Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs
The effect of chronic systemic treatment (once a day for 2–3 weeks) with different antidepressant drugs (desipramine, mianserin, fluvoxamine 15 mg/kg per day i.p. or s.c.) on the behavioral responses elicited by intra-accumbens injection of graded doses (1–10 000 ng) of apomorphine and two doses (10...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmacology 1992-06, Vol.217 (1), p.15-21 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 21 |
|---|---|
| container_issue | 1 |
| container_start_page | 15 |
| container_title | European journal of pharmacology |
| container_volume | 217 |
| creator | Durlach-Misteli, Cecile Van Res, Jan M. |
| description | The effect of chronic systemic treatment (once a day for 2–3 weeks) with different antidepressant drugs (desipramine, mianserin, fluvoxamine 15 mg/kg per day i.p. or s.c.) on the behavioral responses elicited by intra-accumbens injection of graded doses (1–10 000 ng) of apomorphine and two doses (10 and 100 ng) of melatonin was investigated in rats. Treatment with antidepressant drugs consistently facilitated apomorphine-induced hypermotility, but differentially influenced apomorphine-induced hypomotility. The drugs completely antagonized melatonin-induced behavioral changes (hypomotility and increased duration of sniffing). The data suggest that chronic treatment with antidepressant drugs results in postsynaptic dopamine receptor supersensitivity in the nucleus accumbens, a terminal area of the mesolimbic dopaminergic system. It is postulated that the development of supersensitivity may be mediated by the inhibition of melatonin-induced effects observed after acute and chronic treatment with these antidepressants. The present findings may be relevant for the mode of therapeutic action of antidepressant drugs. |
| doi_str_mv | 10.1016/0014-2999(92)90505-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73218407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>001429999290505X</els_id><sourcerecordid>16364012</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-212a3d2dda27f182bffb2aa8848264da769e13df7e92bb9b628cf6f5e7f7b4783</originalsourceid><addsrcrecordid>eNqFkUuLFTEQhYM4jNfRf6CQhQy6aE2qH-lsBBkfIwy4UZhdyKOikU7SJt3C_PvpO_c67hQKqqC-Kg7nEPKMs9ec8eENY7xrQEr5UsIryXrWN9cPyI6PQjZMcHhIdvfII_K41p-MsV5Cf0pOeSsFg3ZH8vs86xgSUp0cjTjpJaeQ6FbLD6RptROulWpr12gwVRr1DTVIQ5ynYPWC7g8as0Oa_YYuIae7KS3B4Vyw1m2krqzf6xNy4vVU8emxn5FvHz98vbhsrr58-nzx7qqxHRdLAxx068A5DcLzEYz3BrQex26EoXNaDBJ567xACcZIM8Bo_eB7FF6YToztGTk__J1L_rViXVQM1eI06YR5rUq0wMeOif-CfGiHjnHYwO4A2pJrLejVXELU5UZxpvaBqL3bau-2kqDuAlHX29nz4__VRHR_jw4JbPsXx72uVk--6GRDvcf6VgAb9jLfHjDcTPsdsKhqAyaLLhS0i3I5_FvHLW7SqDw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16364012</pqid></control><display><type>article</type><title>Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Durlach-Misteli, Cecile ; Van Res, Jan M.</creator><creatorcontrib>Durlach-Misteli, Cecile ; Van Res, Jan M.</creatorcontrib><description>The effect of chronic systemic treatment (once a day for 2–3 weeks) with different antidepressant drugs (desipramine, mianserin, fluvoxamine 15 mg/kg per day i.p. or s.c.) on the behavioral responses elicited by intra-accumbens injection of graded doses (1–10 000 ng) of apomorphine and two doses (10 and 100 ng) of melatonin was investigated in rats. Treatment with antidepressant drugs consistently facilitated apomorphine-induced hypermotility, but differentially influenced apomorphine-induced hypomotility. The drugs completely antagonized melatonin-induced behavioral changes (hypomotility and increased duration of sniffing). The data suggest that chronic treatment with antidepressant drugs results in postsynaptic dopamine receptor supersensitivity in the nucleus accumbens, a terminal area of the mesolimbic dopaminergic system. It is postulated that the development of supersensitivity may be mediated by the inhibition of melatonin-induced effects observed after acute and chronic treatment with these antidepressants. The present findings may be relevant for the mode of therapeutic action of antidepressant drugs.