Biological Activity of Urease Formulated in Poloxamer 407 after Intraperitoneal Injection in the Rat

The advent of genetic engineering has resulted in a proliferation of protein pharmaceuticals available for a variety of therapeutic needs. However, the formulation and delivery of these proteins remain an intriguing challenge. Polymer‐based protein drug delivery systems continue to be investigated,...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1992-07, Vol.81 (7), p.626-630
Hauptverfasser:	Pec, E.A., Wout, Z.G., Johnston, T.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonia - blood Animals Biological and medical sciences Half-Life Injections, Intraperitoneal Medical sciences Pharmaceutical Vehicles Pharmacology. Drug treatments Poloxalene - administration & dosage Poloxalene - pharmacology Rats Urease - administration & dosage Urease - blood Urease - pharmacokinetics Urinary system
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