The alpha 1-adrenoceptor is inactivated by alterations in membrane phospholipids

The influence of the membrane environment on the alpha 1-adrenoceptor has been investigated by examining the effect of phospholipase digestion on the binding of [3H]prazosin to aortic and hepatic membranes. Membrane digestion by phospholipase A2 and phospholipase C was found to markedly reduce prazo...

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Veröffentlicht in:	European journal of pharmacology 1992-05, Vol.226 (1), p.29-33
Hauptverfasser:	Shreeve, S M, Valliere, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Binding Sites Cell Membrane - chemistry Liver - metabolism Male Membrane Lipids - chemistry Membrane Lipids - metabolism Muscle, Smooth, Vascular - metabolism Phospholipases A - metabolism Phospholipases A2 Phospholipids - chemistry Phospholipids - metabolism Prazosin - metabolism Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha - chemistry Receptors, Adrenergic, alpha - metabolism Type C Phospholipases - metabolism
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