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(92)90505-X</identifier><identifier>PMID: 1397023</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antidepressant drugs ; Antidepressive Agents - pharmacology ; Apomorphine - pharmacology ; Behavior, Animal - drug effects ; Biological and medical sciences ; Desipramine - pharmacology ; Dopamine ; Dopamine - physiology ; Dose-Response Relationship, Drug ; Fluvoxamine - pharmacology ; Male ; Medical sciences ; Melatonin ; Melatonin - pharmacology ; Melatonin - physiology ; Mianserin - pharmacology ; Neuropharmacology ; Neurotransmitter Uptake Inhibitors - pharmacology ; Nucleus accumbens ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - physiology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Wistar ; Receptor supersensitivity ; Receptors, Dopamine - drug effects ; Receptors, Dopamine - physiology ; Sensitivity and Specificity</subject><ispartof>European journal of pharmacology, 1992-06, Vol.217 (1), p.15-21</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-212a3d2dda27f182bffb2aa8848264da769e13df7e92bb9b628cf6f5e7f7b4783</citedby><cites>FETCH-LOGICAL-c417t-212a3d2dda27f182bffb2aa8848264da769e13df7e92bb9b628cf6f5e7f7b4783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(92)90505-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5372067$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1397023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durlach-Misteli, Cecile</creatorcontrib><creatorcontrib>Van Res, Jan M.</creatorcontrib><title>Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The effect of chronic systemic treatment (once a day for 2–3 weeks) with different antidepressant drugs (desipramine, mianserin, fluvoxamine 15 mg/kg per day i.p. or s.c.) on the behavioral responses elicited by intra-accumbens injection of graded doses (1–10 000 ng) of apomorphine and two doses (10 and 100 ng) of melatonin was investigated in rats. Treatment with antidepressant drugs consistently facilitated apomorphine-induced hypermotility, but differentially influenced apomorphine-induced hypomotility. The drugs completely antagonized melatonin-induced behavioral changes (hypomotility and increased duration of sniffing). The data suggest that chronic treatment with antidepressant drugs results in postsynaptic dopamine receptor supersensitivity in the nucleus accumbens, a terminal area of the mesolimbic dopaminergic system. It is postulated that the development of supersensitivity may be mediated by the inhibition of melatonin-induced effects observed after acute and chronic treatment with these antidepressants. The present findings may be relevant for the mode of therapeutic action of antidepressant drugs.</description><subject>Animals</subject><subject>Antidepressant drugs</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Apomorphine - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Desipramine - pharmacology</subject><subject>Dopamine</subject><subject>Dopamine - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fluvoxamine - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melatonin</subject><subject>Melatonin - pharmacology</subject><subject>Melatonin - physiology</subject><subject>Mianserin - pharmacology</subject><subject>Neuropharmacology</subject><subject>Neurotransmitter Uptake Inhibitors - pharmacology</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor supersensitivity</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine - physiology</subject><subject>Sensitivity and Specificity</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFTEQhYM4jNfRf6CQhQy6aE2qH-lsBBkfIwy4UZhdyKOikU7SJt3C_PvpO_c67hQKqqC-Kg7nEPKMs9ec8eENY7xrQEr5UsIryXrWN9cPyI6PQjZMcHhIdvfII_K41p-MsV5Cf0pOeSsFg3ZH8vs86xgSUp0cjTjpJaeQ6FbLD6RptROulWpr12gwVRr1DTVIQ5ynYPWC7g8as0Oa_YYuIae7KS3B4Vyw1m2krqzf6xNy4vVU8emxn5FvHz98vbhsrr58-nzx7qqxHRdLAxx068A5DcLzEYz3BrQex26EoXNaDBJ567xACcZIM8Bo_eB7FF6YToztGTk__J1L_rViXVQM1eI06YR5rUq0wMeOif-CfGiHjnHYwO4A2pJrLejVXELU5UZxpvaBqL3bau-2kqDuAlHX29nz4__VRHR_jw4JbPsXx72uVk--6GRDvcf6VgAb9jLfHjDcTPsdsKhqAyaLLhS0i3I5_FvHLW7SqDw</recordid><startdate>19920624</startdate><enddate>19920624</enddate><creator>Durlach-Misteli, Cecile</creator><creator>Van Res, Jan