Glutathione disulfide reduction in tumor mitochondria after t-butyl hydroperoxide treatment

Treatment of isolated mitochondria from rat hepatoma tumor cells (AS-30D) with the oxidant, t-butyl hydroperoxide (tBuOOH, 1 or 5 μmol/ml) resulted in the oxidation of glutathione (GSH to GSSG) and the formation of protein-glutathione mixed disulfides (ProSSG). The GSSG was retained inside of the he...

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Veröffentlicht in:	Chemico-biological interactions 1992-09, Vol.84 (2), p.125-132
Hauptverfasser:	Brodie, Ann E., Reed, Donald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Animals Antimycin A - analogs & derivatives Antimycin A - pharmacology Biological and medical sciences Carmustine - pharmacology General aspects (metabolism, cell proliferation, established cell line...) Glutathione Glutathione - analogs & derivatives Glutathione - metabolism Glutathione Disulfide Glutathione Reductase - metabolism Hepatoma Ketoglutaric Acids - pharmacology Liver Neoplasms, Experimental - metabolism Malates - pharmacology Medical sciences Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism NADP - pharmacology NADPH Oxidation Oxidation-Reduction Peroxides - pharmacology Rats Rats, Sprague-Dawley Succinates - pharmacology Succinic Acid t-Butyl hydroperoxide tert-Butylhydroperoxide Thiols Tumor cell Tumors
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