Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia
The role of the glutamate ‘metabotropic’ receptor was investigated in an experimental model of focal ischaemia-induced neurodegeneration. The metabotropic agonist, trans-1-amino cyclopentane-1,3-dicarboxylic acid (t-ACPD, 20 mg/kg i.p.), was administered to mice immediately after middle cerebral art...
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| Veröffentlicht in: | European journal of pharmacology 1992-06, Vol.216 (2), p.335-336 |
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| container_title | European journal of pharmacology |
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| creator | Chiamulera, Christian Albertini, Paola Valerio, Enzo Reggiani, Angelo |
| description | The role of the glutamate ‘metabotropic’ receptor was investigated in an experimental model of focal ischaemia-induced neurodegeneration. The metabotropic agonist, trans-1-amino cyclopentane-1,3-dicarboxylic acid (t-ACPD, 20 mg/kg i.p.), was administered to mice immediately after middle cerebral artery occlusion (MCAO), which causes cerebral infarct. Seven days after MCAO, the mean infarct volume value of the t-ACPD-treated group (mean ± S.E. = 4.57 ± 0.73 mm
3) was significantly reduced, by 34.3%, compared to the vehicle-treated group (mean ± S.E. = 6.95 ± 0.59 mm
3, P < 0.01). This suggests that metabotropic receptor activation in the adult brain reduces excitotoxicity. |
| doi_str_mv | 10.1016/0014-2999(92)90382-E |
| format | Article |
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3) was significantly reduced, by 34.3%, compared to the vehicle-treated group (mean ± S.E. = 6.95 ± 0.59 mm
3, P < 0.01). This suggests that metabotropic receptor activation in the adult brain reduces excitotoxicity.</description><subject>activation</subject><subject>animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cerebral Arteries</subject><subject>Cerebral ischaemia</subject><subject>Cycloleucine - analogs & derivatives</subject><subject>Cycloleucine - pharmacology</subject><subject>Cycloleucine - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Excitatory amino acids</subject><subject>ischemia</subject><subject>Ischemic Attack, Transient - drug therapy</subject><subject>Ischemic Attack, Transient - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabotropic receptors</subject><subject>Mice</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Receptors, Glutamate - drug effects</subject><subject>Receptors, Glutamate - metabolism</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo67j6DRRyENFDr_nT3UkuC8syusLCXvQcMkmFjXR3xiSzsN_eamdYb3qqgver4vEeIW85u-CMj58Z430njDEfjfhkmNSi2z4jG66V6Zji4jnZPCEvyatafzLGBiOGM3LGpVFMsA2JV76lB9dSXmiOdIbmdrmVvE-eFvCwb7lUeu8qdXSBAwolN1hvgEKMuNG0oFZygKXRGce0PorZu4mm6u8dzMm9Ji-imyq8Oc1z8uPL9vv1TXd79_Xb9dVt56XRrUPXwQcho9Rq5LhA3IFUOqJZLfrR9Uo6JsO4Y8Z7F6UZPJMqOMkCN1rLc_Lh-Bdt_jpAbXZGDzBNboF8qFZJIbkY-X9BPkpMqu8R7I-gL7nWAtHuS5pdebSc2bUHu4Zs15CtEfZPD3aLZ-9O_w-7GcLfo2PwqL8_6a5iUrG4xaf6hA1SMKUHxC6PGGBoDwmKrT7B4iEkbKfZkNO_ffwGMAukKw</recordid><startdate>19920605</startdate><enddate>19920605</enddate><creator>Chiamulera, Christian</creator><creator>Albertini, Paola</creator><creator>Valerio, Enzo</creator><creator>Reggiani, Angelo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19920605</creationdate><title>Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia</title><author>Chiamulera, Christian ; Albertini, Paola ; Valerio, Enzo ; Reggiani, Angelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-712dcd23f38761d23efbe378f7028246a473a03d6b09ccaf395c037da30d19883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>activation</topic><topic>animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cerebral Arteries</topic><topic>Cerebral ischaemia</topic><topic>Cycloleucine - analogs & derivatives</topic><topic>Cycloleucine - pharmacology</topic><topic>Cycloleucine - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Excitatory amino acids</topic><topic>ischemia</topic><topic>Ischemic Attack, Transient - drug therapy</topic><topic>Ischemic Attack, Transient - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabotropic receptors</topic><topic>Mice</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Receptors, Glutamate - drug effects</topic><topic>Receptors, Glutamate - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiamulera, Christian</creatorcontrib><creatorcontrib>Albertini, Paola</creatorcontrib><creatorcontrib>Valerio, Enzo</creatorcontrib><creatorcontrib>Reggiani, Angelo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiamulera, Christian</au><au>Albertini, Paola</au><au>Valerio, Enzo</au><au>Reggiani, Angelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1992-06-05</date><risdate>1992</risdate><volume>216</volume><issue>2</issue><spage>335</spage><epage>336</epage><pages>335-336</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The role of the glutamate ‘metabotropic’ receptor was investigated in an experimental model of focal ischaemia-induced neurodegeneration. The metabotropic agonist, trans-1-amino cyclopentane-1,3-dicarboxylic acid (t-ACPD, 20 mg/kg i.p.), was administered to mice immediately after middle cerebral artery occlusion (MCAO), which causes cerebral infarct. Seven days after MCAO, the mean infarct volume value of the t-ACPD-treated group (mean ± S.E. = 4.57 ± 0.73 mm
3) was significantly reduced, by 34.3%, compared to the vehicle-treated group (mean ± S.E. = 6.95 ± 0.59 mm
3, P < 0.01). This suggests that metabotropic receptor activation in the adult brain reduces excitotoxicity.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1397020</pmid><doi>10.1016/0014-2999(92)90382-E</doi><tpages>2</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1992-06, Vol.216 (2), p.335-336 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | activation animal models Animals Biological and medical sciences Cerebral Arteries Cerebral ischaemia Cycloleucine - analogs & derivatives Cycloleucine - pharmacology Cycloleucine - therapeutic use Disease Models, Animal Excitatory amino acids ischemia Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - metabolism Male Medical sciences Metabotropic receptors Mice Nervous system involvement in other diseases. Miscellaneous Neurology Receptors, Glutamate - drug effects Receptors, Glutamate - metabolism |
| title | Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia |
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