Reduced fitness of HIV-1 resistant to CXCR4 antagonists

HIV-1 strains with a syncytium-inducing phenotype that use CXCR4 (X4 strains) have been associated with faster disease progression and AIDS. Antiviral agents designed to block CXCR4 may prevent the emergence of X4 HIV strains but resistant strains that maintain the X4 phenotype can be raised by sequ...

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Veröffentlicht in:	Antiviral therapy 2003-02, Vol.8 (1), p.1-8
Hauptverfasser:	ARMAND-UGON, Mercedes, QUINONES-MATEU, Miguel E, GUTIERREZ, Arantxa, BARRETINA, Jordi, BLANCO, Julia, SCHOLS, Dominique, DE CLERCQ, Erik, CLOTET, Bonaventura, ESTE, José A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Base Sequence Biological and medical sciences Cell Line Drug Resistance, Viral - genetics Fundamental and applied biological sciences. Psychology Giant Cells - physiology Heterocyclic Compounds - pharmacology HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV-1 - drug effects HIV-1 - genetics HIV-1 - physiology Humans Medical sciences Microbiology Molecular Sequence Data Mutation Peptide Fragments - chemistry Peptide Fragments - genetics Pharmacology. Drug treatments Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - metabolism Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Serial Passage Virology Virus Replication
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