Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy
Background. The paper describes a randomized controlled trial of targeting cognitive behavioural therapy (CBT) during prodromal or early signs of relapse in schizophrenia. We hypothesized that CBT would result in reduced admission and relapse, reduced positive and negative symptoms, and improved soc...
Gespeichert in:
| Veröffentlicht in: | Psychological medicine 2003-04, Vol.33 (3), p.419-431 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 431 |
|---|---|
| container_issue | 3 |
| container_start_page | 419 |
| container_title | Psychological medicine |
| container_volume | 33 |
| creator | GUMLEY, A. O'GRADY, M. MCNAY, L. REILLY, J. POWER, K. NORRIE, J. |
| description | Background. The paper describes a randomized controlled trial of targeting cognitive behavioural therapy (CBT) during prodromal or early signs of relapse in schizophrenia. We hypothesized that CBT would result in reduced admission and relapse, reduced positive and negative symptoms, and improved social functioning. Method. A total of 144 participants with schizophrenia or a related disorder were randomized to receive either treatment as usual (TAU) (N=72) or CBT+TAU (N=72). Participants were prospectively followed up between entry and 12 months. Results. At 12 months, 11 (15·3%) participants in the CBT group were admitted to hospital compared to 19 (26·4%) of the TAU group (hazard ratio=0·53, P=0·10, 95% CI 0·25, 1·10). A total of 13 (18·1%) participants in CBT relapsed compared to 25 (34·7%) in TAU (hazard ratio=0·47, P |
| doi_str_mv | 10.1017/S0033291703007323 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73217841</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0033291703007323</cupid><sourcerecordid>57147875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c558t-a98ba29231eebc0dddbc0ec81a547371a2ee50c8a58face03967e2518df35a653</originalsourceid><addsrcrecordid>eNqFkVuP0zAQhSMEYsvCD-AFWUjwFvA1dniDalkuK3Hn1Zo6k42XJA52WtF95Y_jqhWVQIgX2_L55mhmTlHcZ_QJo0w__USpELxmmgpKteDiRrFgsqpLU2tzs1js5HKnnxR3UrqilAkm-e3ihHFNWVWJRfHzDGK_JX6cMW5wnH0YSRsiidjDlDALJLnOX4epizh6eJaVtO7nREJLgDBeDmGcOxJhbMLgr7EhLn_E0Pf5OUcP_Y504XL0s98gWWEHGx_WMQtzhxGm7d3iVgt9wnuH-7T48vLs8_JVefHu_PXy-UXplDJzCbVZAa-5YIgrR5umySc6w0BJLTQDjqioM6BMCw6pqCuNXDHTtEJBpcRp8XjvO8XwfY1ptoNPDvseRgzrZPMGmTaS_RdUmklt9M7x4R_gVZ5szENYTqWiQhqZIbaHXAwpRWztFP0AcWsZtbsc7V855poHB-P1asDmWHEILgOPDgAkB32b9-98OnKyklRxnrlyz_k044_fOsRvtspLU7Y6_2C_yhfL9_zNR_s28-LQLAyr6JtLPI7073Z_AVK4xSU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204503484</pqid></control><display><type>article</type><title>Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Cambridge University Press Journals Complete</source><creator>GUMLEY, A. ; O'GRADY, M. ; MCNAY, L. ; REILLY, J. ; POWER, K. ; NORRIE, J.</creator><creatorcontrib>GUMLEY, A. ; O'GRADY, M. ; MCNAY, L. ; REILLY, J. ; POWER, K. ; NORRIE, J.</creatorcontrib><description>Background. The paper describes a randomized controlled trial of targeting cognitive behavioural therapy (CBT) during prodromal or early signs of relapse in schizophrenia. We hypothesized that CBT would result in reduced admission and relapse, reduced positive and negative symptoms, and improved social functioning. Method. A total of 144 participants with schizophrenia or a related disorder were randomized to receive either treatment as usual (TAU) (N=72) or CBT+TAU (N=72). Participants were prospectively followed up between entry and 12 months. Results. At 12 months, 11 (15·3%) participants in the CBT group were admitted to hospital compared to 19 (26·4%) of the TAU group (hazard ratio=0·53, P=0·10, 95% CI 0·25, 1·10). A total of 13 (18·1%) participants in CBT relapsed compared to 25 (34·7%) in TAU (hazard ratio=0·47, P<0·05, 95% CI 0·24, 0·92). In addition, the CBT group showed significantly greater improvement in positive symptoms, negative symptoms, global psychopathology, performance of independent functions and prosocial activities. Conclusions. The study provides evidence for the feasibility and effectiveness for targeting CBT on the appearance of early signs of relapse in schizophrenia. The results are discussed in context of the study's methodological limitations.