Comparative Effects of Atrial Natriuretic Peptide and E. coli Heat‐Stable Toxin on Rat Intestinal Transport
Summary Conflicting data have been published in favor of or against a secretory effect of atrial natriuretic peptide (ANP) in the intestine. The reported effects resemble that of Escherichia coli heat‐stable enterotoxin (ST). In this work the effects of ANP were studied in well established experimen...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1992-08, Vol.15 (2), p.105-111 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Guarino, Alfredo Tarallo, Luigi Canani, Roberto Berni Nocerino, Agostino Iafusco, Michele Raimondi, Francesco Rubino, Armido |
| description | Summary
Conflicting data have been published in favor of or against a secretory effect of atrial natriuretic peptide (ANP) in the intestine. The reported effects resemble that of Escherichia coli heat‐stable enterotoxin (ST). In this work the effects of ANP were studied in well established experimental systems and compared with that of ST. Both peptides induced a prompt secretion of water, Na, and Cl with no effects on K net transport in the in vivo rat perfused jejunum. The addition of ST, but not of ANP, evoked an increase of short circuit current in rat intestinal mucosa mounted in Ussing chambers. ST induced a significant increase in guanylate cyclase activity in intestinal homogenates, whereas ANP showed no effect. No binding sites for ANP were detected in basolateral or brush border membranes, nor in isolated enterocytes by a suction filtration technique. In conclusion, ANP acts as a short‐lived intestinal secretagogue in the rat. Its mechanism of action is different from that of E. coli ST and appears to be indirect, since is not mediated by specific intestinal receptors and is not evident in vitro. |
| doi_str_mv | 10.1002/j.1536-4801.1992.tb10615.x |
| format | Article |
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Conflicting data have been published in favor of or against a secretory effect of atrial natriuretic peptide (ANP) in the intestine. The reported effects resemble that of Escherichia coli heat‐stable enterotoxin (ST). In this work the effects of ANP were studied in well established experimental systems and compared with that of ST. Both peptides induced a prompt secretion of water, Na, and Cl with no effects on K net transport in the in vivo rat perfused jejunum. The addition of ST, but not of ANP, evoked an increase of short circuit current in rat intestinal mucosa mounted in Ussing chambers. ST induced a significant increase in guanylate cyclase activity in intestinal homogenates, whereas ANP showed no effect. No binding sites for ANP were detected in basolateral or brush border membranes, nor in isolated enterocytes by a suction filtration technique. In conclusion, ANP acts as a short‐lived intestinal secretagogue in the rat. Its mechanism of action is different from that of E. coli ST and appears to be indirect, since is not mediated by specific intestinal receptors and is not evident in vitro.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.1992.tb10615.x</identifier><identifier>PMID: 1357125</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Atrial Natriuretic Factor - metabolism ; Atrial Natriuretic Factor - pharmacology ; Atrial natriuretic peptide ; Bacterial Toxins - pharmacology ; Binding Sites - drug effects ; Biological and medical sciences ; Biological Transport - drug effects ; Cell physiology ; Chlorides - pharmacokinetics ; Cyclic GMP - metabolism ; Enterotoxin ; Enterotoxins - pharmacology ; Escherichia coli Proteins ; Fundamental and applied biological sciences. Psychology ; Guanylate cyclase ; Guanylate Cyclase - drug effects ; Hormonal regulation ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Intestinal transport ; Male ; Molecular and cellular biology ; Rats ; Rats, Wistar ; Sodium - pharmacokinetics ; Water-Electrolyte Balance - drug effects</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1992-08, Vol.15 (2), p.105-111</ispartof><rights>1992 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>Lippincott-Raven Publishers.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4325041$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1357125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guarino, Alfredo</creatorcontrib><creatorcontrib>Tarallo, Luigi</creatorcontrib><creatorcontrib>Canani, Roberto Berni</creatorcontrib><creatorcontrib>Nocerino, Agostino</creatorcontrib><creatorcontrib>Iafusco, Michele</creatorcontrib><creatorcontrib>Raimondi, Francesco</creatorcontrib><creatorcontrib>Rubino, Armido</creatorcontrib><title>Comparative Effects of Atrial Natriuretic Peptide and E. coli Heat‐Stable Toxin on Rat Intestinal Transport</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>Summary
Conflicting data have been published in favor of or against a secretory effect of atrial natriuretic peptide (ANP) in the intestine. The reported effects resemble that of Escherichia coli heat‐stable enterotoxin (ST). In this work the effects of ANP were studied in well established experimental systems and compared with that of ST. Both peptides induced a prompt secretion of water, Na, and Cl with no effects on K net transport in the in vivo rat perfused jejunum. The addition of ST, but not of ANP, evoked an increase of short circuit current in rat intestinal mucosa mounted in Ussing chambers. ST induced a significant increase in guanylate cyclase activity in intestinal homogenates, whereas ANP showed no effect. No binding sites for ANP were detected in basolateral or brush border membranes, nor in isolated enterocytes by a suction filtration technique. In conclusion, ANP acts as a short‐lived intestinal secretagogue in the rat. Its mechanism of action is different from that of E. coli ST and appears to be indirect, since is not mediated by specific intestinal receptors and is not evident in vitro.