDnqT_GTSVlPQO5f6w6XeudQg9c5lKV0cti_9hO6zcpBXgMsDYLI145BMsD5_ckI1rP3grvccFhdvHpPO1mOw6HxCO2sX_Vf_eAdOFZHD</recordid><startdate>20030515</startdate><enddate>20030515</enddate><creator>Aird, William C.</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030515</creationdate><title>The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome</title><author>Aird, William C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-4487d6a986b0040804d0f3c15237344a6d4f532d94a26beb6ba13552f0b1eb003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Blood, 2003-05, Vol.101 (10), p.3765-3777 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Endothelium, Vascular - physiopathology Fundamental and applied biological sciences. Psychology General aspects Humans Inflammation Microbiology Molecular and cellular biology Multiple Organ Failure - physiopathology Sepsis - physiopathology Sepsis - therapy |
| title | The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome |
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