The Herbal Medicine Unkei-to Stimulates the Secretion of a Cytokine-induced Neutrophil Chemoattractant, CINC/gro, in the Rat Ovarian Cell Culture

Yasui T, Matsuzaki T, Ogata R, Kiyokawa M, Ushigoe K, Uemura H, Kuwahara A, Ikawa H, Maegawa M, Furumoto H, Aono T, Irahara M. The herbal medicine Unkei‐to stimulates the secretion of a cytokine‐induced neutrophil chemoattractant, CINC/gro, in the rat ovarian cell culture. AJRI 2003; 49:–© Blackwell Munksgaard, 2003 PROBLEM AND METHOD OF STUDY: We investigated the ovulation‐inducing effects of Unkei‐to, a Japanese herbal medicine, in relation to the production of sex steroid hormones (17β‐estradiol and progesterone), cytokine‐induced neutrophil chemoattractant (CINC/gro), interleukin‐1β (IL‐1β) and tumor necrosis factor α (TNF‐α) in the rat ovarian cell culture. RESULTS: Unkei‐to at a concentration of 100 μg/mL significantly stimulated the secretions of 17β‐estradiol and progesterone (P