Mental and physical state in subclinical hyperthyroidism: Investigations in a normal working population
We investigated whether subclinically hyperthyroid individuals selected from a nonpatient working population exhibit similar impairments to those found in studies with patients. Sixteen subclinically hyperthyroid subjects without apparent reason (SH-0) and 15 subclinically hyperthyroid subjects on l...
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| Veröffentlicht in: | Biological psychiatry (1969) 1992-07, Vol.32 (1), p.48-56 |
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| container_title | Biological psychiatry (1969) |
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| creator | Schlote, Barbara Schaaf, Ludwig Schmidt, Roland Pohl, Tilla Vardarli, Irfan Schiebeler, Henning Zober, Max Andreas Usadel, Klaus Henning |
| description | We investigated whether subclinically hyperthyroid individuals selected from a nonpatient working population exhibit similar impairments to those found in studies with patients. Sixteen subclinically hyperthyroid subjects without apparent reason (SH-0) and 15 subclinically hyperthyroid subjects on levothyroxine (SH-T4) were compared with 27 euthyroid controls with respect to signs and symptoms of hyperthyroidism, sleep, depressivity, ability to concentrate, anxiety, and other dimensions of well-being. We found that SH-T4 exhibited significantly higher TT4 levels, TT4/TBG ratios, and more palpititions than controls. Furthermore, they slept less. The SH-0 subjects reported being in a better mood and less touchy than controls. Psychometric results of all groups were within the normal range. A comparison of this study to previous studies reveals that TT4 levels or TT4/TBG ratios may play a crucial role in the development of the predominantly nervous symptoms in subclinical hyperthyroidism. Possible reasons for the discrepancies between results in hospital and nonhospital settings are discussed. |
| doi_str_mv | 10.1016/0006-3223(92)90141-L |
| format | Article |
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Sixteen subclinically hyperthyroid subjects without apparent reason (SH-0) and 15 subclinically hyperthyroid subjects on levothyroxine (SH-T4) were compared with 27 euthyroid controls with respect to signs and symptoms of hyperthyroidism, sleep, depressivity, ability to concentrate, anxiety, and other dimensions of well-being. We found that SH-T4 exhibited significantly higher TT4 levels, TT4/TBG ratios, and more palpititions than controls. Furthermore, they slept less. The SH-0 subjects reported being in a better mood and less touchy than controls. Psychometric results of all groups were within the normal range. A comparison of this study to previous studies reveals that TT4 levels or TT4/TBG ratios may play a crucial role in the development of the predominantly nervous symptoms in subclinical hyperthyroidism. Possible reasons for the discrepancies between results in hospital and nonhospital settings are discussed.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/0006-3223(92)90141-L</identifier><identifier>PMID: 1391296</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Arousal - physiology ; Biological and medical sciences ; Endocrinopathies ; Female ; Humans ; Hyperthyroidism - diagnosis ; Hyperthyroidism - prevention & control ; Hyperthyroidism - psychology ; Male ; Mass Screening ; Medical sciences ; Neurocognitive Disorders - diagnosis ; Neurocognitive Disorders - psychology ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Personality Inventory ; Sick Role ; Sleep Stages - physiology ; Thyroid Hormones - blood ; Thyroid. 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Sixteen subclinically hyperthyroid subjects without apparent reason (SH-0) and 15 subclinically hyperthyroid subjects on levothyroxine (SH-T4) were compared with 27 euthyroid controls with respect to signs and symptoms of hyperthyroidism, sleep, depressivity, ability to concentrate, anxiety, and other dimensions of well-being. We found that SH-T4 exhibited significantly higher TT4 levels, TT4/TBG ratios, and more palpititions than controls. Furthermore, they slept less. The SH-0 subjects reported being in a better mood and less touchy than controls. Psychometric results of all groups were within the normal range. A comparison of this study to previous studies reveals that TT4 levels or TT4/TBG ratios may play a crucial role in the development of the predominantly nervous symptoms in subclinical hyperthyroidism. Possible reasons for the discrepancies between results in hospital and nonhospital settings are discussed.