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291703007323</identifier><identifier>PMID: 12701663</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Behavior therapy. Cognitive therapy ; Biological and medical sciences ; Cognitive Behavioral Therapy ; Cognitive behaviour therapy ; Crisis Intervention ; Early ; Female ; Humans ; Interventions ; Male ; Medical sciences ; Patients ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Randomized controlled trials ; Recurrence ; Relapse ; Schizophrenia ; Schizophrenia - prevention & control ; Schizophrenia - therapy ; Schizophrenic Psychology ; Scotland ; Time Factors ; Treatment Outcome ; Treatments</subject><ispartof>Psychological medicine, 2003-04, Vol.33 (3), p.419-431</ispartof><rights>2003 Cambridge University Press</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-a98ba29231eebc0dddbc0ec81a547371a2ee50c8a58face03967e2518df35a653</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291703007323/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,12826,27903,27904,30978,30979,55606</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14640522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12701663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GUMLEY, A.</creatorcontrib><creatorcontrib>O'GRADY, M.</creatorcontrib><creatorcontrib>MCNAY, L.</creatorcontrib><creatorcontrib>REILLY, J.</creatorcontrib><creatorcontrib>POWER, K.</creatorcontrib><creatorcontrib>NORRIE, J.</creatorcontrib><title>Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Background. The paper describes a randomized controlled trial of targeting cognitive behavioural therapy (CBT) during prodromal or early signs of relapse in schizophrenia. We hypothesized that CBT would result in reduced admission and relapse, reduced positive and negative symptoms, and improved social functioning. Method. A total of 144 participants with schizophrenia or a related disorder were randomized to receive either treatment as usual (TAU) (N=72) or CBT+TAU (N=72). Participants were prospectively followed up between entry and 12 months. Results. At 12 months, 11 (15·3%) participants in the CBT group were admitted to hospital compared to 19 (26·4%) of the TAU group (hazard ratio=0·53, P=0·10, 95% CI 0·25, 1·10). A total of 13 (18·1%) participants in CBT relapsed compared to 25 (34·7%) in TAU (hazard ratio=0·47, P<0·05, 95% CI 0·24, 0·92). In addition, the CBT group showed significantly greater improvement in positive symptoms, negative symptoms, global psychopathology, performance of independent functions and prosocial activities. Conclusions. The study provides evidence for the feasibility and effectiveness for targeting CBT on the appearance of early signs of relapse in schizophrenia. The results are discussed in context of the study's methodological limitations.</description><subject>Behavior therapy. Cognitive therapy</subject><subject>Biological and medical sciences</subject><subject>Cognitive Behavioral Therapy</subject><subject>Cognitive behaviour therapy</subject><subject>Crisis Intervention</subject><subject>Early</subject><subject>Female</subject><subject>Humans</subject><subject>Interventions</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Patients</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Randomized controlled trials</subject><subject>Recurrence</subject><subject>Relapse</subject><subject>Schizophrenia</subject><subject>Schizophrenia - prevention & control</subject><subject>Schizophrenia - therapy</subject><subject>Schizophrenic Psychology</subject><subject>Scotland</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Treatments</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkVuP0zAQhSMEYsvCD-AFWUjwFvA1dniDalkuK3Hn1Zo6k42XJA52WtF95Y_jqhWVQIgX2_L55mhmTlHcZ_QJo0w__USpELxmmgpKteDiRrFgsqpLU2tzs1js5HKnnxR3UrqilAkm-e3ihHFNWVWJRfHzDGK_JX6cMW5wnH0YSRsiidjDlDALJLnOX4epizh6eJaVtO7nREJLgDBeDmGcOxJhbMLgr7EhLn_E0Pf5OUcP_Y504XL0s98gWWEHGx_WMQtzhxGm7d3iVgt9wnuH-7T48vLs8_JVefHu_PXy-UXplDJzCbVZAa-5YIgrR5umySc6w0BJLTQDjqioM6BMCw6pqCuNXDHTtEJBpcRp8XjvO8XwfY1ptoNPDvseRgzrZPMGmTaS_RdUmklt9M7x4R_gVZ5szENYTqWiQhqZIbaHXAwpRWztFP0AcWsZtbsc7V855poHB-P1asDmWHEILgOPDgAkB32b9-98OnKyklRxnrlyz_k044_fOsRvtspLU7Y6_2C_yhfL9_zNR_s28-LQLAyr6JtLPI7073Z_AVK4xSU</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>GUMLEY, A.</creator><creator>O'GRADY, M.</creator><creator>MCNAY, L.</creator><creator>REILLY, J.</creator><creator>POWER, K.</creator><creator>NORRIE, J.