Clinical test of renal guanidinoacetic acid metabolism by oral citrulline and creatine loading
We devised a clinical test of renal metabolism based on the synthesis of guanidinoacetic acid from citrulline in the proximal convoluted tubule. Intravenous administration of a citrulline/creatine solution to rats with modified levels of renal glycine amidinotransferase activity revealed a strong co...
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| Veröffentlicht in: | Clinica chimica acta 1992-07, Vol.209 (1), p.9-17 |
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| creator | Kadono, Kimiaki Yamaguchi, Takeko Tetsutani, Tamiko Yasunaga, Kojiro |
| description | We devised a clinical test of renal metabolism based on the synthesis of guanidinoacetic acid from citrulline in the proximal convoluted tubule. Intravenous administration of a citrulline/creatine solution to rats with modified levels of renal glycine amidinotransferase activity revealed a strong correlation (
r = 0.921) between this activity and urinary guanidinoacetic acid excretion. Citrulline (1.75 g) and creatine (1.50 g) were administered orally to healthy individuals and patients with chronic glomerulonephritis. In the healthy individuals, urinary guanidinoacetic acid excretion increased 5-fold by 2 h after dosing (15.1 ± 2.2 vs. 2.8 ± 1.1 mg/h). In the glomerulonephritis patients, blood clearance of citrulline decreased as the creatinine clearance decreased and urinary guanidinoacetic acid excretion also decreased. Of 56 patients with glomerulonephritis or diabetes mellitus, one had increased urinary guanidinoacetic acid excretion associated with an excess of adrenal androgens. This test appears a useful, noninvasive and simple method for examining the metabolic activity of the renal proximal convoluted tubules. |
| doi_str_mv | 10.1016/0009-8981(92)90328-N |
| format | Article |
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r = 0.921) between this activity and urinary guanidinoacetic acid excretion. Citrulline (1.75 g) and creatine (1.50 g) were administered orally to healthy individuals and patients with chronic glomerulonephritis. In the healthy individuals, urinary guanidinoacetic acid excretion increased 5-fold by 2 h after dosing (15.1 ± 2.2 vs. 2.8 ± 1.1 mg/h). In the glomerulonephritis patients, blood clearance of citrulline decreased as the creatinine clearance decreased and urinary guanidinoacetic acid excretion also decreased. Of 56 patients with glomerulonephritis or diabetes mellitus, one had increased urinary guanidinoacetic acid excretion associated with an excess of adrenal androgens. This test appears a useful, noninvasive and simple method for examining the metabolic activity of the renal proximal convoluted tubules.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(92)90328-N</identifier><identifier>PMID: 1395042</identifier><identifier>CODEN: CCATAR</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>17-Ketosteroids - urine ; Amidinotransferases - metabolism ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Chronic Disease ; Citrulline ; Citrulline - blood ; Creatine ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - urine ; Female ; Fundamental and applied biological sciences. Psychology ; Glomerulonephritis - diagnosis ; Glomerulonephritis - urine ; Glycine - analogs & derivatives ; Glycine - metabolism ; Glycine - urine ; Glycine amidinotransferase ; Guanidinoacetic acid ; Humans ; Intermediary metabolites. Miscellaneous ; Kidney - metabolism ; Kidney Tubules, Proximal - metabolism ; Middle Aged ; Other biological molecules ; Ovariectomy ; Proximal tubule ; Rats ; Rats, Inbred WKY</subject><ispartof>Clinica chimica acta, 1992-07, Vol.209 (1), p.9-17</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-aa5d46d931d94605966936aae3d7471f53e0d92489381e2f11d3572621d5e7113</citedby><cites>FETCH-LOGICAL-c386t-aa5d46d931d94605966936aae3d7471f53e0d92489381e2f11d3572621d5e7113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(92)90328-N$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5472368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1395042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kadono, Kimiaki</creatorcontrib><creatorcontrib>Yamaguchi, Takeko</creatorcontrib><creatorcontrib>Tetsutani, Tamiko</creatorcontrib><creatorcontrib>Yasunaga, Kojiro</creatorcontrib><title>Clinical test of renal guanidinoacetic acid metabolism by oral citrulline and creatine loading</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>We devised a clinical test of renal metabolism based on the synthesis of guanidinoacetic acid from citrulline in the proximal convoluted tubule. Intravenous administration of a citrulline/creatine solution to rats with modified levels of renal glycine amidinotransferase activity revealed a strong correlation (
r = 0.921) between this activity and urinary guanidinoacetic acid excretion. Citrulline (1.75 g) and creatine (1.50 g) were administered orally to healthy individuals and patients with chronic glomerulonephritis. In the healthy individuals, urinary guanidinoacetic acid excretion increased 5-fold by 2 h after dosing (15.1 ± 2.2 vs. 2.8 ± 1.1 mg/h). In the glomerulonephritis patients, blood clearance of citrulline decreased as the creatinine clearance decreased and urinary guanidinoacetic acid excretion also decreased. Of 56 patients with glomerulonephritis or diabetes mellitus, one had increased urinary guanidinoacetic acid excretion associated with an excess of adrenal androgens. This test appears a useful, noninvasive and simple method for examining the metabolic activity of the renal proximal convoluted tubules.