Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells

To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2003-05, Vol.34 (1), p.85-90
Hauptverfasser:	Cheok, Meyling H., Yang, Wenjian, Pui, Ching-Hon, Downing, James R., Cheng, Cheng, Naeve, Clayton W., Relling, Mary V., Evans, William E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Cell cycle Chemotherapy Classical genetics, quantitative genetics, hybrids Discriminant analysis Drug dosages Drug Resistance, Neoplasm - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Gene Expression Profiling Gene Function General pharmacology Genes. Genome Genetics of eukaryotes. Biological and molecular evolution Genomics Health aspects Human Human Genetics Humans letter Leukemia Medical prognosis Medical sciences Mercaptopurine - administration & dosage Mercaptopurine - therapeutic use Metabolism Methotrexate - administration & dosage Methotrexate - therapeutic use Molecular and cellular biology Molecular genetics Oligonucleotide Array Sequence Analysis Ontology Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Physiological aspects Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Risk factors Signal transduction Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!