Syntheses of a Glycerophospholipid, C16-Platelet Activating Factor and a Palmitoyl Analogue of M-5, an Anti-inflammatory Glyceroglycolipid

Syntheses of a Glycerophospholipid, C16-Platelet Activating Factor and a Palmitoyl Analogue of M-5, an Anti-inflammatory Glyceroglycolipid

From a chiral C4-epoxide (-)-3, which is one of the synthons in our synthetic strategy for complex lipids, a glycerophospholipid C16-platelet activating factor (C16-PAF, 1) and a palmitoyl analogue (2) of an anti-inflammatory glyceroglycolipid M-5, which was previously isolated from the Okinawan mar...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1992/05/25, Vol.40(5), pp.1166-1169
Hauptverfasser: SHIBUYA, Hirotaka, KAWASHIMA, Keiko, NARITA, Norihiko, KITAGAWA, Isao
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
anti-inflammatory glyceroglycolipid
chiral C4-epoxide
complex lipid
glycerol derivative optically active
glycerolipid
Glycerophosphates - chemical synthesis
glycerophospholipid
Glycolipids - chemical synthesis
metal radical epoxide-ring opening
Palmitic Acids - chemical synthesis
Phospholipids - chemical synthesis
Platelet Activating Factor - chemical synthesis
platelet activating factor C16
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Zusammenfassung:From a chiral C4-epoxide (-)-3, which is one of the synthons in our synthetic strategy for complex lipids, a glycerophospholipid C16-platelet activating factor (C16-PAF, 1) and a palmitoyl analogue (2) of an anti-inflammatory glyceroglycolipid M-5, which was previously isolated from the Okinawan marine sponge Phyllospongia foliascens, have been synthesized.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.40.1166