Spontaneous squamous cysts and squamous epithelial plaques in the heart of cynomolgus monkeys (Macaca fascicularis)
Squamous cysts and squamous epithelial plaques were observed in a total of seventeen cynomolgus monkeys. Eleven monkeys had squamous cysts, three of them also revealed squamous plaques and six revealed squamous plaques exclusively. At necropsy, cysts were recognized as yellow-white nodules with a sm...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2003, Vol.54 (4), p.301-303 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
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| creator | Kaspareit, J. Friderichs-Gromoll, S. Buse, E. Habermann, G. Vogel, F. |
| description | Squamous cysts and squamous epithelial plaques were observed in a total of seventeen cynomolgus monkeys. Eleven monkeys had squamous cysts, three of them also revealed squamous plaques and six revealed squamous plaques exclusively. At necropsy, cysts were recognized as yellow-white nodules with a smooth surface, that were located superficially along the interventricular septum, on the surface of the left ventricle or the apex of the heart. Microscopically, cysts were lined by a flattened epithelium and filled with keratin. Occasionally the epithelium was multi-layered or replaced by a rim of foreign body-type multinucleated giant cells. All animals with squamous cysts came from Mauritius, while those with squamous plaques came from Mauritius, China and Vietnam.
As discussed in man, squamous cysts and plaques in cynomolgus monkeys are considered to represent displaced foregut epithelium, that was sequestered in the dorsal mesocardium prior to closure of the pleuropericardial fold during early embryologic development. |
| doi_str_mv | 10.1078/0940-2993-00259 |
| format | Article |
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As discussed in man, squamous cysts and plaques in cynomolgus monkeys are considered to represent displaced foregut epithelium, that was sequestered in the dorsal mesocardium prior to closure of the pleuropericardial fold during early embryologic development.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1078/0940-2993-00259</identifier><identifier>PMID: 12710713</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>Animals ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiomyopathies - metabolism ; Cardiomyopathies - pathology ; Cardiomyopathies - veterinary ; cynomolgus monkey ; Cysts - metabolism ; Cysts - pathology ; Cysts - veterinary ; Epithelium - metabolism ; Epithelium - pathology ; Female ; Heart ; Keratins - metabolism ; Macaca fascicularis ; Male ; Medical sciences ; Monkey Diseases - metabolism ; Monkey Diseases - pathology ; primate ; Squamous cysts ; squamous epithelial plaques ; Tumors of the heart</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2003, Vol.54 (4), p.301-303</ispartof><rights>2003 Urban & Fischer Verlag</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-9a60e31c4465ef55fcc6d125b0fb71a58ec443408c92572a0a3a6680455bca53</citedby><cites>FETCH-LOGICAL-c439t-9a60e31c4465ef55fcc6d125b0fb71a58ec443408c92572a0a3a6680455bca53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0940299304701098$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14600200$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12710713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaspareit, J.</creatorcontrib><creatorcontrib>Friderichs-Gromoll, S.</creatorcontrib><creatorcontrib>Buse, E.</creatorcontrib><creatorcontrib>Habermann, G.</creatorcontrib><creatorcontrib>Vogel, F.</creatorcontrib><title>Spontaneous squamous cysts and squamous epithelial plaques in the heart of cynomolgus monkeys (Macaca fascicularis)</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>Squamous cysts and squamous epithelial plaques were observed in a total of seventeen cynomolgus monkeys. Eleven monkeys had squamous cysts, three of them also revealed squamous plaques and six revealed squamous plaques exclusively. At necropsy, cysts were recognized as yellow-white nodules with a smooth surface, that were located superficially along the interventricular septum, on the surface of the left ventricle or the apex of the heart. Microscopically, cysts were lined by a flattened epithelium and filled with keratin. Occasionally the epithelium was multi-layered or replaced by a rim of foreign body-type multinucleated giant cells. All animals with squamous cysts came from Mauritius, while those with squamous plaques came from Mauritius, China and Vietnam.