M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920624</creationdate><title>Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs</title><author>Durlach-Misteli, Cecile ; Van Res, Jan M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-212a3d2dda27f182bffb2aa8848264da769e13df7e92bb9b628cf6f5e7f7b4783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Antidepressant drugs</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Apomorphine - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Desipramine - pharmacology</topic><topic>Dopamine</topic><topic>Dopamine - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fluvoxamine - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melatonin</topic><topic>Melatonin - pharmacology</topic><topic>Melatonin - physiology</topic><topic>Mianserin - pharmacology</topic><topic>Neuropharmacology</topic><topic>Neurotransmitter Uptake Inhibitors - pharmacology</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor supersensitivity</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Receptors, Dopamine - physiology</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durlach-Misteli, Cecile</creatorcontrib><creatorcontrib>Van Res, Jan M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durlach-Misteli, Cecile</au><au>Van Res, Jan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1992-06-24</date><risdate>1992</risdate><volume>217</volume><issue>1</issue><spage>15</spage><epage>21</epage><pages>15-21</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effect of chronic systemic treatment (once a day for 2–3 weeks) with different antidepressant drugs (desipramine, mianserin, fluvoxamine 15 mg/kg per day i.p. or s.c.) on the behavioral responses elicited by intra-accumbens injection of graded doses (1–10 000 ng) of apomorphine and two doses (10 and 100 ng) of melatonin was investigated in rats. Treatment with antidepressant drugs consistently facilitated apomorphine-induced hypermotility, but differentially influenced apomorphine-induced hypomotility. The drugs completely antagonized melatonin-induced behavioral changes (hypomotility and increased duration of sniffing). The data suggest that chronic treatment with antidepressant drugs results in postsynaptic dopamine receptor supersensitivity in the nucleus accumbens, a terminal area of the mesolimbic dopaminergic system. It is postulated that the development of supersensitivity may be mediated by the inhibition of melatonin-induced effects observed after acute and chronic treatment with these antidepressants. The present findings may be relevant for the mode of therapeutic action of antidepressant drugs.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1397023</pmid><doi>10.1016/0014-2999(92)90505-X</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1992-06, Vol.217 (1), p.15-21 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73218407 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antidepressant drugs Antidepressive Agents - pharmacology Apomorphine - pharmacology Behavior, Animal - drug effects Biological and medical sciences Desipramine - pharmacology Dopamine Dopamine - physiology Dose-Response Relationship, Drug Fluvoxamine - pharmacology Male Medical sciences Melatonin Melatonin - pharmacology Melatonin - physiology Mianserin - pharmacology Neuropharmacology Neurotransmitter Uptake Inhibitors - pharmacology Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Receptor supersensitivity Receptors, Dopamine - drug effects Receptors, Dopamine - physiology Sensitivity and Specificity |
| title | Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T11%3A31%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dopamine%20and%20melatonin%20in%20the%20nucleus%20accumbens%20may%20be%20implicated%20in%20the%20mode%20of%20action%20of%20antidepressant%20drugs&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Durlach-Misteli,%20Cecile&rft.date=1992-06-24&rft.volume=217&rft.issue=1&rft.spage=15&rft.epage=21&rft.pages=15-21&rft.issn=0014-2999&rft.eissn=1879-0712&rft.coden=EJPHAZ&rft_id=info:doi/10.1016/0014-2999(92)90505-X&rft_dat=%3Cproquest_cross%3E16364012%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16364012&rft_id=info:pmid/1397023&rft_els_id=001429999290505X&rfr_iscdi=true |