Salivary free concentrations of Anti-Epileptic Drugs: an evaluation in a routine clinical setting
This study was aimed at correlating the salivary and serum free concentrations of anti-epileptic drugs (carbamazepine, phenytoin and sodium valproate) in a population of neurological patients in a routine clinical setting. Twenty-seven paired serum/saliva specimens from 22 patients: 10 for carbamaze...
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| Veröffentlicht in: | Acta neurologica Belgica 2003-03, Vol.103 (1), p.19-23 |
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| creator | AL ZA'ABI, Mohammed DELEU, Dirk BATCHELOR, Chris |
| description | This study was aimed at correlating the salivary and serum free concentrations of anti-epileptic drugs (carbamazepine, phenytoin and sodium valproate) in a population of neurological patients in a routine clinical setting.
Twenty-seven paired serum/saliva specimens from 22 patients: 10 for carbamazepine, 8 for phenytoin and 9 for sodium valproate were obtained to study these correlations. Salivary and serum free concentrations of anti-epileptic drugs, anti-epileptic drug dosing history, and associated information were collected prospectively. The salivary and serum free concentrations of the anti-epileptic drugs were simultaneously quantified using fluorescence polarization immunoassay (TDx analyzer).
For both carbamazepine and phenytoin there was a strong correlation between the salivary and serum free concentrations, 0.99 and 0.98, respectively. The mean ratio of salivary to serum free carbamazepine concentration was 1.02 +/- 0.11 and 0.82 +/- 0.15 for phenytoin. A poor correlation between salivary and serum free concentration was observed for sodium valproate (0.70) with a mean ratio of salivary to serum free concentration of 0.48 +/- 0.27.
Monitoring of free salivary concentrations of anti-epileptic drugs, particularly phenytoin and carbamazepine proved to be a realistic alternative in this routine clinical setting. |
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Twenty-seven paired serum/saliva specimens from 22 patients: 10 for carbamazepine, 8 for phenytoin and 9 for sodium valproate were obtained to study these correlations. Salivary and serum free concentrations of anti-epileptic drugs, anti-epileptic drug dosing history, and associated information were collected prospectively. The salivary and serum free concentrations of the anti-epileptic drugs were simultaneously quantified using fluorescence polarization immunoassay (TDx analyzer).
For both carbamazepine and phenytoin there was a strong correlation between the salivary and serum free concentrations, 0.99 and 0.98, respectively. The mean ratio of salivary to serum free carbamazepine concentration was 1.02 +/- 0.11 and 0.82 +/- 0.15 for phenytoin. A poor correlation between salivary and serum free concentration was observed for sodium valproate (0.70) with a mean ratio of salivary to serum free concentration of 0.48 +/- 0.27.
Monitoring of free salivary concentrations of anti-epileptic drugs, particularly phenytoin and carbamazepine proved to be a realistic alternative in this routine clinical setting.</description><identifier>ISSN: 0300-9009</identifier><identifier>EISSN: 2240-2993</identifier><identifier>PMID: 12704979</identifier><identifier>CODEN: ANUBBR</identifier><language>eng</language><publisher>Bruxelles: Acta medica belgica</publisher><subject>Adolescent ; Adult ; Aged ; Ambulatory Care Facilities - statistics & numerical data ; Anticonvulsants - blood ; Anticonvulsants - metabolism ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Drug Monitoring - methods ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Nervous System Diseases - blood ; Nervous System Diseases - drug therapy ; Nervous System Diseases - metabolism ; Neurology ; Neuropharmacology ; Pharmacology. Drug treatments ; Prospective Studies ; Saliva - metabolism</subject><ispartof>Acta neurologica Belgica, 2003-03, Vol.103 (1), p.19-23</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14600310$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12704979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AL ZA'ABI, Mohammed</creatorcontrib><creatorcontrib>DELEU, Dirk</creatorcontrib><creatorcontrib>BATCHELOR, Chris</creatorcontrib><title>Salivary free concentrations of Anti-Epileptic Drugs: an evaluation in a routine clinical setting</title><title>Acta neurologica Belgica</title><addtitle>Acta Neurol Belg</addtitle><description>This study was aimed at correlating the salivary and serum free concentrations of anti-epileptic drugs (carbamazepine, phenytoin and sodium valproate) in a population of neurological patients in a routine clinical setting.
Twenty-seven paired serum/saliva specimens from 22 patients: 10 for carbamazepine, 8 for phenytoin and 9 for sodium valproate were obtained to study these correlations. Salivary and serum free concentrations of anti-epileptic drugs, anti-epileptic drug dosing history, and associated information were collected prospectively. The salivary and serum free concentrations of the anti-epileptic drugs were simultaneously quantified using fluorescence polarization immunoassay (TDx analyzer).
