Renal Handling of Urate in Two Patients with Hyperuricemia and Primary Hyperparathyroidism
Two patients with primary hyperparathyroidism had hyperuricemia due to the decrease in urate clearance. In analysis by 4-component model system, the tubular secretion of urate commonly decreased without changes in either filtered urate or presecretory reabsorption of urate. Both patients had a reduc...
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| Veröffentlicht in: | Internal Medicine 1992, Vol.31(6), pp.807-811 |
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| creator | HISATOME, Ichiro ISHIMURA, Masahiko SASAKI, Norito YAMAKAWA, Masayuki KOSAKA, Hiromoto TANAKA, Yasushi KOUCHI, Tetsuo MITANI, Yasuo YOSHIDA, Akio KOTAKE, Hiroshi SHIGEMASA, Chiaki MASHIBA, Hiroto |
| description | Two patients with primary hyperparathyroidism had hyperuricemia due to the decrease in urate clearance. In analysis by 4-component model system, the tubular secretion of urate commonly decreased without changes in either filtered urate or presecretory reabsorption of urate. Both patients had a reduction of urea clearance, and both parathyroidectomy in the former case and intravenous infusion of saline in the latter case could reduce the serum urate level associated with the increase in the ratio of urate clearance to creatinine clearance. It is of interest that the former case with a higher serum urate level had a relatively higher postsecretory reabsorption, even with the decrease in tubular secretion of urate. However, the latter patient with a lower serum urate level had a decrease in postsecretory reabsorption of urate in proportion to the decrease in tubular secretion. These results suggest that in hyperuricemia patients with primary hyperparathyroidism, the reduction of tubular urate secretion via hypoperfusion of the capillary network is typically present, however, the severity of the hyperuricemia might be dependent on the dysfunction of the postsecretory reabsorption of urate. (Internal Medicine 31 : 807-811, 1992) |
| doi_str_mv | 10.2169/internalmedicine.31.807 |
| format | Article |
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In analysis by 4-component model system, the tubular secretion of urate commonly decreased without changes in either filtered urate or presecretory reabsorption of urate. Both patients had a reduction of urea clearance, and both parathyroidectomy in the former case and intravenous infusion of saline in the latter case could reduce the serum urate level associated with the increase in the ratio of urate clearance to creatinine clearance. It is of interest that the former case with a higher serum urate level had a relatively higher postsecretory reabsorption, even with the decrease in tubular secretion of urate. However, the latter patient with a lower serum urate level had a decrease in postsecretory reabsorption of urate in proportion to the decrease in tubular secretion. These results suggest that in hyperuricemia patients with primary hyperparathyroidism, the reduction of tubular urate secretion via hypoperfusion of the capillary network is typically present, however, the severity of the hyperuricemia might be dependent on the dysfunction of the postsecretory reabsorption of urate. (Internal Medicine 31 : 807-811, 1992)</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.31.807</identifier><identifier>PMID: 1392185</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; Female ; Humans ; Hyperparathyroidism - diagnosis ; Hyperparathyroidism - metabolism ; Kidney - metabolism ; Kidney Tubules - metabolism ; Male ; postsecretory reabsorption of urate ; Probenecid ; Pyrazinamide ; tubular secretion of urate ; Uric Acid - blood ; Uric Acid - metabolism ; volume contraction</subject><ispartof>Internal Medicine, 1992, Vol.31(6), pp.807-811</ispartof><rights>The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4117-144b30c325025e88b97827e8176d3655790399356487294b8ad9c59821f276f73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1392185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HISATOME, Ichiro</creatorcontrib><creatorcontrib>ISHIMURA, Masahiko</creatorcontrib><creatorcontrib>SASAKI, Norito</creatorcontrib><creatorcontrib>YAMAKAWA, Masayuki</creatorcontrib><creatorcontrib>KOSAKA, Hiromoto</creatorcontrib><creatorcontrib>TANAKA, Yasushi</creatorcontrib><creatorcontrib>KOUCHI, Tetsuo</creatorcontrib><creatorcontrib>MITANI, Yasuo</creatorcontrib><creatorcontrib>YOSHIDA, Akio</creatorcontrib><creatorcontrib>KOTAKE, Hiroshi</creatorcontrib><creatorcontrib>SHIGEMASA, Chiaki</creatorcontrib><creatorcontrib>MASHIBA, Hiroto</creatorcontrib><title>Renal Handling of Urate in Two Patients with Hyperuricemia and Primary Hyperparathyroidism</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Two patients with primary hyperparathyroidism had hyperuricemia due to the decrease in urate clearance. In analysis by 4-component model system, the tubular secretion of urate commonly decreased without changes in either filtered urate or presecretory reabsorption of urate. Both patients had a reduction of urea clearance, and both parathyroidectomy in the former case and intravenous infusion of saline in the latter case could reduce the serum urate level associated with the increase in the ratio of urate clearance to creatinine clearance. It is of interest that the former case with a higher serum urate level had a relatively higher