Functional Disconnection Between the Prefrontal and Parietal Cortices During Working Memory Processing in Schizophrenia: A [15O]H2O PET Study
OBJECTIVE: The prefrontal-parietal circuits have been reported to play an important role in working memory. The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia. METHOD: [15O]H2O positro...
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| Veröffentlicht in: | The American journal of psychiatry 2003-05, Vol.160 (5), p.919-923 |
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| container_title | The American journal of psychiatry |
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| creator | Kim, Jae-Jin Kwon, Jun Soo Park, Hae Jeong Youn, Tak Kang, Do Hyung Kim, Myung Sun Lee, Dong Soo Lee, Myung Chul |
| description | OBJECTIVE: The prefrontal-parietal circuits have been reported to play an important role in working memory. The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia. METHOD: [15O]H2O positron emission tomography was used to compare regional blood flow changes in 12 schizophrenic and 12 healthy comparison subjects during the n-back sequential-picture working memory task. Interregional correlation was assessed by correlating the regional activation of the lateral prefrontal area with that of other activated areas in each subject group. RESULTS: Dorsolateral prefrontal activation was observed around the right superior frontal sulcus in the healthy subjects, and ventrolateral prefrontal activation below the right inferior frontal sulcus was observed in the schizophrenic patients. Activation in the right lateral prefrontal cortex was significantly correlated with activation in the bilateral inferior parietal region in the healthy subjects but was not correlated with any regional activation in the patients. CONCLUSIONS: The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia. |
| doi_str_mv | 10.1176/appi.ajp.160.5.919 |
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The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia. METHOD: [15O]H2O positron emission tomography was used to compare regional blood flow changes in 12 schizophrenic and 12 healthy comparison subjects during the n-back sequential-picture working memory task. Interregional correlation was assessed by correlating the regional activation of the lateral prefrontal area with that of other activated areas in each subject group. RESULTS: Dorsolateral prefrontal activation was observed around the right superior frontal sulcus in the healthy subjects, and ventrolateral prefrontal activation below the right inferior frontal sulcus was observed in the schizophrenic patients. Activation in the right lateral prefrontal cortex was significantly correlated with activation in the bilateral inferior parietal region in the healthy subjects but was not correlated with any regional activation in the patients. CONCLUSIONS: The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.160.5.919</identifier><identifier>PMID: 12727696</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Female ; Functional Laterality - physiology ; Humans ; Male ; Medical sciences ; Memory - physiology ; Neural Pathways - diagnostic imaging ; Neural Pathways - physiopathology ; Neuropsychological Tests ; Oxygen Radioisotopes ; Parietal Lobe - blood supply ; Parietal Lobe - diagnostic imaging ; Parietal Lobe - physiopathology ; Prefrontal Cortex - blood supply ; Prefrontal Cortex - diagnostic imaging ; Prefrontal Cortex - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - physiology ; Psychopathology. Psychiatry ; Psychoses ; Regional Blood Flow ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - diagnostic imaging ; Schizophrenia - physiopathology ; Tomography, Emission-Computed ; Water</subject><ispartof>The American journal of psychiatry, 2003-05, Vol.160 (5), p.919-923</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.160.5.919$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.160.5.919$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,778,782,21609,21610,21611,27907,27908,77545,77550</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14756354$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12727696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jae-Jin</creatorcontrib><creatorcontrib>Kwon, Jun Soo</creatorcontrib><creatorcontrib>Park, Hae Jeong</creatorcontrib><creatorcontrib>Youn, Tak</creatorcontrib><creatorcontrib>Kang, Do Hyung</creatorcontrib><creatorcontrib>Kim, Myung Sun</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Lee, Myung Chul</creatorcontrib><title>Functional Disconnection Between the Prefrontal and Parietal Cortices During Working Memory Processing in Schizophrenia: A [15O]H2O PET Study</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The prefrontal-parietal circuits have been reported to play an important role in working memory. The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia. METHOD: [15O]H2O positron emission tomography was used to compare regional blood flow changes in 12 schizophrenic and 12 healthy comparison subjects during the n-back sequential-picture working memory task. Interregional correlation was assessed by correlating the regional activation of the lateral prefrontal area with that of other activated areas in each subject group. RESULTS: Dorsolateral prefrontal activation was observed around the right superior frontal sulcus in the healthy subjects, and ventrolateral prefrontal activation below the right inferior frontal sulcus was observed in the schizophrenic patients. Activation in the right lateral prefrontal cortex was significantly correlated with activation in the bilateral inferior parietal region in the healthy subjects