The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript

The type 1 insulin-like growth factor receptor (IGF1R) is often overexpressed by tumors and mediates growth and apoptosis protection. We previously showed that antisense reagents complementary to the IGF1R translation start site enhance radio- and chemosensitivity and impair Atm function. However th...

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Veröffentlicht in:	The Journal of biological chemistry 2003-05, Vol.278 (18), p.15991-15997
Hauptverfasser:	Bohula, Erin A., Salisbury, Amanda J., Sohail, Muhammad, Playford, Martin P., Riedemann, Johann, Southern, Edwin M., Macaulay, Valentine M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Silencing Humans Nucleic Acid Conformation Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - genetics RNA, Messenger - chemistry RNA, Small Interfering - pharmacology Tumor Cells, Cultured
Online-Zugang:	Volltext
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