Transcription of different exons 1 of the human neuronal nitric oxide synthase gene is dynamically regulated in a cell- and stimulus-specific manner

An extensive screening of the human neuronal nitric oxide synthase (nNOS) mRNAs in various human tissues and cell lines unraveled an extreme complexity in the transcription of this gene. Using 5' rapid amplification of cDNA ends (5'-RACE), ten different exons 1 (named 1a-1l) were identifie...

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Veröffentlicht in:	Biological chemistry 2003-03, Vol.384 (3), p.351-362
Hauptverfasser:	Boissel, Jean-Paul, Zelenka, Marek, Gödtel-Armbrust, Ute, Feuerstein, Thomas J, Förstermann, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Base Sequence Bucladesine - pharmacology Cloning, Molecular Exons Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Humans Molecular Sequence Data Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type I RNA, Messenger - genetics Transcription, Genetic - genetics Tumor Cells, Cultured Up-Regulation
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