but was not correlated with any regional activation in the patients. CONCLUSIONS: The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - physiology</subject><subject>Neural Pathways - diagnostic imaging</subject><subject>Neural Pathways - physiopathology</subject><subject>Neuropsychological Tests</subject><subject>Oxygen Radioisotopes</subject><subject>Parietal Lobe - blood supply</subject><subject>Parietal Lobe - diagnostic imaging</subject><subject>Parietal Lobe - physiopathology</subject><subject>Prefrontal Cortex - blood supply</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Regional Blood Flow</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - physiopathology</subject><subject>Tomography, Emission-Computed</subject><subject>Water</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc9uEzEQhy0EoqHwAhyQL3Dbrf_EdsytpC1FKkqkFoGEkOX1zhKHxF7sXaHwDrwz3jaI0-g3_mYkz4fQS0pqSpU8s33va7vtaypJLWpN9SM0o4KLSjG2eIxmhBBWacG_nKBnOW9LJFyxp-iEMsWU1HKG_lyNwQ0-BrvDFz67GALcZ_wOhl8AAQ8bwOsEXYphKJANLV7b5GEKy5gG7yDjizH58B1_junHVD_CPqZDGYvlMU8dH_Ct2_jfsd8kCN6-xef4KxWrb9dshdeXd_h2GNvDc_Sks7sML471FH26urxbXlc3q_cfluc3lWVEDxW0jlJtuZItda2Waq7kgjdCNFp2orG6sw1ZSMI5ONo5QgmhbK6F0AJa3Wp-it487O1T_DlCHsy-_B12OxsgjtkozjgRShTw1REcmz20pk9-b9PB_DtgAV4fAZud3XXJBufzf26uhORiXrizB26SZrZxTOXi2VBiJpXmvltUmqLSCFNU8r8og5Fu</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Kim, Jae-Jin</creator><creator>Kwon, Jun Soo</creator><creator>Park, Hae Jeong</creator><creator>Youn, Tak</creator><creator>Kang, Do Hyung</creator><creator>Kim, Myung Sun</creator><creator>Lee, Dong Soo</creator><creator>Lee, Myung Chul</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Functional Disconnection Between the Prefrontal and Parietal Cortices During Working Memory Processing in Schizophrenia: A [15O]H2O PET Study</title><author>Kim, Jae-Jin ; Kwon, Jun Soo ; Park, Hae Jeong ; Youn, Tak ; Kang, Do Hyung ; Kim, Myung Sun ; Lee, Dong Soo ; Lee, Myung Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a209t-edc119a376d1cd96747683b55b96f5ba9fab086033ec1fc010012495595ed9d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - physiology</topic><topic>Neural Pathways - diagnostic imaging</topic><topic>Neural Pathways - physiopathology</topic><topic>Neuropsychological Tests</topic><topic>Oxygen Radioisotopes</topic><topic>Parietal Lobe - blood supply</topic><topic>Parietal Lobe - diagnostic imaging</topic><topic>Parietal Lobe - physiopathology</topic><topic>Prefrontal Cortex - blood supply</topic><topic>Prefrontal Cortex - diagnostic imaging</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance - physiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Regional Blood Flow</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - physiopathology</topic><topic>Tomography, Emission-Computed</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jae-Jin</creatorcontrib><creatorcontrib>Kwon, Jun Soo</creatorcontrib><creatorcontrib>Park, Hae Jeong</creatorcontrib><creatorcontrib>Youn, Tak</creatorcontrib><creatorcontrib>Kang, Do Hyung</creatorcontrib><creatorcontrib>Kim, Myung Sun</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Lee, Myung Chul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jae-Jin</au><au>Kwon, Jun Soo</au><au>Park, Hae Jeong</au><au>Youn, Tak</au><au>Kang, Do Hyung</au><au>Kim, Myung Sun</au><au>Lee, Dong Soo</au><au>Lee, Myung Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Disconnection Between the Prefrontal and Parietal Cortices During Working Memory Processing in Schizophrenia: A [15O]H2O PET Study</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>160</volume><issue>5</issue><spage>919</spage><epage>923</epage><pages>919-923</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: The prefrontal-parietal circuits have been reported to play an important role in working memory. The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia. METHOD: [15O]H2O positron emission tomography was used to compare regional blood flow changes in 12 schizophrenic and 12 healthy comparison subjects during the n-back sequential-picture working memory task. Interregional correlation was assessed by correlating the regional activation of the lateral prefrontal area with that of other activated areas in each subject group. RESULTS: Dorsolateral prefrontal activation was observed around the right superior frontal sulcus in the healthy subjects, and ventrolateral prefrontal activation below the right inferior frontal sulcus was observed in the schizophrenic patients. Activation in the right lateral prefrontal cortex was significantly correlated with activation in the bilateral inferior parietal region in the healthy subjects but was not correlated with any regional activation in the patients. CONCLUSIONS: The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>12727696</pmid><doi>10.1176/appi.ajp.160.5.919</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Female Functional Laterality - physiology Humans Male Medical sciences Memory - physiology Neural Pathways - diagnostic imaging Neural Pathways - physiopathology Neuropsychological Tests Oxygen Radioisotopes Parietal Lobe - blood supply Parietal Lobe - diagnostic imaging Parietal Lobe - physiopathology Prefrontal Cortex - blood supply Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - physiology Psychopathology. Psychiatry Psychoses Regional Blood Flow Schizophrenia Schizophrenia - diagnosis Schizophrenia - diagnostic imaging Schizophrenia - physiopathology Tomography, Emission-Computed Water |
| title | Functional Disconnection Between the Prefrontal and Parietal Cortices During Working Memory Processing in Schizophrenia: A [15O]H2O PET Study |
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