Nonprostanoid prostacyclin mimetics. 2. 4,5-diphenyloxazole derivatives

4,5-Diphenyl-2-oxazolenonanoic acid (18b) was synthesized and found to inhibit ADP-induced aggregation of human platelets with an IC50 of 2.5 microM. Acid 18b displaced [3H]iloprost from human platelet membranes in a concentration-dependent fashion, consistent with 18b inhibiting platelet function b...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 1992-09, Vol.35 (19), p.3483-3497
Hauptverfasser:	Meanwell, Nicholas A, Rosenfeld, Michael J, Trehan, Ashok K, Wright, J. J. Kim, Brassard, Catherine L, Buchanan, John O, Federici, Marianne E, Fleming, J. Stuart, Gamberdella, Marianne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - antagonists & inhibitors Cell Membrane - drug effects Humans Oxazoles - chemical synthesis Oxazoles - chemistry Oxazoles - pharmacology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - pharmacology Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!