Taurine Renders the Cell Resistant to Ischemia-induced Injury in Cultured Neonatal Rat Cardiomyocytes

Taurine is found in very high concentration in the mammalian heart. Because chronic myocardial taurine loss produces myocardial injury, the effects of taurine supplementation on ischemia-induced necrosis and apoptosis were examined using a cardiomyocyte model of simulated ischemia. Neonatal rat hear...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2003-05, Vol.41 (5), p.726-733
Hauptverfasser:	Takahashi, Kyoko, Ohyabu, Yuko, Takahashi, Koichi, Solodushko, Viktoriya, Takatani, Tomoka, Itoh, Takashi, Schaffer, Stephen W, Azuma, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis - drug effects bcl-2-Associated X Protein Biological and medical sciences Cells, Cultured Medical sciences Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Necrosis Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Wistar Taurine - metabolism Taurine - pharmacology Tumor Suppressor Protein p53 - metabolism
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