Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study
We assessed whether trivalent live, cold-adapted influenza virus (CAIV-T) vaccine provides added protection when co-administered with trivalent inactivated influenza virus vaccine (TVV) in patients with chronic obstructive pulmonary disease (COPD). Subjects ( N=2215) were randomly assigned to receiv...
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| Veröffentlicht in: | Vaccine 2003-05, Vol.21 (17), p.2133-2144 |
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| creator | Gorse, Geoffrey J O’Connor, Theresa Z Young, Stephen L Mendelman, Paul M Bradley, Suzanne F Nichol, Kristin L Strickland, James H Paulson, Daniel M Rice, Kathryn L Foster, Runi A Fulambarker, Ashok M Shigeoka, John W Kuschner, Ware G Goodman, Richard P Neuzil, Kathleen M Wittes, Janet Boardman, Kathy D Peduzzi, Peter N |
| description | We assessed whether trivalent live, cold-adapted influenza virus (CAIV-T) vaccine provides added protection when co-administered with trivalent inactivated influenza virus vaccine (TVV) in patients with chronic obstructive pulmonary disease (COPD). Subjects (
N=2215) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally (TC), or TVV and placebo (TP). The vaccines were well-tolerated. Efficacy of TC compared to TP was not statistically significant and was 0.16 for any influenza virus strain (95% confidence limit (CL): −0.22, 0.43), 0.26 for A (H3N2) virus (95% CL: −0.17, 0.53), and −0.05 for type B virus (95% CL: −1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study. |
| doi_str_mv | 10.1016/S0264-410X(02)00748-X |
| format | Article |
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N=2215) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally (TC), or TVV and placebo (TP). The vaccines were well-tolerated. Efficacy of TC compared to TP was not statistically significant and was 0.16 for any influenza virus strain (95% confidence limit (CL): −0.22, 0.43), 0.26 for A (H3N2) virus (95% CL: −0.17, 0.53), and −0.05 for type B virus (95% CL: −1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(02)00748-X</identifier><identifier>PMID: 12706704</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Intranasal ; Aged ; Biological and medical sciences ; Chronic obstructive pulmonary disease ; Disease Outbreaks ; Efficacy ; Fundamental and applied biological sciences. Psychology ; Human viral diseases ; Humans ; Immunization ; Infectious diseases ; Influenza ; Influenza vaccine ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza Vaccines - therapeutic use ; Influenza virus ; Influenza, Human - epidemiology ; Influenza, Human - immunology ; Injections, Intramuscular ; Medical sciences ; Microbiology ; Middle Aged ; Mortality ; Older people ; Placebos ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - immunology ; Reproducibility of Results ; Respiratory function ; United States - epidemiology ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Inactivated - administration & dosage ; Vaccines, Inactivated - immunology ; Vaccines, Inactivated - therapeutic use ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Virology</subject><ispartof>Vaccine, 2003-05, Vol.21 (17), p.2133-2144</ispartof><rights>2002</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 16, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-ca5b2498750ca13c81ab7b3b75ea23fd09bfe84e002dd9b22428118be3d921fe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X0200748X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14758632$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12706704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorse, Geoffrey J</creatorcontrib><creatorcontrib>O’Connor, Theresa Z</creatorcontrib><creatorcontrib>Young, Stephen L</creatorcontrib><creatorcontrib>Mendelman, Paul M</creatorcontrib><creatorcontrib>Bradley, Suzanne F</creatorcontrib><creatorcontrib>Nichol, Kristin L</creatorcontrib><creatorcontrib>Strickland, James H</creatorcontrib><creatorcontrib>Paulson, Daniel M</creatorcontrib><creatorcontrib>Rice, Kathryn L</creatorcontrib><creatorcontrib>Foster, Runi A</creatorcontrib><creatorcontrib>Fulambarker, Ashok M</creatorcontrib><creatorcontrib>Shigeoka, John W</creatorcontrib><creatorcontrib>Kuschner, Ware G</creatorcontrib><creatorcontrib>Goodman, Richard P</creatorcontrib><creatorcontrib>Neuzil, Kathleen M</creatorcontrib><creatorcontrib>Wittes, Janet</creatorcontrib><creatorcontrib>Boardman, Kathy D</creatorcontrib><creatorcontrib>Peduzzi, Peter N</creatorcontrib><title>Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>We assessed whether trivalent live, cold-adapted influenza virus (CAIV-T) vaccine provides added protection when co-administered with trivalent inactivated influenza virus vaccine (TVV) in patients with chronic obstructive pulmonary disease (COPD). Subjects (