</description><subject>Adult</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperthyroidism - diagnosis</subject><subject>Hyperthyroidism - prevention & control</subject><subject>Hyperthyroidism - psychology</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Neurocognitive Disorders - diagnosis</subject><subject>Neurocognitive Disorders - psychology</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Personality Inventory</subject><subject>Sick Role</subject><subject>Sleep Stages - physiology</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyrotropin - blood</subject><subject>Thyrotropin-Releasing Hormone</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtr3DAQh0VoSTeP_6AFH0pJD270srTKoVBCH4ENuSRnMZbkXbW25Ep2yv731T5Ibz0NM79vhuFD6C3Bnwgm4hpjLGpGKbtS9KPChJN6dYIWZClZTTmmr9DiBXmDznL-WVpJKTlFp4QpQpVYoPW9CxP0FQRbjZtt9qY0eYLJVT5UeW5N78N-uNmOLk2bbYre-jzcVHfh2eXJr2HyMeQdDlWIaSjsn5h--bCuxjjO_T6_QK876LO7PNZz9PTt6-Ptj3r18P3u9suqNryhU83lErdMgjCSNpZzTm0rnFRc4c6Co6IBYC1TGBQYKsgSM24Jlp2wRijo2Dn6cLg7pvh7Lv_pwWfj-h6Ci3PWklHSYKIKyA-gSTHn5Do9Jj9A2mqC9c6v3snTO3laUb33q1dl7d3x_twOzv5bOggt-ftjDrlY6xIE4_ML1gjMl0oW7PMBc8XFs3dJZ-NdMM765MykbfT__-MvzY-X-A</recordid><startdate>19920701</startdate><enddate>19920701</enddate><creator>Schlote, Barbara</creator><creator>Schaaf, Ludwig</creator><creator>Schmidt, Roland</creator><creator>Pohl, Tilla</creator><creator>Vardarli, Irfan</creator><creator>Schiebeler, Henning</creator><creator>Zober, Max Andreas</creator><creator>Usadel, Klaus Henning</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920701</creationdate><title>Mental and physical state in subclinical hyperthyroidism: Investigations in a normal working population</title><author>Schlote, Barbara ; Schaaf, Ludwig ; Schmidt, Roland ; Pohl, Tilla ; Vardarli, Irfan ; Schiebeler, Henning ; Zober, Max Andreas ; Usadel, Klaus Henning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-4780b37a6c725d4442db6e79490fdae265aa3b390a9ac2618034d107f6dc69af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Arousal - physiology</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperthyroidism - diagnosis</topic><topic>Hyperthyroidism - prevention & control</topic><topic>Hyperthyroidism - psychology</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Neurocognitive Disorders - diagnosis</topic><topic>Neurocognitive Disorders - psychology</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Personality Inventory</topic><topic>Sick Role</topic><topic>Sleep Stages - physiology</topic><topic>Thyroid Hormones - blood</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyrotropin - blood</topic><topic>Thyrotropin-Releasing Hormone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schlote, Barbara</creatorcontrib><creatorcontrib>Schaaf, Ludwig</creatorcontrib><creatorcontrib>Schmidt, Roland</creatorcontrib><creatorcontrib>Pohl, Tilla</creatorcontrib><creatorcontrib>Vardarli, Irfan</creatorcontrib><creatorcontrib>Schiebeler, Henning</creatorcontrib><creatorcontrib>Zober, Max Andreas</creatorcontrib><creatorcontrib>Usadel, Klaus Henning</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schlote, Barbara</au><au>Schaaf, Ludwig</au><au>Schmidt, Roland</au><au>Pohl, Tilla</au><au>Vardarli, Irfan</au><au>Schiebeler, Henning</au><au>Zober, Max Andreas</au><au>Usadel, Klaus Henning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mental and physical state in subclinical hyperthyroidism: Investigations in a normal working population</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>32</volume><issue>1</issue><spage>48</spage><epage>56</epage><pages>48-56</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>We investigated whether subclinically hyperthyroid individuals selected from a nonpatient working population exhibit similar impairments to those found in studies with patients. Sixteen subclinically hyperthyroid subjects without apparent reason (SH-0) and 15 subclinically hyperthyroid subjects on levothyroxine (SH-T4) were compared with 27 euthyroid controls with respect to signs and symptoms of hyperthyroidism, sleep, depressivity, ability to concentrate, anxiety, and other dimensions of well-being. We found that SH-T4 exhibited significantly higher TT4 levels, TT4/TBG ratios, and more palpititions than controls. Furthermore, they slept less. The SH-0 subjects reported being in a better mood and less touchy than controls. Psychometric results of all groups were within the normal range. A comparison of this study to previous studies reveals that TT4 levels or TT4/TBG ratios may play a crucial role in the development of the predominantly nervous symptoms in subclinical hyperthyroidism. Possible reasons for the discrepancies between results in hospital and nonhospital settings are discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1391296</pmid><doi>10.1016/0006-3223(92)90141-L</doi><tpages>9</tpages></addata></record> |
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| ispartof | Biological psychiatry (1969), 1992-07, Vol.32 (1), p.48-56 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Arousal - physiology Biological and medical sciences Endocrinopathies Female Humans Hyperthyroidism - diagnosis Hyperthyroidism - prevention & control Hyperthyroidism - psychology Male Mass Screening Medical sciences Neurocognitive Disorders - diagnosis Neurocognitive Disorders - psychology Non tumoral diseases. Target tissue resistance. Benign neoplasms Personality Inventory Sick Role Sleep Stages - physiology Thyroid Hormones - blood Thyroid. Thyroid axis (diseases) Thyrotropin - blood Thyrotropin-Releasing Hormone |
| title | Mental and physical state in subclinical hyperthyroidism: Investigations in a normal working population |
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