</description><subject>17-Ketosteroids - urine</subject><subject>Amidinotransferases - metabolism</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Citrulline</subject><subject>Citrulline - blood</subject><subject>Creatine</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - urine</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glomerulonephritis - diagnosis</subject><subject>Glomerulonephritis - urine</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - metabolism</subject><subject>Glycine - urine</subject><subject>Glycine amidinotransferase</subject><subject>Guanidinoacetic acid</subject><subject>Humans</subject><subject>Intermediary metabolites. Miscellaneous</subject><subject>Kidney - metabolism</subject><subject>Kidney Tubules, Proximal - metabolism</subject><subject>Middle Aged</subject><subject>Other biological molecules</subject><subject>Ovariectomy</subject><subject>Proximal tubule</subject><subject>Rats</subject><subject>Rats, Inbred WKY</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVp2GyS_oMGdCghPTjVl2XrEghL2gRCcmmuFbPSOKjYVirZgf330XaX7a0n8TLPO2geQj5zdsUZ198YY6ZqTcsvjfhqmBRt9fiBLHnbyEoqIz6S5QE5Jic5_y5RMc0XZMGlqZkSS_Jr1YcxOOjphHmisaMJx5JeZhiDD2MEh1NwFFzwdMAJ1rEPeaDrDY2pcC5Mae7LDqQweuoSwrQNfYTSfjkjRx30GT_t31Py_P325-quenj6cb-6eaicbPVUAdReaW8k90ZpVhutjdQAKH2jGt7VEpk3QrVGthxFx7mXdSO04L7GhnN5Si52e19T_DOXS-wQssO-hxHjnG0jhWiMFgVUO9ClmHPCzr6mMEDaWM7sVqvdOrNbZ9YI-1erfSy18_3-eT2g_1faeSzzL_s55CKzSzC6kA9YrRohdVuw6x2GxcVbwGSzCzg69CGhm6yP4f__eAe--5MT</recordid><startdate>19920731</startdate><enddate>19920731</enddate><creator>Kadono, Kimiaki</creator><creator>Yamaguchi, Takeko</creator><creator>Tetsutani, Tamiko</creator><creator>Yasunaga, Kojiro</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920731</creationdate><title>Clinical test of renal guanidinoacetic acid metabolism by oral citrulline and creatine loading</title><author>Kadono, Kimiaki ; Yamaguchi, Takeko ; Tetsutani, Tamiko ; Yasunaga, Kojiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-aa5d46d931d94605966936aae3d7471f53e0d92489381e2f11d3572621d5e7113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>17-Ketosteroids - urine</topic><topic>Amidinotransferases - metabolism</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Citrulline</topic><topic>Citrulline - blood</topic><topic>Creatine</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - urine</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glomerulonephritis - diagnosis</topic><topic>Glomerulonephritis - urine</topic><topic>Glycine - analogs & derivatives</topic><topic>Glycine - metabolism</topic><topic>Glycine - urine</topic><topic>Glycine amidinotransferase</topic><topic>Guanidinoacetic acid</topic><topic>Humans</topic><topic>Intermediary metabolites. Miscellaneous</topic><topic>Kidney - metabolism</topic><topic>Kidney Tubules, Proximal - metabolism</topic><topic>Middle Aged</topic><topic>Other biological molecules</topic><topic>Ovariectomy</topic><topic>Proximal tubule</topic><topic>Rats</topic><topic>Rats, Inbred WKY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kadono, Kimiaki</creatorcontrib><creatorcontrib>Yamaguchi, Takeko</creatorcontrib><creatorcontrib>Tetsutani, Tamiko</creatorcontrib><creatorcontrib>Yasunaga, Kojiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kadono, Kimiaki</au><au>Yamaguchi, Takeko</au><au>Tetsutani, Tamiko</au><au>Yasunaga, Kojiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical test of renal guanidinoacetic acid metabolism by oral citrulline and creatine loading</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1992-07-31</date><risdate>1992</risdate><volume>209</volume><issue>1</issue><spage>9</spage><epage>17</epage><pages>9-17</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><coden>CCATAR</coden><abstract>We devised a clinical test of renal metabolism based on the synthesis of guanidinoacetic acid from citrulline in the proximal convoluted tubule. Intravenous administration of a citrulline/creatine solution to rats with modified levels of renal glycine amidinotransferase activity revealed a strong correlation (
r = 0.921) between this activity and urinary guanidinoacetic acid excretion. Citrulline (1.75 g) and creatine (1.50 g) were administered orally to healthy individuals and patients with chronic glomerulonephritis. In the healthy individuals, urinary guanidinoacetic acid excretion increased 5-fold by 2 h after dosing (15.1 ± 2.2 vs. 2.8 ± 1.1 mg/h). In the glomerulonephritis patients, blood clearance of citrulline decreased as the creatinine clearance decreased and urinary guanidinoacetic acid excretion also decreased. Of 56 patients with glomerulonephritis or diabetes mellitus, one had increased urinary guanidinoacetic acid excretion associated with an excess of adrenal androgens. This test appears a useful, noninvasive and simple method for examining the metabolic activity of the renal proximal convoluted tubules.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>1395042</pmid><doi>10.1016/0009-8981(92)90328-N</doi><tpages>9</tpages></addata></record> |
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| subjects | 17-Ketosteroids - urine Amidinotransferases - metabolism Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chronic Disease Citrulline Citrulline - blood Creatine Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - urine Female Fundamental and applied biological sciences. Psychology Glomerulonephritis - diagnosis Glomerulonephritis - urine Glycine - analogs & derivatives Glycine - metabolism Glycine - urine Glycine amidinotransferase Guanidinoacetic acid Humans Intermediary metabolites. Miscellaneous Kidney - metabolism Kidney Tubules, Proximal - metabolism Middle Aged Other biological molecules Ovariectomy Proximal tubule Rats Rats, Inbred WKY |
| title | Clinical test of renal guanidinoacetic acid metabolism by oral citrulline and creatine loading |
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