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy</title><author>GUMLEY, A. ; O'GRADY, M. ; MCNAY, L. ; REILLY, J. ; POWER, K. ; NORRIE, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-a98ba29231eebc0dddbc0ec81a547371a2ee50c8a58face03967e2518df35a653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Behavior therapy. Cognitive therapy</topic><topic>Biological and medical sciences</topic><topic>Cognitive Behavioral Therapy</topic><topic>Cognitive behaviour therapy</topic><topic>Crisis Intervention</topic><topic>Early</topic><topic>Female</topic><topic>Humans</topic><topic>Interventions</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Patients</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Randomized controlled trials</topic><topic>Recurrence</topic><topic>Relapse</topic><topic>Schizophrenia</topic><topic>Schizophrenia - prevention & control</topic><topic>Schizophrenia - therapy</topic><topic>Schizophrenic Psychology</topic><topic>Scotland</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GUMLEY, A.</creatorcontrib><creatorcontrib>O'GRADY, M.</creatorcontrib><creatorcontrib>MCNAY, L.</creatorcontrib><creatorcontrib>REILLY, J.</creatorcontrib><creatorcontrib>POWER, K.</creatorcontrib><creatorcontrib>NORRIE, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychological medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GUMLEY, A.</au><au>O'GRADY, M.</au><au>MCNAY, L.</au><au>REILLY, J.</au><au>POWER, K.</au><au>NORRIE, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>33</volume><issue>3</issue><spage>419</spage><epage>431</epage><pages>419-431</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Background. The paper describes a randomized controlled trial of targeting cognitive behavioural therapy (CBT) during prodromal or early signs of relapse in schizophrenia. We hypothesized that CBT would result in reduced admission and relapse, reduced positive and negative symptoms, and improved social functioning. Method. A total of 144 participants with schizophrenia or a related disorder were randomized to receive either treatment as usual (TAU) (N=72) or CBT+TAU (N=72). Participants were prospectively followed up between entry and 12 months. Results. At 12 months, 11 (15·3%) participants in the CBT group were admitted to hospital compared to 19 (26·4%) of the TAU group (hazard ratio=0·53, P=0·10, 95% CI 0·25, 1·10). A total of 13 (18·1%) participants in CBT relapsed compared to 25 (34·7%) in TAU (hazard ratio=0·47, P<0·05, 95% CI 0·24, 0·92). In addition, the CBT group showed significantly greater improvement in positive symptoms, negative symptoms, global psychopathology, performance of independent functions and prosocial activities. Conclusions. The study provides evidence for the feasibility and effectiveness for targeting CBT on the appearance of early signs of relapse in schizophrenia. The results are discussed in context of the study's methodological limitations.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>12701663</pmid><doi>10.1017/S0033291703007323</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-2917 |
| ispartof | Psychological medicine, 2003-04, Vol.33 (3), p.419-431 |
| issn | 0033-2917 1469-8978 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73217841 |
| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Cambridge University Press Journals Complete |
| subjects | Behavior therapy. Cognitive therapy Biological and medical sciences Cognitive Behavioral Therapy Cognitive behaviour therapy Crisis Intervention Early Female Humans Interventions Male Medical sciences Patients Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Randomized controlled trials Recurrence Relapse Schizophrenia Schizophrenia - prevention & control Schizophrenia - therapy Schizophrenic Psychology Scotland Time Factors Treatment Outcome Treatments |
| title | Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T14%3A26%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20intervention%20for%20relapse%20in%20schizophrenia:%20results%20of%20a%2012-month%20randomized%20controlled%20trial%20of%20cognitive%20behavioural%20therapy&rft.jtitle=Psychological%20medicine&rft.au=GUMLEY,%20A.&rft.date=2003-04-01&rft.volume=33&rft.issue=3&rft.spage=419&rft.epage=431&rft.pages=419-431&rft.issn=0033-2917&rft.eissn=1469-8978&rft.coden=PSMDCO&rft_id=info:doi/10.1017/S0033291703007323&rft_dat=%3Cproquest_cross%3E57147875%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204503484&rft_id=info:pmid/12701663&rft_cupid=10_1017_S0033291703007323&rfr_iscdi=true |