Antiangiogenic activity of lupeol from Bombax ceiba
In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity‐guided fractionati...
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| Veröffentlicht in: | Phytotherapy research 2003-04, Vol.17 (4), p.341-344 |
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| creator | You, Young-Jae Nam, Nguyen-Hai Kim, Yong Bae, Ki-Hwan Ahn, Byung-Zun |
| description | In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity‐guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 µg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK‐MEL‐2, A549, and B16‐F10 melanoma. Copyright © 2003 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1140 |
| format | Article |
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Bioactivity‐guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 µg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK‐MEL‐2, A549, and B16‐F10 melanoma. 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Homeopathy. Health food</topic><topic>Pharmacology. 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| subjects | Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals antiangiogenic activity Biological and medical sciences Bombax Bombax ceiba cytotoxicity Dose-Response Relationship, Drug Endothelium, Vascular - drug effects General pharmacology Humans lupeol Medical sciences Mice Neovascularization, Pathologic - metabolism Pentacyclic Triterpenes Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Bark Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Triterpenes - administration & dosage Triterpenes - pharmacology Triterpenes - therapeutic use Tumor Cells, Cultured - drug effects |
| title | Antiangiogenic activity of lupeol from Bombax ceiba |
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