Efficacy of dendrimer‐mediated angiostatin and TIMP‐2 gene delivery on inhibition of tumor growth and angiogenesis: In vitro and in vivo studies

Gene transfer is an attractive approach to fight cancer by targeting cancer cells or their vasculature. Our study reports the inhibition of tumor growth and angiogenesis by a nonviral method using dendrimers associated with 36‐mer anionic oligomers (ON36) for delivering angiostatin (Kringle 1–3) and...

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Veröffentlicht in:	International journal of cancer 2003-06, Vol.105 (3), p.419-429
Hauptverfasser:	Vincent, Loïc, Varet, Julia, Pille, Jean‐Yves, Bompais, Heidi, Opolon, Paule, Maksimenko, Andrei, Malvy, Claude, Mirshahi, Manouchehr, Lu, He, Vannier, Jean‐Pierre, Soria, Claudine, Li, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis angiostatin Angiostatins Animals Biological and medical sciences Blotting, Western cancer Cell Division Collagen - pharmacology Cytokines - metabolism dendrimer Drug Combinations Endothelium - cytology Flow Cytometry gene therapy Gene Transfer Techniques Genetic Therapy - methods Green Fluorescent Proteins Humans Laminin - pharmacology Luminescent Proteins - metabolism Medical sciences Mice Mice, Nude Neoplasms, Experimental - therapy Neovascularization, Pathologic Other treatments Peptide Fragments - genetics Peptide Fragments - therapeutic use Plasmids - metabolism Plasminogen - genetics Plasminogen - therapeutic use Proteoglycans - pharmacology Time Factors TIMP‐2 Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - therapeutic use Transfection Treatment. General aspects Tumor Cells, Cultured Tumors Wound Healing
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