General activity in baboons measured with a computerized, lightweight piezoelectric motion sensor: Effects of drugs
A small, 1-oz activity-monitoring device is described for measuring motor activity continuously for periods of up to 42 days. The monitor employs a piezoelectric sensor that detects extremely small accelerations induced by movements. The monitor can be placed on collars or harnesses (e.g., for rabbi...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1992-07, Vol.42 (3), p.497-507 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Hienz, Robert D. Turkkan, Jaylan S. Spear, Debra J. Sannerud, Christine A. Kaminski, Barbara J. Allens, Richard P. |
| description | A small, 1-oz activity-monitoring device is described for measuring motor activity continuously for periods of up to 42 days. The monitor employs a piezoelectric sensor that detects extremely small accelerations induced by movements. The monitor can be placed on collars or harnesses (e.g., for rabbits, cats, dogs, nonhuman primates, etc.). The use of the monitor is described within numerous laboratories studying the behavioral pharmacology of drugs in individually caged laboratory baboons. Patterns of daily activity were reliably recorded over periods of several months, and reflected the normal activity patterns of animals. The activity monitor recorded reliable drug-induced changes in general activity that paralleled the known effects of the same drugs on learned behaviors. Low doses of the stimulants cocaine and
d-amphetamine both increaed general activity. Marked reductions in general activity were observed following both the administration of Δ-9-tetrahydrocannabinol and an antihypertensive drug combination of diuretic and verapamil. |
| doi_str_mv | 10.1016/0091-3057(92)90145-6 |
| format | Article |
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d-amphetamine both increaed general activity. Marked reductions in general activity were observed following both the administration of Δ-9-tetrahydrocannabinol and an antihypertensive drug combination of diuretic and verapamil.</description><subject>Animals</subject><subject>Baboon</subject><subject>Biological and medical sciences</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>d-amphetamine</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Dronabinol - pharmacology</subject><subject>Drugs</subject><subject>Hydrochlorothiazide</subject><subject>Hydrochlorothiazide - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor activity</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>Nonhuman primates</subject><subject>Papio</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology, Experimental - instrumentation</subject><subject>Psychology. Psychoanalysis. 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Psychiatry</topic><topic>Psychopharmacology</topic><topic>Verapamil</topic><topic>Verapamil - pharmacology</topic><topic>Δ-9 THC</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hienz, Robert D.</creatorcontrib><creatorcontrib>Turkkan, Jaylan S.</creatorcontrib><creatorcontrib>Spear, Debra J.</creatorcontrib><creatorcontrib>Sannerud, Christine A.</creatorcontrib><creatorcontrib>Kaminski, Barbara J.</creatorcontrib><creatorcontrib>Allens, Richard P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hienz, Robert D.</au><au>Turkkan, Jaylan S.</au><au>Spear, Debra J.</au><au>Sannerud, Christine A.</au><au>Kaminski, Barbara J.</au><au>Allens, Richard P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>General activity in baboons measured with a computerized, lightweight piezoelectric motion sensor: Effects of drugs</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>42</volume><issue>3</issue><spage>497</spage><epage>507</epage><pages>497-507</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>A small, 1-oz activity-monitoring device is described for measuring motor activity continuously for periods of up to 42 days. 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| subjects | Animals Baboon Biological and medical sciences Cocaine Cocaine - pharmacology d-amphetamine Dextroamphetamine - pharmacology Dronabinol - pharmacology Drugs Hydrochlorothiazide Hydrochlorothiazide - pharmacology Male Medical sciences Motor activity Motor Activity - drug effects Neuropharmacology Nonhuman primates Papio Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology, Experimental - instrumentation Psychology. Psychoanalysis. Psychiatry Psychopharmacology Verapamil Verapamil - pharmacology Δ-9 THC |
| title | General activity in baboons measured with a computerized, lightweight piezoelectric motion sensor: Effects of drugs |
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