Pre- and postnatal development of high-affinity [ 3H]nicotine binding sites in rat brain regions: an autoradiographic study

The ontogeny of high affinity nicotinic cholinergic binding sites was studied in Long-Evans rat brain by in vitro autoradiography, using [ 3H]nicotine (10 nM) and cold (−)nicotine bitartrate to assess specificity. The first binding sites become detectable in spinal cord and caudal medulla oblongata...

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Veröffentlicht in:	Brain research. Developmental brain research 1992-08, Vol.68 (2), p.163-174
Hauptverfasser:	Naeff, B., Schlumpf, M., Lichtensteiger, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Brain - embryology Brain - growth & development Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral cortex Development Embryonic and Fetal Development - physiology Fetus Fundamental and applied biological sciences. Psychology Gestational Age Nicotine Nicotine - metabolism Nicotinic cholinergic receptor Rats Receptors, Nicotinic - metabolism Subplate layer Tritium Vertebrates: nervous system and sense organs
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