Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety

4,5-Diphenyl-2-oxazolenonanoic acid (2) and 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid (3) were previously identified as nonprostanoid prostacyclin (PGI2) mimetics that inhibit ADP-induced aggregation of human platelets in vitro. The effects on biological activity of substitution and...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-09, Vol.35 (19), p.3498-3512
Hauptverfasser:	Meanwell, Nicholas A, Rosenfeld, Michael J, Trehan, Ashok K, Romine, Jeffrey L, Wright, J. J. Kim, Brassard, Catherine L, Buchanan, John O, Federici, Marianne E, Fleming, J. Stuart, Gamberdella, Marianne, Zavoico, George B, Seiler, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - antagonists & inhibitors Epoprostenol - chemistry Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Humans Oxazoles - chemical synthesis Oxazoles - chemistry Oxazoles - pharmacology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - pharmacology Structure-Activity Relationship
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