Dynamics of herpes simplex virus capsid maturation visualized by time-lapse cryo-electron microscopy

The capsid of the herpes simplex virus initially assembles as a procapsid that matures through a massive conformational change of its 182 MDa surface shell. This transition, which stabilizes the fragile procapsid, is facilitated by the viral protease that releases the interaction between the shell a...

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Veröffentlicht in:	Nature structural & molecular biology 2003-05, Vol.10 (5), p.334-341
Hauptverfasser:	Heymann, J. Bernard, Cheng, Naiqian, Newcomb, William W., Trus, Benes L., Brown, Jay C., Steven, Alasdair C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological Microscopy Biomedical and Life Sciences Capsid - ultrastructure Cell Line Cricetinae Cryoelectron Microscopy - methods Electron microscopy Herpesvirus 1, Human - growth & development Herpesvirus 1, Human - ultrastructure Image Processing, Computer-Assisted Life Sciences Membrane Biology Protein Structure Simplexvirus - growth & development Simplexvirus - ultrastructure
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