Alterations in Heme Oxygenase/Carbon Monoxide System in Pulmonary Arteries in Hypertension

Enhancement of the heme oxygenase/carbon monoxide (HO/CO) system has been shown to lower blood pressure (BP) in young (8 weeks), but not in adult (20 weeks) spontaneously hypertensive (SHR) rats. The reasons for this selective effect still remain puzzling. We investigated the effects of hemin on the...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2003-05, Vol.228 (5), p.557-563
Hauptverfasser:	Ndisang, Joseph Fomusi, Wang, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Carbon Monoxide - metabolism Cyclic GMP - metabolism Guanylate Cyclase Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 Hemin - metabolism Hypertension - metabolism Male Pulmonary Artery - metabolism Rats Rats, Inbred SHR Rats, Inbred WKY Receptors, Cytoplasmic and Nuclear - metabolism Soluble Guanylyl Cyclase
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