postsecretory reabsorption, even with the decrease in tubular secretion of urate. However, the latter patient with a lower serum urate level had a decrease in postsecretory reabsorption of urate in proportion to the decrease in tubular secretion. These results suggest that in hyperuricemia patients with primary hyperparathyroidism, the reduction of tubular urate secretion via hypoperfusion of the capillary network is typically present, however, the severity of the hyperuricemia might be dependent on the dysfunction of the postsecretory reabsorption of urate. (Internal Medicine 31 : 807-811, 1992)</description><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperparathyroidism - diagnosis</subject><subject>Hyperparathyroidism - metabolism</subject><subject>Kidney - metabolism</subject><subject>Kidney Tubules - metabolism</subject><subject>Male</subject><subject>postsecretory reabsorption of urate</subject><subject>Probenecid</subject><subject>Pyrazinamide</subject><subject>tubular secretion of urate</subject><subject>Uric Acid - blood</subject><subject>Uric Acid - metabolism</subject><subject>volume contraction</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEFP3DAQha2qFV1ofwLCJ25ZPHYc28cKAYuExKqCSy-W15mwRomztbNC--8xCqISvcwcvvfejB4hZ8CWHBpzEeKEKbp-wDb4EHEpYKmZ-kIWIGpTKS7kV7JgBnTFy_hOjnN-ZkxoZfgROQJhOGi5IH9-Y0mhKxfbPsQnOnb0MbkJaYj04WWkazcFjFOmL2Ha0tVhh2mfgschOFo8dJ3C4NJhJjtXrNtDGkMb8vCDfOtcn_Hn-z4hj9dXD5er6u7-5vby113lawBVQV1vBPOCS8Ylar0xSnOFGlTTikZKZZgwRsim1oqbeqNda7w0mkPHVdMpcULO59xdGv_uMU92CNlj37uI4z5bJThIAawI1Sz0acw5YWd38_cWmH1r1X5u1QqwpdXiPH0_sd8U9s8311j4eubPeXJP-MFdmoLv8b9cMIa_ZTfzKCc-pH7rksUoXgHUxJTW</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>HISATOME, Ichiro</creator><creator>ISHIMURA, Masahiko</creator><creator>SASAKI, Norito</creator><creator>YAMAKAWA, Masayuki</creator><creator>KOSAKA, Hiromoto</creator><creator>TANAKA, Yasushi</creator><creator>KOUCHI, Tetsuo</creator><creator>MITANI, Yasuo</creator><creator>YOSHIDA, Akio</creator><creator>KOTAKE, Hiroshi</creator><creator>SHIGEMASA, Chiaki</creator><creator>MASHIBA, Hiroto</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Renal Handling of Urate in Two Patients with Hyperuricemia and Primary Hyperparathyroidism</title><author>HISATOME, Ichiro ; ISHIMURA, Masahiko ; SASAKI, Norito ; YAMAKAWA, Masayuki ; KOSAKA, Hiromoto ; TANAKA, Yasushi ; KOUCHI, Tetsuo ; MITANI, Yasuo ; YOSHIDA, Akio ; KOTAKE, Hiroshi ; SHIGEMASA, Chiaki ; MASHIBA, Hiroto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4117-144b30c325025e88b97827e8176d3655790399356487294b8ad9c59821f276f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperparathyroidism - diagnosis</topic><topic>Hyperparathyroidism - metabolism</topic><topic>Kidney - metabolism</topic><topic>Kidney Tubules - metabolism</topic><topic>Male</topic><topic>postsecretory reabsorption of urate</topic><topic>Probenecid</topic><topic>Pyrazinamide</topic><topic>tubular secretion of urate</topic><topic>Uric Acid - blood</topic><topic>Uric Acid - metabolism</topic><topic>volume contraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HISATOME, Ichiro</creatorcontrib><creatorcontrib>ISHIMURA, Masahiko</creatorcontrib><creatorcontrib>SASAKI, Norito</creatorcontrib><creatorcontrib>YAMAKAWA, Masayuki</creatorcontrib><creatorcontrib>KOSAKA, Hiromoto</creatorcontrib><creatorcontrib>TANAKA, Yasushi</creatorcontrib><creatorcontrib>KOUCHI, Tetsuo</creatorcontrib><creatorcontrib>MITANI, Yasuo</creatorcontrib><creatorcontrib>YOSHIDA, Akio</creatorcontrib><creatorcontrib>KOTAKE, Hiroshi</creatorcontrib><creatorcontrib>SHIGEMASA, Chiaki</creatorcontrib><creatorcontrib>MASHIBA, Hiroto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HISATOME, Ichiro</au><au>ISHIMURA, Masahiko</au><au>SASAKI, Norito</au><au>YAMAKAWA, Masayuki</au><au>KOSAKA, Hiromoto</au><au>TANAKA, Yasushi</au><au>KOUCHI, Tetsuo</au><au>MITANI, Yasuo</au><au>YOSHIDA, Akio</au><au>KOTAKE, Hiroshi</au><au>SHIGEMASA, Chiaki</au><au>MASHIBA, Hiroto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Handling of Urate in Two Patients with Hyperuricemia and Primary Hyperparathyroidism</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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However, the latter patient with a lower serum urate level had a decrease in postsecretory reabsorption of urate in proportion to the decrease in tubular secretion. These results suggest that in hyperuricemia patients with primary hyperparathyroidism, the reduction of tubular urate secretion via hypoperfusion of the capillary network is typically present, however, the severity of the hyperuricemia might be dependent on the dysfunction of the postsecretory reabsorption of urate. (Internal Medicine 31 : 807-811, 1992)</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>1392185</pmid><doi>10.2169/internalmedicine.31.807</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Internal Medicine, 1992, Vol.31(6), pp.807-811 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Female Humans Hyperparathyroidism - diagnosis Hyperparathyroidism - metabolism Kidney - metabolism Kidney Tubules - metabolism Male postsecretory reabsorption of urate Probenecid Pyrazinamide tubular secretion of urate Uric Acid - blood Uric Acid - metabolism volume contraction |
| title | Renal Handling of Urate in Two Patients with Hyperuricemia and Primary Hyperparathyroidism |
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