Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability
A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics. A pyridyl moiety was introduced into a previously developed series of farnesyltransfer...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2003-05, Vol.13 (9), p.1571-1574 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Tong, Yunsong Lin, Nan-Horng Wang, Le Hasvold, Lisa Wang, Weibo Leonard, Nicholas Li, Tongmei Li, Qun Cohen, Jerry Gu, Wen-Zhen Zhang, Haiying Stoll, Vincent Bauch, Joy Marsh, Kennan Rosenberg, Saul H. Sham, Hing L. |
| description | A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as
4), resulting in potent inhibitors with improved pharmacokinetics.
A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl, resulting in potent inhibitors with improved pharmacokinetics. |
| doi_str_mv | 10.1016/S0960-894X(03)00195-1 |
| format | Article |
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4), resulting in potent inhibitors with improved pharmacokinetics.
A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl, resulting in potent inhibitors with improved pharmacokinetics.</description><subject>Administration, Oral</subject><subject>Alkyl and Aryl Transferases - antagonists & inhibitors</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Crystallography, X-Ray</subject><subject>Dogs</subject><subject>Drug Design</subject><subject>Enzyme Inhibitors - chemical synthesis</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Farnesyltranstransferase</subject><subject>General aspects</subject><subject>Haplorhini</subject><subject>Imidazoles - chemical synthesis</subject><subject>Imidazoles - chemistry</subject><subject>Imidazoles - pharmacology</subject><subject>Medical sciences</subject><subject>Models, Molecular</subject><subject>Nitriles - chemical synthesis</subject><subject>Nitriles - chemistry</subject><subject>Nitriles - pharmacology</subject><subject>Pharmacology. 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A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl, resulting in potent inhibitors with improved pharmacokinetics.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12699757</pmid><doi>10.1016/S0960-894X(03)00195-1</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (9), p.1571-1574 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Administration, Oral Alkyl and Aryl Transferases - antagonists & inhibitors Animals Antineoplastic agents Biological and medical sciences Biological Availability Crystallography, X-Ray Dogs Drug Design Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Farnesyltranstransferase General aspects Haplorhini Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Medical sciences Models, Molecular Nitriles - chemical synthesis Nitriles - chemistry Nitriles - pharmacology Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship |
| title | Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability |
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