Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper

The vegetable, Anastasia Red, Capsicum annuum L. var. angulosum Mill. (Solanaceae) was successively extracted with hexane, acetone, methanol and 70% methanol, and the extracts were further separated into a total of 21 fractions by silica gel or octadecylsilane (ODS) column chromatography. The biolog...

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Veröffentlicht in:	Phytotherapy research 2003-04, Vol.17 (4), p.348-352
Hauptverfasser:	Motohashi, Noboru, Wakabayashi, Hidetsugu, Kurihara, Teruo, Takada, Yuko, Maruyama, Shichiro, Sakagami, Hiroshi, Nakashima, Hideki, Tani, Satoru, Shirataki, Yoshiaki, Kawase, Masami, Wolfard, Kristina, Molnár, Joseph
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Schlagworte:	Animals anti-Helicobacter pylori activity anti-HIV activity Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Capsicum Capsicum annuum L. var. angulosum Mill Carcinoma, Squamous Cell - drug therapy cytotoxic activity Drug Resistance, Multiple Drug Resistance, Neoplasm extracts and fractions Fibroblasts - drug effects General pharmacology Gingiva - drug effects Helicobacter pylori - drug effects HIV - drug effects Humans Lymphoma, T-Cell - drug therapy Medical sciences Mice Microbial Sensitivity Tests Mouth Neoplasms - drug therapy multidrug resistance reversal activity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Tumor Cells, Cultured - drug effects
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creator	Motohashi, Noboru Wakabayashi, Hidetsugu Kurihara, Teruo Takada, Yuko Maruyama, Shichiro Sakagami, Hiroshi Nakashima, Hideki Tani, Satoru Shirataki, Yoshiaki Kawase, Masami Wolfard, Kristina Molnár, Joseph
description	The vegetable, Anastasia Red, Capsicum annuum L. var. angulosum Mill. (Solanaceae) was successively extracted with hexane, acetone, methanol and 70% methanol, and the extracts were further separated into a total of 21 fractions by silica gel or octadecylsilane (ODS) column chromatography. The biological activities of extracts and fractions were determined. These extracts showed relatively higher cytotoxic activity against two human oral tumor cell lines (HSC‐2, HSG) than against normal human gingival ﬁbroblasts (HGF), suggesting a tumor‐speciﬁc cytotoxic activity. The cytotoxic activity of these extracts was enhanced by fractionation on silica gel [H2, A2, M1–M3] or ODS column chromatography [70M]. Several fractions [H2, H4, H5, A1, A2, A3, A5, A6, A7, M2] reversed the multidrug resistance (MDR) phenotype with L5178 mouse lymphoma T cells, more efﬁciently than (±)‐verapamil. The extracts and fractions did not show any detectable anti‐human immunodeﬁciency virus (HIV) or anti‐Helicobacter pylori activity. Thus, this study suggests the effective and selective antitumor potential of ‘Anastasia Red’ of sweet pepper for further phytochemical and biological investigation. Copyright © 2003 John Wiley & Sons, Ltd.
doi_str_mv	10.1002/ptr.1144
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(Solanaceae) was successively extracted with hexane, acetone, methanol and 70% methanol, and the extracts were further separated into a total of 21 fractions by silica gel or octadecylsilane (ODS) column chromatography. The biological activities of extracts and fractions were determined. These extracts showed relatively higher cytotoxic activity against two human oral tumor cell lines (HSC‐2, HSG) than against normal human gingival ﬁbroblasts (HGF), suggesting a tumor‐speciﬁc cytotoxic activity. The cytotoxic activity of these extracts was enhanced by fractionation on silica gel [H2, A2, M1–M3] or ODS column chromatography [70M]. Several fractions [H2, H4, H5, A1, A2, A3, A5, A6, A7, M2] reversed the multidrug resistance (MDR) phenotype with L5178 mouse lymphoma T cells, more efﬁciently than (±)‐verapamil. The extracts and fractions did not show any detectable anti‐human immunodeﬁciency virus (HIV) or anti‐Helicobacter pylori activity. Thus, this study suggests the effective and selective antitumor potential of ‘Anastasia Red’ of sweet pepper for further phytochemical and biological investigation. Copyright © 2003 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1144</identifier><identifier>PMID: 