As discussed in man, squamous cysts and plaques in cynomolgus monkeys are considered to represent displaced foregut epithelium, that was sequestered in the dorsal mesocardium prior to closure of the pleuropericardial fold during early embryologic development.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathies - metabolism</subject><subject>Cardiomyopathies - pathology</subject><subject>Cardiomyopathies - veterinary</subject><subject>cynomolgus monkey</subject><subject>Cysts - metabolism</subject><subject>Cysts - pathology</subject><subject>Cysts - veterinary</subject><subject>Epithelium - metabolism</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Heart</subject><subject>Keratins - metabolism</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monkey Diseases - metabolism</subject><subject>Monkey Diseases - pathology</subject><subject>primate</subject><subject>Squamous cysts</subject><subject>squamous epithelial plaques</subject><subject>Tumors of the heart</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQQK0KVJal594qX0D0ELDjOImPaNUPpK04wN2adSbF1ImDnSDtv6_TrNhT5YOtmTejmWdCPnN2w1lV3zJVsCxXSmSM5VJ9ICte8jrjhRAnZPWePSPnMb4khCnJP5IznlepnIsViY-D70fo0U-RxtcJuvlh9nGMFPrmGMLBjs_oLDg6OHidMFLb0xSizwhhpL5NVb3vvPud6M73f3Af6fUvMOnQFqKxZnIQbPx6QU5bcBE_He41efr-7WnzM9s-_Ljf3G0zUwg1ZgpKhoKboigltlK2xpQNz-WOtbuKg6wxpUTBaqNyWeXAQEBZ1qyQcmdAijW5WtoOwc_zjrqz0aBzy7a6EnmuRDK1JrcLaIKPMWCrh2A7CHvNmZ4161mknkXqf5pTxZdD62nXYXPkD14TcHkA0uLg2gC9sfHIFeX8GSxxauEweXizGHTyhL3BxgY0o268_e8QfwFALZik</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Kaspareit, J.</creator><creator>Friderichs-Gromoll, S.</creator><creator>Buse, E.</creator><creator>Habermann, G.</creator><creator>Vogel, F.</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Spontaneous squamous cysts and squamous epithelial plaques in the heart of cynomolgus monkeys (Macaca fascicularis)</title><author>Kaspareit, J. ; Friderichs-Gromoll, S. ; Buse, E. ; Habermann, G. ; Vogel, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-9a60e31c4465ef55fcc6d125b0fb71a58ec443408c92572a0a3a6680455bca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathies - metabolism</topic><topic>Cardiomyopathies - pathology</topic><topic>Cardiomyopathies - veterinary</topic><topic>cynomolgus monkey</topic><topic>Cysts - metabolism</topic><topic>Cysts - pathology</topic><topic>Cysts - veterinary</topic><topic>Epithelium - metabolism</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Heart</topic><topic>Keratins - metabolism</topic><topic>Macaca fascicularis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monkey Diseases - metabolism</topic><topic>Monkey Diseases - pathology</topic><topic>primate</topic><topic>Squamous cysts</topic><topic>squamous epithelial plaques</topic><topic>Tumors of the heart</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaspareit, J.</creatorcontrib><creatorcontrib>Friderichs-Gromoll, S.</creatorcontrib><creatorcontrib>Buse, E.</creatorcontrib><creatorcontrib>Habermann, G.</creatorcontrib><creatorcontrib>Vogel, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaspareit, J.</au><au>Friderichs-Gromoll, S.</au><au>Buse, E.</au><au>Habermann, G.</au><au>Vogel, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous squamous cysts and squamous epithelial plaques in the heart of cynomolgus monkeys (Macaca fascicularis)</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>2003</date><risdate>2003</risdate><volume>54</volume><issue>4</issue><spage>301</spage><epage>303</epage><pages>301-303</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>Squamous cysts and squamous epithelial plaques were observed in a total of seventeen cynomolgus monkeys. Eleven monkeys had squamous cysts, three of them also revealed squamous plaques and six revealed squamous plaques exclusively. At necropsy, cysts were recognized as yellow-white nodules with a smooth surface, that were located superficially along the interventricular septum, on the surface of the left ventricle or the apex of the heart. Microscopically, cysts were lined by a flattened epithelium and filled with keratin. Occasionally the epithelium was multi-layered or replaced by a rim of foreign body-type multinucleated giant cells. All animals with squamous cysts came from Mauritius, while those with squamous plaques came from Mauritius, China and Vietnam.
As discussed in man, squamous cysts and plaques in cynomolgus monkeys are considered to represent displaced foregut epithelium, that was sequestered in the dorsal mesocardium prior to closure of the pleuropericardial fold during early embryologic development.</abstract><cop>Jena</cop><pub>Elsevier GmbH</pub><pmid>12710713</pmid><doi>10.1078/0940-2993-00259</doi><tpages>3</tpages></addata></record> |
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| language | eng |
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| subjects | Animals Biological and medical sciences Cardiology. Vascular system Cardiomyopathies - metabolism Cardiomyopathies - pathology Cardiomyopathies - veterinary cynomolgus monkey Cysts - metabolism Cysts - pathology Cysts - veterinary Epithelium - metabolism Epithelium - pathology Female Heart Keratins - metabolism Macaca fascicularis Male Medical sciences Monkey Diseases - metabolism Monkey Diseases - pathology primate Squamous cysts squamous epithelial plaques Tumors of the heart |
| title | Spontaneous squamous cysts and squamous epithelial plaques in the heart of cynomolgus monkeys (Macaca fascicularis) |
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