Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia

The role of the glutamate ‘metabotropic’ receptor was investigated in an experimental model of focal ischaemia-induced neurodegeneration. The metabotropic agonist, trans-1-amino cyclopentane-1,3-dicarboxylic acid (t-ACPD, 20 mg/kg i.p.), was administered to mice immediately after middle cerebral art...

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Veröffentlicht in:	European journal of pharmacology 1992-06, Vol.216 (2), p.335-336
Hauptverfasser:	Chiamulera, Christian, Albertini, Paola, Valerio, Enzo, Reggiani, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	activation animal models Animals Biological and medical sciences Cerebral Arteries Cerebral ischaemia Cycloleucine - analogs & derivatives Cycloleucine - pharmacology Cycloleucine - therapeutic use Disease Models, Animal Excitatory amino acids ischemia Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - metabolism Male Medical sciences Metabotropic receptors Mice Nervous system involvement in other diseases. Miscellaneous Neurology Receptors, Glutamate - drug effects Receptors, Glutamate - metabolism
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