Comparisons of Outcome and Prognostic Features Among Histologic Subtypes of Renal Cell Carcinoma
Our objective was to compare cancer-specific survival and to examine associations with outcome among the histologic subtypes of renal cell carcinoma (RCC). We studied 2385 patients whose first surgery between 1970 and 2000 was a radical nephrectomy for sporadic, unilateral RCC. All RCC tumors were c...
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| Veröffentlicht in: | The American journal of surgical pathology 2003-05, Vol.27 (5), p.612-624 |
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| creator | Cheville, John C Lohse, Christine M Zincke, Horst Weaver, Amy L Blute, Michael L |
| description | Our objective was to compare cancer-specific survival and to examine associations with outcome among the histologic subtypes of renal cell carcinoma (RCC). We studied 2385 patients whose first surgery between 1970 and 2000 was a radical nephrectomy for sporadic, unilateral RCC. All RCC tumors were classified following the 1997 Union Internationale Contre le Cancer and American Joint Committee on Cancer guidelines. There were 1985 (83.2%) patients with clear cell, 270 (11.3%) with papillary, 102 (4.3%) with chromophobe, 6 (0.3%) with collecting duct, 5 (0.3%) with purely sarcomatoid RCC and no underlying histologic subtype, and 17 (0.7%) with RCC, not otherwise specified. Cancer-specific survival rates at 5 years for patients with clear cell, papillary, and chromophobe RCC were 68.9%, 87.4%, and 86.7%, respectively. Patients with clear cell RCC had a poorer prognosis compared with patients with papillary and chromophobe RCC (p |
| doi_str_mv | 10.1097/00000478-200305000-00005 |
| format | Article |
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We studied 2385 patients whose first surgery between 1970 and 2000 was a radical nephrectomy for sporadic, unilateral RCC. All RCC tumors were classified following the 1997 Union Internationale Contre le Cancer and American Joint Committee on Cancer guidelines. There were 1985 (83.2%) patients with clear cell, 270 (11.3%) with papillary, 102 (4.3%) with chromophobe, 6 (0.3%) with collecting duct, 5 (0.3%) with purely sarcomatoid RCC and no underlying histologic subtype, and 17 (0.7%) with RCC, not otherwise specified. Cancer-specific survival rates at 5 years for patients with clear cell, papillary, and chromophobe RCC were 68.9%, 87.4%, and 86.7%, respectively. Patients with clear cell RCC had a poorer prognosis compared with patients with papillary and chromophobe RCC (p <0.001). This difference in outcome was observed even after stratifying by 1997 tumor stage and nuclear grade. There was no significant difference in cancer-specific survival between patients with papillary and chromophobe RCC (p = 0.918). The 1997 TNM stage, tumor size, presence of a sarcomatoid component, and nuclear grade were significantly associated with death from clear cell, papillary, and chromophobe RCC. Histologic tumor necrosis was significantly associated with death from clear cell and chromophobe RCC, but not with death from papillary RCC. Our results demonstrate that there are significant differences in outcome and associations with outcome for the different histologic subtypes of RCC, highlighting the need for accurate subtyping.</description><identifier>ISSN: 0147-5185</identifier><identifier>EISSN: 1532-0979</identifier><identifier>DOI: 10.1097/00000478-200305000-00005</identifier><identifier>PMID: 12717246</identifier><identifier>CODEN: AJSPDX</identifier><language>eng</language><publisher>Hagerstown, MD: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adenocarcinoma, Clear Cell - mortality ; Adenocarcinoma, Clear Cell - pathology ; Adenocarcinoma, Clear Cell - surgery ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Papillary - mortality ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - surgery ; Carcinoma, Renal Cell - classification ; Carcinoma, Renal Cell - mortality ; Carcinoma, Renal Cell - secondary ; Carcinoma, Renal Cell - surgery ; Cell Nucleus - pathology ; Cytoplasm - pathology ; Eosine Yellowish-(YS) ; Female ; Humans ; Kidney Neoplasms - classification ; Kidney Neoplasms - mortality ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Sarcoma - mortality ; Sarcoma - pathology ; Sarcoma - surgery ; Staining and Labeling ; Survival Analysis ; Survival Rate ; Tumors of the urinary system</subject><ispartof>The American journal of surgical pathology, 2003-05, Vol.27 (5), p.612-624</ispartof><rights>Copyright © 2003 Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4525-f24cc8c321840bba9478448ed939008b0622ad820ed4fb63edaacae4f7dec5033</citedby><cites>FETCH-LOGICAL-c4525-f24cc8c321840bba9478448ed939008b0622ad820ed4fb63edaacae4f7dec5033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14751830$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12717246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheville, John C</creatorcontrib><creatorcontrib>Lohse, Christine M</creatorcontrib><creatorcontrib>Zincke, Horst</creatorcontrib><creatorcontrib>Weaver, Amy L</creatorcontrib><creatorcontrib>Blute, Michael L</creatorcontrib><title>Comparisons of Outcome and Prognostic Features Among Histologic Subtypes of Renal Cell Carcinoma</title><title>The American journal of surgical pathology</title><addtitle>Am J Surg Pathol</addtitle><description>Our objective was to compare cancer-specific survival and to examine associations with outcome among the histologic subtypes of renal cell carcinoma (RCC). We studied 2385 patients whose first surgery between 1970 and 2000 was a radical nephrectomy for sporadic, unilateral RCC. All RCC tumors were classified following the 1997 Union Internationale Contre le Cancer and American Joint Committee on Cancer guidelines. There were 1985 (83.2%) patients with clear cell, 270 (11.3%) with papillary, 102 (4.3%) with chromophobe, 6 (0.3%) with collecting duct, 5 (0.3%) with purely sarcomatoid RCC and no underlying histologic subtype, and 17 (0.7%) with RCC, not otherwise specified. Cancer-specific survival rates at 5 years for patients with clear cell, papillary, and chromophobe RCC were 68.9%, 87.4%, and 86.7%, respectively. Patients with clear cell RCC had a poorer prognosis compared with patients with papillary and chromophobe RCC (p <0.001). This difference in outcome was observed even after stratifying by 1997 tumor stage and nuclear grade. There was no significant difference in cancer-specific survival between patients with papillary and chromophobe RCC (p = 0.918). The 1997 TNM stage, tumor size, presence of a sarcomatoid component, and nuclear grade were significantly associated with death from clear cell, papillary, and chromophobe RCC. Histologic tumor necrosis was significantly associated with death from clear cell and chromophobe RCC, but not with death from papillary RCC. Our results demonstrate that there are significant differences in outcome and associations with outcome for the different histologic subtypes of RCC, highlighting the need for accurate subtyping.</description><subject>Adenocarcinoma, Clear Cell - mortality</subject><subject>Adenocarcinoma, Clear Cell - pathology</subject><subject>Adenocarcinoma, Clear Cell - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Papillary - mortality</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Carcinoma, Renal Cell - classification</subject><subject>Carcinoma, Renal Cell - mortality</subject><subject>Carcinoma, Renal Cell - secondary</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Cell Nucleus - pathology</subject><subject>Cytoplasm - pathology</subject><subject>Eosine Yellowish-(YS)</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Neoplasms - classification</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Sarcoma - mortality</subject><subject>Sarcoma - pathology</subject><subject>Sarcoma - surgery</subject><subject>Staining and Labeling</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Tumors of the urinary system</subject><issn>0147-5185</issn><issn>1532-0979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhi3Uqiy0fwH5Qm-B8dfGOaJVKUhIVC2c3YkzWVKSeGsnQvz7etktnPBhLI-fdzx-hzEu4ExAVZ7DdunSFhJAgcmHYpsxB2whjJJFZqoPbAFCl4UR1hyyo5T-AAhphfzEDoUsRSn1csF-r8KwwdilMCYeWn47Tz4MxHFs-I8Y1mNIU-f5JeE0R0r8Ygjjml91aQp9WOebX3M9PW_oRfyTRuz5ivocMPpuDAN-Zh9b7BN92e_H7P7y293qqri5_X69urgpvDbSFK3U3luvpLAa6hqr_DutLTWVqgBsDUspsbESqNFtvVTUIHok3ZYNeQNKHbOvu7qbGP7OlCY3dMnnVnCkMCdXKqmWVSUzaHegjyGlSK3bxG7A-OwEuK277r-77tXdl5TJ0pP9G3M9UPMm3NuZgdM9gMlj30YcfZfeOF3maSjInN5xT6GfKKbHfn6i6B4I--nBvTdd9Q9-q5Hi</recordid><startdate>200305</startdate><enddate>200305</enddate><creator>Cheville, John C</creator><creator>Lohse, Christine M</creator><creator>Zincke, Horst</creator><creator>Weaver, Amy L</creator><creator>Blute, Michael L</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200305</creationdate><title>Comparisons of Outcome and Prognostic Features Among Histologic Subtypes of Renal Cell Carcinoma</title><author>Cheville, John C ; Lohse, Christine M ; Zincke, Horst ; Weaver, Amy L ; Blute, Michael L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4525-f24cc8c321840bba9478448ed939008b0622ad820ed4fb63edaacae4f7dec5033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenocarcinoma, Clear