Cloning and sequencing of a 1.3 kb variant of human thyrotropin receptor mRNA lacking the transmembrane domain

We amplified human thyroidal cDNA using oligonucleotide primers designed to reveal putative human thyrotropin receptor (hTSHR) mRNA variants encoding the extracellular, ligand-binding domain but lacking the transmembrane domain. Whereas the major 4.3 kb hTSHR mRNA species was not amplified to detect...

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Veröffentlicht in:	Biochemical and biophysical research communications 1992-09, Vol.187 (2), p.1135-1143
Hauptverfasser:	Graves, Peter N., Tomer, Yaron, Davies, Terry F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biological and medical sciences Blotting, Northern cDNA Cell Membrane - metabolism Cell receptors Cell structures and functions Cloning, Molecular DNA - chemistry Fundamental and applied biological sciences. Psychology genes Genetic Variation Graves Disease - metabolism Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans man Molecular and cellular biology Molecular Sequence Data Nucleic Acid Hybridization nucleotide sequence Polymerase Chain Reaction receptors Receptors, Thyrotropin - chemistry Receptors, Thyrotropin - genetics RNA, Messenger - analysis RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Nucleic Acid Thyroid Gland - chemistry thyrotropin variants
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