</description><subject>Animals</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>Atrial natriuretic peptide</subject><subject>Bacterial Toxins - pharmacology</subject><subject>Binding Sites - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biological Transport - drug effects</subject><subject>Cell physiology</subject><subject>Chlorides - pharmacokinetics</subject><subject>Cyclic GMP - metabolism</subject><subject>Enterotoxin</subject><subject>Enterotoxins - pharmacology</subject><subject>Escherichia coli Proteins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanylate cyclase</subject><subject>Guanylate Cyclase - drug effects</subject><subject>Hormonal regulation</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal transport</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium - pharmacokinetics</subject><subject>Water-Electrolyte Balance - drug effects</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc9u1DAQxiMEKkvhEZAshLgleOw4TritVgstqkoFy9lyvBPVi_MH26HbG4_AM_IkJGxUzpzG9nzfzKefk-QV0AwoZW8PGQhepHlJIYOqYlmsgRYgsuOjZPXQepysKJMyZQDF0-RZCAdKqcwFPUvOgAsJTKySdtO3g_Y62h9Itk2DJgbSN2QdvdWOXOupjh6jNeQGh2j3SHS3J9uMmN5ZcoE6_v7560vUtUOy64-2I31HPutILruIIdpumrLzugtD7-Pz5EmjXcAXSz1Pvr7f7jYX6dWnD5eb9VVqGC8gFWWpZVkz2WBZVrLKNUdalbIpUJu6ELVkeSGoLgDKHBsqGTLBp9LA3lTA-Xny5jR38P33cYqhWhsMOqc77MegJGdQUYBJ-O4kNL4PwWOjBm9b7e8VUDWzVgc1A1UzUDWzVgtrdZzML5ctY93i_p_1BHfqv176OhjtmomCseFBlnMmaD5nyE-yu95F9OGbG-_Qq1vULt6q6c-oAFmk83JaTrd0fppt68VmHd7_R2718eaa_z3zP5dQq5s</recordid><startdate>199208</startdate><enddate>199208</enddate><creator>Guarino, Alfredo</creator><creator>Tarallo, Luigi</creator><creator>Canani, Roberto Berni</creator><creator>Nocerino, Agostino</creator><creator>Iafusco, Michele</creator><creator>Raimondi, Francesco</creator><creator>Rubino, Armido</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199208</creationdate><title>Comparative Effects of Atrial Natriuretic Peptide and E. coli Heat‐Stable Toxin on Rat Intestinal Transport</title><author>Guarino, Alfredo ; Tarallo, Luigi ; Canani, Roberto Berni ; Nocerino, Agostino ; Iafusco, Michele ; Raimondi, Francesco ; Rubino, Armido</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2361-588a78b27fe889794a3e0987f6eacb65b724650a61184ef072e253072f1dc9133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Atrial Natriuretic Factor - metabolism</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>Atrial natriuretic peptide</topic><topic>Bacterial Toxins - pharmacology</topic><topic>Binding Sites - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biological Transport - drug effects</topic><topic>Cell physiology</topic><topic>Chlorides - pharmacokinetics</topic><topic>Cyclic GMP - metabolism</topic><topic>Enterotoxin</topic><topic>Enterotoxins - pharmacology</topic><topic>Escherichia coli Proteins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guanylate cyclase</topic><topic>Guanylate Cyclase - drug effects</topic><topic>Hormonal regulation</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal transport</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium - pharmacokinetics</topic><topic>Water-Electrolyte Balance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guarino, Alfredo</creatorcontrib><creatorcontrib>Tarallo, Luigi</creatorcontrib><creatorcontrib>Canani, Roberto Berni</creatorcontrib><creatorcontrib>Nocerino, Agostino</creatorcontrib><creatorcontrib>Iafusco, Michele</creatorcontrib><creatorcontrib>Raimondi, Francesco</creatorcontrib><creatorcontrib>Rubino, Armido</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guarino, Alfredo</au><au>Tarallo, Luigi</au><au>Canani, Roberto Berni</au><au>Nocerino, Agostino</au><au>Iafusco, Michele</au><au>Raimondi, Francesco</au><au>Rubino, Armido</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Effects of Atrial Natriuretic Peptide and E. coli Heat‐Stable Toxin on Rat Intestinal Transport</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1992-08</date><risdate>1992</risdate><volume>15</volume><issue>2</issue><spage>105</spage><epage>111</epage><pages>105-111</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>Summary
Conflicting data have been published in favor of or against a secretory effect of atrial natriuretic peptide (ANP) in the intestine. The reported effects resemble that of Escherichia coli heat‐stable enterotoxin (ST). In this work the effects of ANP were studied in well established experimental systems and compared with that of ST. Both peptides induced a prompt secretion of water, Na, and Cl with no effects on K net transport in the in vivo rat perfused jejunum. The addition of ST, but not of ANP, evoked an increase of short circuit current in rat intestinal mucosa mounted in Ussing chambers. ST induced a significant increase in guanylate cyclase activity in intestinal homogenates, whereas ANP showed no effect. No binding sites for ANP were detected in basolateral or brush border membranes, nor in isolated enterocytes by a suction filtration technique. In conclusion, ANP acts as a short‐lived intestinal secretagogue in the rat. Its mechanism of action is different from that of E. coli ST and appears to be indirect, since is not mediated by specific intestinal receptors and is not evident in vitro.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>1357125</pmid><doi>10.1002/j.1536-4801.1992.tb10615.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Atrial Natriuretic Factor - metabolism Atrial Natriuretic Factor - pharmacology Atrial natriuretic peptide Bacterial Toxins - pharmacology Binding Sites - drug effects Biological and medical sciences Biological Transport - drug effects Cell physiology Chlorides - pharmacokinetics Cyclic GMP - metabolism Enterotoxin Enterotoxins - pharmacology Escherichia coli Proteins Fundamental and applied biological sciences. Psychology Guanylate cyclase Guanylate Cyclase - drug effects Hormonal regulation Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal transport Male Molecular and cellular biology Rats Rats, Wistar Sodium - pharmacokinetics Water-Electrolyte Balance - drug effects |
| title | Comparative Effects of Atrial Natriuretic Peptide and E. coli Heat‐Stable Toxin on Rat Intestinal Transport |
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