N=2215) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally (TC), or TVV and placebo (TP). The vaccines were well-tolerated. Efficacy of TC compared to TP was not statistically significant and was 0.16 for any influenza virus strain (95% confidence limit (CL): −0.22, 0.43), 0.26 for A (H3N2) virus (95% CL: −0.17, 0.53), and −0.05 for type B virus (95% CL: −1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study.</description><subject>Administration, Intranasal</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Disease Outbreaks</subject><subject>Efficacy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infectious diseases</subject><subject>Influenza</subject><subject>Influenza vaccine</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza Vaccines - therapeutic use</subject><subject>Influenza virus</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - immunology</subject><subject>Injections, Intramuscular</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Older people</subject><subject>Placebos</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - immunology</subject><subject>Reproducibility of Results</subject><subject>Respiratory function</subject><subject>United States - epidemiology</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, Inactivated - administration & dosage</subject><subject>Vaccines, Inactivated - immunology</subject><subject>Vaccines, Inactivated - therapeutic use</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkkuLFDEUhYMoTtv6E5SAKCNYmldVqtzIMIwPGHDhg96FW8ktJkN1qiepKml_jT_V9AMHXDirEPKdk5ucQ8hTzt5wxqu3X5moVKE4W50y8YoxrepidY8seK1lIUpe3yeLv8gJeZTSNWOslLx5SE640KzSTC3I74uu8xbslo7RQ0-HjvZ-xtfUDr0rwMFmREchOOoD2NHPsNv70PUThl9AZx-nRGew1gdM-YBmHUYKburHRH_68YraqzgEb-nQpjFOOxOkm6lfDwHiljqfEBK-o0B_nOVrhw1G2DNpnNz2MXnQQZ_wyXFdku8fLr6dfyouv3z8fH52WVhVy7GwULZCNbUumQUubc2h1a1sdYkgZOdY03ZYK2RMONe0QihRc163KF0jeIdySV4efDdxuJkwjWbtk8W-h4DDlIyWQkgl9Z1gDkCIkskMnv4fLHNquhJaZfT5P-j1MMWQ32u4aqqqZDxHtyTlgbJxSCliZzbRr_MfGs7MrhRmXwqzS9wwYfalMKuse3Z0n9o1ulvVsQUZeHEEIFnouwjB-nTLKV3WlRSZe3_gMAcxe4wmWY_BovMR7Wjc4O8Y5Q9petYP</recordid><startdate>20030516</startdate><enddate>20030516</enddate><creator>Gorse, Geoffrey J</creator><creator>O’Connor, Theresa Z</creator><creator>Young, Stephen L</creator><creator>Mendelman, Paul M</creator><creator>Bradley, Suzanne F</creator><creator>Nichol, Kristin L</creator><creator>Strickland, James H</creator><creator>Paulson, Daniel M</creator><creator>Rice, Kathryn L</creator><creator>Foster, Runi A</creator><creator>Fulambarker, Ashok M</creator><creator>Shigeoka, John W</creator><creator>Kuschner, Ware G</creator><creator>Goodman, Richard P</creator><creator>Neuzil, Kathleen M</creator><creator>Wittes, Janet</creator><creator>Boardman, Kathy D</creator><creator>Peduzzi, Peter N</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7U2</scope><scope>7X8</scope></search><sort><creationdate>20030516</creationdate><title>Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study</title><author>Gorse, Geoffrey J ; O’Connor, Theresa Z ; Young, Stephen L ; Mendelman, Paul M ; Bradley, Suzanne F ; Nichol, Kristin L ; Strickland, James H ; Paulson, Daniel M ; Rice, Kathryn L ; Foster, Runi A ; Fulambarker, Ashok M ; Shigeoka, John W ; Kuschner, Ware G ; Goodman, Richard P ; Neuzil, Kathleen M ; Wittes, Janet ; Boardman, Kathy D ; Peduzzi, Peter N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-ca5b2498750ca13c81ab7b3b75ea23fd09bfe84e002dd9b22428118be3d921fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Intranasal</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Disease Outbreaks</topic><topic>Efficacy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infectious diseases</topic><topic>Influenza</topic><topic>Influenza vaccine</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza Vaccines - therapeutic use</topic><topic>Influenza virus</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - immunology</topic><topic>Injections, Intramuscular</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Older people</topic><topic>Placebos</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - immunology</topic><topic>Reproducibility of Results</topic><topic>Respiratory function</topic><topic>United States - epidemiology</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, Inactivated - 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N=2215) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally (TC), or TVV and placebo (TP). The vaccines were well-tolerated. Efficacy of TC compared to TP was not statistically significant and was 0.16 for any influenza virus strain (95% confidence limit (CL): −0.22, 0.43), 0.26 for A (H3N2) virus (95% CL: −0.17, 0.53), and −0.05 for type B virus (95% CL: −1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12706704</pmid><doi>10.1016/S0264-410X(02)00748-X</doi><tpages>12</tpages></addata></record> |
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| ispartof | Vaccine, 2003-05, Vol.21 (17), p.2133-2144 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Intranasal Aged Biological and medical sciences Chronic obstructive pulmonary disease Disease Outbreaks Efficacy Fundamental and applied biological sciences. Psychology Human viral diseases Humans Immunization Infectious diseases Influenza Influenza vaccine Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza Vaccines - therapeutic use Influenza virus Influenza, Human - epidemiology Influenza, Human - immunology Injections, Intramuscular Medical sciences Microbiology Middle Aged Mortality Older people Placebos Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - immunology Reproducibility of Results Respiratory function United States - epidemiology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology Vaccines, Inactivated - therapeutic use Viral diseases Viral diseases of the respiratory system and ent viral diseases Virology |
| title | Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study |
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