Cell - mortality</topic><topic>Adenocarcinoma, Clear Cell - pathology</topic><topic>Adenocarcinoma, Clear Cell - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Papillary - mortality</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Carcinoma, Renal Cell - classification</topic><topic>Carcinoma, Renal Cell - mortality</topic><topic>Carcinoma, Renal Cell - secondary</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Cell Nucleus - pathology</topic><topic>Cytoplasm - pathology</topic><topic>Eosine Yellowish-(YS)</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Neoplasms - classification</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Sarcoma - mortality</topic><topic>Sarcoma - pathology</topic><topic>Sarcoma - surgery</topic><topic>Staining and Labeling</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheville, John C</creatorcontrib><creatorcontrib>Lohse, Christine M</creatorcontrib><creatorcontrib>Zincke, Horst</creatorcontrib><creatorcontrib>Weaver, Amy L</creatorcontrib><creatorcontrib>Blute, Michael L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheville, John C</au><au>Lohse, Christine M</au><au>Zincke, Horst</au><au>Weaver, Amy L</au><au>Blute, Michael L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparisons of Outcome and Prognostic Features Among Histologic Subtypes of Renal Cell Carcinoma</atitle><jtitle>The American journal of surgical pathology</jtitle><addtitle>Am J Surg Pathol</addtitle><date>2003-05</date><risdate>2003</risdate><volume>27</volume><issue>5</issue><spage>612</spage><epage>624</epage><pages>612-624</pages><issn>0147-5185</issn><eissn>1532-0979</eissn><coden>AJSPDX</coden><abstract>Our objective was to compare cancer-specific survival and to examine associations with outcome among the histologic subtypes of renal cell carcinoma (RCC). We studied 2385 patients whose first surgery between 1970 and 2000 was a radical nephrectomy for sporadic, unilateral RCC. All RCC tumors were classified following the 1997 Union Internationale Contre le Cancer and American Joint Committee on Cancer guidelines. There were 1985 (83.2%) patients with clear cell, 270 (11.3%) with papillary, 102 (4.3%) with chromophobe, 6 (0.3%) with collecting duct, 5 (0.3%) with purely sarcomatoid RCC and no underlying histologic subtype, and 17 (0.7%) with RCC, not otherwise specified. Cancer-specific survival rates at 5 years for patients with clear cell, papillary, and chromophobe RCC were 68.9%, 87.4%, and 86.7%, respectively. Patients with clear cell RCC had a poorer prognosis compared with patients with papillary and chromophobe RCC (p <0.001). This difference in outcome was observed even after stratifying by 1997 tumor stage and nuclear grade. There was no significant difference in cancer-specific survival between patients with papillary and chromophobe RCC (p = 0.918). The 1997 TNM stage, tumor size, presence of a sarcomatoid component, and nuclear grade were significantly associated with death from clear cell, papillary, and chromophobe RCC. Histologic tumor necrosis was significantly associated with death from clear cell and chromophobe RCC, but not with death from papillary RCC. Our results demonstrate that there are significant differences in outcome and associations with outcome for the different histologic subtypes of RCC, highlighting the need for accurate subtyping.</abstract><cop>Hagerstown, MD</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>12717246</pmid><doi>10.1097/00000478-200305000-00005</doi><tpages>13</tpages></addata></record> |
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| subjects | Adenocarcinoma, Clear Cell - mortality Adenocarcinoma, Clear Cell - pathology Adenocarcinoma, Clear Cell - surgery Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Papillary - mortality Carcinoma, Papillary - pathology Carcinoma, Papillary - surgery Carcinoma, Renal Cell - classification Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - secondary Carcinoma, Renal Cell - surgery Cell Nucleus - pathology Cytoplasm - pathology Eosine Yellowish-(YS) Female Humans Kidney Neoplasms - classification Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - surgery Kidneys Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Sarcoma - mortality Sarcoma - pathology Sarcoma - surgery Staining and Labeling Survival Analysis Survival Rate Tumors of the urinary system |
| title | Comparisons of Outcome and Prognostic Features Among Histologic Subtypes of Renal Cell Carcinoma |
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