For both carbamazepine and phenytoin there was a strong correlation between the salivary and serum free concentrations, 0.99 and 0.98, respectively. The mean ratio of salivary to serum free carbamazepine concentration was 1.02 +/- 0.11 and 0.82 +/- 0.15 for phenytoin. A poor correlation between salivary and serum free concentration was observed for sodium valproate (0.70) with a mean ratio of salivary to serum free concentration of 0.48 +/- 0.27.
Monitoring of free salivary concentrations of anti-epileptic drugs, particularly phenytoin and carbamazepine proved to be a realistic alternative in this routine clinical setting.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Ambulatory Care Facilities - statistics & numerical data</subject><subject>Anticonvulsants - blood</subject><subject>Anticonvulsants - metabolism</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Drug Monitoring - methods</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous System Diseases - blood</subject><subject>Nervous System Diseases - drug therapy</subject><subject>Nervous System Diseases - metabolism</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Saliva - metabolism</subject><issn>0300-9009</issn><issn>2240-2993</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LAzEQBuAgii21f0Fy0dvCJNlNGm-l1g8oeFDPS5KdLZFtdk2yBf-9i1acy8Dw8MK8Z2TOeQkF11qckzkIgEID6BlZpvQB05SSMyUvyYxxBaVWek7Mq-n80cQv2kZE6vrgMORosu9Don1L1yH7Yjv4DofsHb2P4z7dURMoHk03_jjqAzU09mP2YYrofPDOdDRhng77K3LRmi7h8rQX5P1h-7Z5KnYvj8-b9a4YuFC5ULpFcJUA22BTWadttbIoVSU5F0wyhyCZEo7JqgGFlbRWMulEq1xrFFixILe_uUPsP0dMuT745LDrTMB-TLUSnK9ktZrg9QmO9oBNPUR_mAqo_0qZwM0JmDQ90kYTnE__rpQAgoH4BijSbSk</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>AL ZA'ABI, Mohammed</creator><creator>DELEU, Dirk</creator><creator>BATCHELOR, Chris</creator><general>Acta medica belgica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Salivary free concentrations of Anti-Epileptic Drugs: an evaluation in a routine clinical setting</title><author>AL ZA'ABI, Mohammed ; DELEU, Dirk ; BATCHELOR, Chris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-79fe0c530bded5bc9b58be6756223161ce06173c165d07e56bb616c3f7cfa70b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Ambulatory Care Facilities - statistics & numerical data</topic><topic>Anticonvulsants - blood</topic><topic>Anticonvulsants - metabolism</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Drug Monitoring - methods</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous System Diseases - blood</topic><topic>Nervous System Diseases - drug therapy</topic><topic>Nervous System Diseases - metabolism</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Saliva - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AL ZA'ABI, Mohammed</creatorcontrib><creatorcontrib>DELEU, Dirk</creatorcontrib><creatorcontrib>BATCHELOR, Chris</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurologica Belgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AL ZA'ABI, Mohammed</au><au>DELEU, Dirk</au><au>BATCHELOR, Chris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary free concentrations of Anti-Epileptic Drugs: an evaluation in a routine clinical setting</atitle><jtitle>Acta neurologica Belgica</jtitle><addtitle>Acta Neurol Belg</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>103</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0300-9009</issn><eissn>2240-2993</eissn><coden>ANUBBR</coden><abstract>This study was aimed at correlating the salivary and serum free concentrations of anti-epileptic drugs (carbamazepine, phenytoin and sodium valproate) in a population of neurological patients in a routine clinical setting.
Twenty-seven paired serum/saliva specimens from 22 patients: 10 for carbamazepine, 8 for phenytoin and 9 for sodium valproate were obtained to study these correlations. Salivary and serum free concentrations of anti-epileptic drugs, anti-epileptic drug dosing history, and associated information were collected prospectively. The salivary and serum free concentrations of the anti-epileptic drugs were simultaneously quantified using fluorescence polarization immunoassay (TDx analyzer).
For both carbamazepine and phenytoin there was a strong correlation between the salivary and serum free concentrations, 0.99 and 0.98, respectively. The mean ratio of salivary to serum free carbamazepine concentration was 1.02 +/- 0.11 and 0.82 +/- 0.15 for phenytoin. A poor correlation between salivary and serum free concentration was observed for sodium valproate (0.70) with a mean ratio of salivary to serum free concentration of 0.48 +/- 0.27.
Monitoring of free salivary concentrations of anti-epileptic drugs, particularly phenytoin and carbamazepine proved to be a realistic alternative in this routine clinical setting.</abstract><cop>Bruxelles</cop><pub>Acta medica belgica</pub><pmid>12704979</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Ambulatory Care Facilities - statistics & numerical data Anticonvulsants - blood Anticonvulsants - metabolism Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Drug Monitoring - methods Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Linear Models Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Nervous System Diseases - blood Nervous System Diseases - drug therapy Nervous System Diseases - metabolism Neurology Neuropharmacology Pharmacology. Drug treatments Prospective Studies Saliva - metabolism |
| title | Salivary free concentrations of Anti-Epileptic Drugs: an evaluation in a routine clinical setting |
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