Corneal Transduction to Inhibit Angiogenesis and Graft Failure

To test whether lentivirus-mediated expression of an endostatin::kringle-5 (E::K-5) fusion gene has an inhibitory effect on neovascularization and failure of corneal transplants. A lentiviral vector containing a fusion transgene comprising the human endostatin gene and the kringle-5 domain of the hu...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2003-05, Vol.44 (5), p.1837-1842
Hauptverfasser:	Murthy, Raghu C, McFarland, Trevor J, Yoken, Jon, Chen, Sandy, Barone, Chris, Burke, Dorthea, Zhang, Yi, Appukuttan, Binoy, Stout, J. Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - genetics Animals Biological and medical sciences Collagen - genetics Cornea - metabolism Corneal Neovascularization - metabolism Corneal Neovascularization - pathology Corneal Neovascularization - prevention & control Diseases of cornea, anterior segment and sclera Endostatins Fibrinolytic Agents Genetic Vectors Graft Rejection - metabolism Graft Rejection - pathology Graft Rejection - prevention & control HIV-1 - genetics Keratoplasty, Penetrating Kringles - genetics Medical sciences Ophthalmology Peptide Fragments - genetics Plasminogen - genetics Rabbits Recombinant Fusion Proteins - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Transduction, Genetic Transplantation, Homologous
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