12722138</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; anti-Helicobacter pylori activity ; anti-HIV activity ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; Biological and medical sciences ; Capsicum ; Capsicum annuum L. var. angulosum Mill ; Carcinoma, Squamous Cell - drug therapy ; cytotoxic activity ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; extracts and fractions ; Fibroblasts - drug effects ; General pharmacology ; Gingiva - drug effects ; Helicobacter pylori - drug effects ; HIV - drug effects ; Humans ; Lymphoma, T-Cell - drug therapy ; Medical sciences ; Mice ; Microbial Sensitivity Tests ; Mouth Neoplasms - drug therapy ; multidrug resistance reversal activity ; Pharmacognosy. 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Res</addtitle><description>The vegetable, Anastasia Red, Capsicum annuum L. var. angulosum Mill. (Solanaceae) was successively extracted with hexane, acetone, methanol and 70% methanol, and the extracts were further separated into a total of 21 fractions by silica gel or octadecylsilane (ODS) column chromatography. The biological activities of extracts and fractions were determined. These extracts showed relatively higher cytotoxic activity against two human oral tumor cell lines (HSC‐2, HSG) than against normal human gingival ﬁbroblasts (HGF), suggesting a tumor‐speciﬁc cytotoxic activity. The cytotoxic activity of these extracts was enhanced by fractionation on silica gel [H2, A2, M1–M3] or ODS column chromatography [70M]. Several fractions [H2, H4, H5, A1, A2, A3, A5, A6, A7, M2] reversed the multidrug resistance (MDR) phenotype with L5178 mouse lymphoma T cells, more efﬁciently than (±)‐verapamil. The extracts and fractions did not show any detectable anti‐human immunodeﬁciency virus (HIV) or anti‐Helicobacter pylori activity. Thus, this study suggests the effective and selective antitumor potential of ‘Anastasia Red’ of sweet pepper for further phytochemical and biological investigation. Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>anti-Helicobacter pylori activity</subject><subject>anti-HIV activity</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Capsicum</subject><subject>Capsicum annuum L. var. angulosum Mill</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>cytotoxic activity</subject><subject>Drug Resistance, Multiple</subject><subject>Drug Resistance, Neoplasm</subject><subject>extracts and fractions</subject><subject>Fibroblasts - drug effects</subject><subject>General pharmacology</subject><subject>Gingiva - drug effects</subject><subject>Helicobacter pylori - drug effects</subject><subject>HIV - drug effects</subject><subject>Humans</subject><subject>Lymphoma, T-Cell - drug therapy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Mouth Neoplasms - drug therapy</subject><subject>multidrug resistance reversal activity</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10V1rFDEUBuAgit1WwV8gudH2olPzuZlclqVdhdaPUtG7kGTOlOjszphktt1_3yw72KveJIHz8B54g9A7Ss4oIezTkOMZpUK8QDNKtK6oVPwlmhEtaSVo_fsAHab0hxCiGRGv0QFlijHK6xnqF9vc5_4heGzXDV6NXQ5NHO9whBRStmsP5bmBmGyHrc9hE_IW9y22eAN3kK3r4BQfn69twSlYfAPN8eluamOAPU33ABkPMAwQ36BXre0SvJ3uI_Tz8uJ28bm6-rb8sji_qjyvpajKwRtHCOXCOy7mmkjwrYBGaK2ZZqzxc-dc7WtHvWdW1tZKzbyXUmnfOn6EPu5zh9j_GyFlswrJQ9fZNfRjMoozTqRkBZ7soY99ShFaM8SwsnFrKDG7ck0p1-zKLfT9lDm6FTRPcGqzgA8TsMnbro2lvpCenFBEzfUuqNq7-9DB9tmF5vvtzbR48uVH4OG_t_GvmSuupPn1dWnINf0hFL80S_4IStyf5g</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Motohashi, Noboru</creator><creator>Wakabayashi, Hidetsugu</creator><creator>Kurihara, Teruo</creator><creator>Takada, Yuko</creator><creator>Maruyama, Shichiro</creator><creator>Sakagami, Hiroshi</creator><creator>Nakashima, Hideki</creator><creator>Tani, Satoru</creator><creator>Shirataki, Yoshiaki</creator><creator>Kawase, Masami</creator><creator>Wolfard, Kristina</creator><creator>Molnár, Joseph</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200304</creationdate><title>Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper</title><author>Motohashi, Noboru ; Wakabayashi, Hidetsugu ; Kurihara, Teruo ; Takada, Yuko ; Maruyama, Shichiro ; Sakagami, Hiroshi ; Nakashima, Hideki ; Tani, Satoru ; Shirataki, Yoshiaki ; Kawase, Masami ; Wolfard, Kristina ; Molnár, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3854-3853db00134cb346905ecf4ed49992922dc6bbb8c8b1cc2a58aa592cc5579cfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>anti-Helicobacter pylori activity</topic><topic>anti-HIV activity</topic><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Capsicum</topic><topic>Capsicum annuum L. var. angulosum Mill</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>cytotoxic activity</topic><topic>Drug Resistance, Multiple</topic><topic>Drug Resistance, Neoplasm</topic><topic>extracts and fractions</topic><topic>Fibroblasts - drug effects</topic><topic>General pharmacology</topic><topic>Gingiva - drug effects</topic><topic>Helicobacter pylori - drug effects</topic><topic>HIV - drug effects</topic><topic>Humans</topic><topic>Lymphoma, T-Cell - drug therapy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Mouth Neoplasms - drug therapy</topic><topic>multidrug resistance reversal activity</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motohashi, Noboru</creatorcontrib><creatorcontrib>Wakabayashi, Hidetsugu</creatorcontrib><creatorcontrib>Kurihara, Teruo</creatorcontrib><creatorcontrib>Takada, Yuko</creatorcontrib><creatorcontrib>Maruyama, Shichiro</creatorcontrib><creatorcontrib>Sakagami, Hiroshi</creatorcontrib><creatorcontrib>Nakashima, Hideki</creatorcontrib><creatorcontrib>Tani, Satoru</creatorcontrib><creatorcontrib>Shirataki, Yoshiaki</creatorcontrib><creatorcontrib>Kawase, Masami</creatorcontrib><creatorcontrib>Wolfard, Kristina</creatorcontrib><creatorcontrib>Molnár, Joseph</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motohashi, Noboru</au><au>Wakabayashi, Hidetsugu</au><au>Kurihara, Teruo</au><au>Takada, Yuko</au><au>Maruyama, Shichiro</au><au>Sakagami, Hiroshi</au><au>Nakashima, Hideki</au><au>Tani, Satoru</au><au>Shirataki, Yoshiaki</au><au>Kawase, Masami</au><au>Wolfard, Kristina</au><au>Molnár, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2003-04</date><risdate>2003</risdate><volume>17</volume><issue>4</issue><spage>348</spage><epage>352</epage><pages>348-352</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The vegetable, Anastasia Red, Capsicum annuum L. var. angulosum Mill. (Solanaceae) was successively extracted with hexane, acetone, methanol and 70% methanol, and the extracts were further separated into a total of 21 fractions by silica gel or octadecylsilane (ODS) column chromatography. The biological activities of extracts and fractions were determined. These extracts showed relatively higher cytotoxic activity against two human oral tumor cell lines (HSC‐2, HSG) than against normal human gingival ﬁbroblasts (HGF), suggesting a tumor‐speciﬁc cytotoxic activity. The cytotoxic activity of these extracts was enhanced by fractionation on silica gel [H2, A2, M1–M3] or ODS column chromatography [70M]. Several fractions [H2, H4, H5, A1, A2, A3, A5, A6, A7, M2] reversed the multidrug resistance (MDR) phenotype with L5178 mouse lymphoma T cells, more efﬁciently than (±)‐verapamil. The extracts and fractions did not show any detectable anti‐human immunodeﬁciency virus (HIV) or anti‐Helicobacter pylori activity. Thus, this study suggests the effective and selective antitumor potential of ‘Anastasia Red’ of sweet pepper for further phytochemical and biological investigation. Copyright © 2003 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12722138</pmid><doi>10.1002/ptr.1144</doi><tpages>5</tpages></addata></record>
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subjects	Animals anti-Helicobacter pylori activity anti-HIV activity Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Capsicum Capsicum annuum L. var. angulosum Mill Carcinoma, Squamous Cell - drug therapy cytotoxic activity Drug Resistance, Multiple Drug Resistance, Neoplasm extracts and fractions Fibroblasts - drug effects General pharmacology Gingiva - drug effects Helicobacter pylori - drug effects HIV - drug effects Humans Lymphoma, T-Cell - drug therapy Medical sciences Mice Microbial Sensitivity Tests Mouth Neoplasms - drug therapy multidrug resistance reversal activity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Tumor Cells, Cultured - drug effects
title	Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper
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