Changes in enzyme expression related to differentiation and regulatory factors: the acid phosphatase of osteoclasts and other macrophages
Human tartrate-resistant Type 5 acid phosphatase is a unique isoenzyme encoded by a gene located on chromosome 19. It is a member of a widely-distributed and structurally highly-conserved group of iron-containing proteins. It is normally expressed in certain tissue macrophages, notably osteoclasts a...
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| Veröffentlicht in: | Clinica chimica acta 1992-07, Vol.209 (1), p.131-138 |
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| creator | Moss, Donald W. |
| description | Human tartrate-resistant Type 5 acid phosphatase is a unique isoenzyme encoded by a gene located on chromosome 19. It is a member of a widely-distributed and structurally highly-conserved group of iron-containing proteins. It is normally expressed in certain tissue macrophages, notably osteoclasts and alveolar macrophages, but is virtually absent from the precursor monocytes. Factors which enhance or inhibit expression of this specific isoenzyme can be studied in monocytes and osteoclasts cultured in vitro. This provides opportunities to develop the use of Type 5 acid phosphatase as a reporter of pathophysiological events and an essential, though not sufficient, role in bone resorption by osteoclasts has been established by such studies. |
| doi_str_mv | 10.1016/0009-8981(92)90344-P |
| format | Article |
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This provides opportunities to develop the use of Type 5 acid phosphatase as a reporter of pathophysiological events and an essential, though not sufficient, role in bone resorption by osteoclasts has been established by such studies.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(92)90344-P</identifier><identifier>PMID: 1395035</identifier><identifier>CODEN: CCATAR</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acid phosphatase ; Acid Phosphatase - biosynthesis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Bone resorption ; Cell Differentiation ; Enzymes - biosynthesis ; Enzymes and enzyme inhibitors ; Expression ; Fundamental and applied biological sciences. 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This provides opportunities to develop the use of Type 5 acid phosphatase as a reporter of pathophysiological events and an essential, though not sufficient, role in bone resorption by osteoclasts has been established by such studies.</description><subject>Acid phosphatase</subject><subject>Acid Phosphatase - biosynthesis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Bone resorption</subject><subject>Cell Differentiation</subject><subject>Enzymes - biosynthesis</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Expression</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hydrolases</subject><subject>Macrophages</subject><subject>Macrophages - enzymology</subject><subject>Osteoclasts</subject><subject>Osteoclasts - enzymology</subject><subject>Regulation</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoY8_oGyhkITIuSpP6TWYhSOMfDDgLXYdUcjMdqUrK3LTYvoFvbWq6GXeuLpfzncvhXEKecfaaM96_YYzJSkjBL2X9SrKmbaubB2TDxdBUTSvrh2Rzjzwm54jfy9qynp-RM97IjjXdhvzZ7nS4BaQ-UAi_DzNQ-LUkQPQx0ASTzmBpjtR65yBByF7nVdLBFvl2X4CYDtRpUyZe0bwDqo23dNlFXHY6awQaHY2YIZpJY8Y7byxgorM2KRaqJHhCHjk9ITw9zQvy7cP7r9tP1fWXj5-3764r04g-Vw4kmAFAcC2EY9K2AvTIOfSO93xkdS-h5dbqjg-shdF1YuxhMHzsOhhG3lyQl8e7S4o_9oBZzR4NTJMOEPeohqbmfSNWsD2CJSJiAqeW5GedDooztX5ArfWqtV4la3X3AXVTbM9P9_fjDPaf6Vh50V-cdI1GTy7pYDzeY1071PVQF-ztEYPSxU8PSaHxEAxYn8BkZaP_f46_G8SmFA</recordid><startdate>19920731</startdate><enddate>19920731</enddate><creator>Moss, Donald W.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920731</creationdate><title>Changes in enzyme expression related to differentiation and regulatory factors: the acid phosphatase of osteoclasts and other macrophages</title><author>Moss, Donald W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-fe9ec7ee81a88f09d48eab11e6f161b0269e41dda51704ebf58b6e7c1b55e7b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acid phosphatase</topic><topic>Acid Phosphatase - biosynthesis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Bone resorption</topic><topic>Cell Differentiation</topic><topic>Enzymes - biosynthesis</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Expression</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hydrolases</topic><topic>Macrophages</topic><topic>Macrophages - enzymology</topic><topic>Osteoclasts</topic><topic>Osteoclasts - enzymology</topic><topic>Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moss, Donald W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moss, Donald W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in enzyme expression related to differentiation and regulatory factors: the acid phosphatase of osteoclasts and other macrophages</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1992-07-31</date><risdate>1992</risdate><volume>209</volume><issue>1</issue><spage>131</spage><epage>138</epage><pages>131-138</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><coden>CCATAR</coden><abstract>Human tartrate-resistant Type 5 acid phosphatase is a unique isoenzyme encoded by a gene located on chromosome 19. It is a member of a widely-distributed and structurally highly-conserved group of iron-containing proteins. It is normally expressed in certain tissue macrophages, notably osteoclasts and alveolar macrophages, but is virtually absent from the precursor monocytes. Factors which enhance or inhibit expression of this specific isoenzyme can be studied in monocytes and osteoclasts cultured in vitro. This provides opportunities to develop the use of Type 5 acid phosphatase as a reporter of pathophysiological events and an essential, though not sufficient, role in bone resorption by osteoclasts has been established by such studies.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>1395035</pmid><doi>10.1016/0009-8981(92)90344-P</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinica chimica acta, 1992-07, Vol.209 (1), p.131-138 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acid phosphatase Acid Phosphatase - biosynthesis Analytical, structural and metabolic biochemistry Biological and medical sciences Bone resorption Cell Differentiation Enzymes - biosynthesis Enzymes and enzyme inhibitors Expression Fundamental and applied biological sciences. Psychology Humans Hydrolases Macrophages Macrophages - enzymology Osteoclasts Osteoclasts - enzymology Regulation |
| title | Changes in enzyme expression related to differentiation and regulatory factors: the acid phosphatase of osteoclasts and other macrophages |
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