p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

Intact p73 function is shown to be an important determinant of cellular sensitivity to anticancer agents. Inhibition of p73 function by dominant-negative proteins or by mutant p53 abrogates apoptosis and cytotoxicity induced by these agents. A polymorphism encoding either arginine (72R) or proline (...

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Veröffentlicht in:	Cancer cell 2003-04, Vol.3 (4), p.387-402
Hauptverfasser:	Bergamaschi, Daniele, Gasco, Milena, Hiller, Louise, Sullivan, Alexandra, Syed, Nelofer, Trigiante, Giuseppe, Yulug, Isik, Merlano, Marco, Numico, Gianmauro, Comino, Alberto, Attard, Marlene, Reelfs, Olivier, Gusterson, Barry, Bell, Alexandra K, Heath, Victoria, Tavassoli, Mahvash, Farrell, Paul J, Smith, Paul, Lu, Xin, Crook, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis - genetics Carcinoma, Squamous Cell - genetics DNA-Binding Proteins - physiology Drug Resistance, Neoplasm - genetics Drug Therapy Female Genes, p53 - physiology Genes, Tumor Suppressor Head and Neck Neoplasms - genetics Humans Immunoblotting Immunohistochemistry Male Middle Aged Mutation Nuclear Proteins - physiology Plasmids Polymorphism, Single Nucleotide Prognosis RNA, Small Interfering - metabolism Tumor Cells, Cultured Tumor Protein p73 Tumor Suppressor Proteins
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