Origin of the stereospecificity in binding hydroxamates of α- and β-phenylalanine methylamide to thermolysin revealed by the X-ray crystallographic study

Optically active N-formyl- N-hydroxy-α-phenylalanine methylamide ( 1) and N-formyl- N-hydroxy-β-phenylalanine methylamide ( 2) were evaluated as inhibitors for thermolysin (TLN) to find that while the d-form is more potent than its enantiomer in the case of the hydroxamate of α-Phe-NHMe, in the inhi...

Ausführliche Beschreibung