Combination reperfusion therapy with eptifibatide and reduced-dose tenecteplase for ST-elevation myocardial infarction: results of the integrilin and tenecteplase in acute myocardial infarction (INTEGRITI) Phase II Angiographic Trial

Combination reperfusion therapy with eptifibatide and reduced-dose tenecteplase for ST-elevation myocardial infarction: results of the integrilin and tenecteplase in acute myocardial infarction (INTEGRITI) Phase II Angiographic Trial

The goal of this study was to evaluate combinations of eptifibatide with reduced-dose tenecteplase (TNK) in ST-elevation myocardial infarction (STEMI). Glycoprotein IIb/IIIa inhibitors enhance thrombolysis. The role of combination therapy in clinical practice remains to be established. Patients (n =...

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Veröffentlicht in:Journal of the American College of Cardiology 2003-04, Vol.41 (8), p.1251-1260
Hauptverfasser: Giugliano, Robert P, Roe, Matthew T, Harrington, Robert A, Gibson, C Michael, Zeymer, Uwe, Van de Werf, Frans, Baran, Kenneth W, Hobbach, Hans Peter, Woodlief, Lynn H, Hannan, Karen L, Greenberg, Sally, Miller, Joanne, Kitt, Michael M, Strony, John, McCabe, Carolyn H, Braunwald, Eugene, Califf, Robert M
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Blood Flow Velocity - drug effects
Coronary Angiography
Coronary Circulation - drug effects
Drug Administration Schedule
Drug Therapy, Combination
Eptifibatide
Female
Fibrinolytic Agents - therapeutic use
Heart Conduction System - physiopathology
Humans
Injections, Intravenous
Male
Middle Aged
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Peptides - administration & dosage
Peptides - therapeutic use
Platelet Aggregation Inhibitors - therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex - drug effects
Platelet Glycoprotein GPIIb-IIIa Complex - metabolism
Tenecteplase
Tissue Plasminogen Activator - administration & dosage
Tissue Plasminogen Activator - therapeutic use
Treatment Outcome
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Zusammenfassung:The goal of this study was to evaluate combinations of eptifibatide with reduced-dose tenecteplase (TNK) in ST-elevation myocardial infarction (STEMI). Glycoprotein IIb/IIIa inhibitors enhance thrombolysis. The role of combination therapy in clinical practice remains to be established. Patients (n = 438) with STEMI
ISSN:0735-1097
DOI:10.1016/S0735-1097(03)00123-2