ANTHRACYCLINE METABOLITES FROM BAUMYCIN-PRODUCING Streptomyces sp. D788: I. ISOLATION OF ANTIBIOTIC-BLOCKED MUTANTS AND THEIR CHARACTERIZATION

Biosynthetically blocked mutants were obtained from a baumycin-producing Streptomyces sp. D788 newly isolated from soil. The first mutant isolated was a baumycin-negative but daunorubicin-accumulating mutant with a loss of 4'-substitution activity, from which all other blocked mutants were succ...

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Veröffentlicht in:	Journal of antibiotics 1992/08/25, Vol.45(8), pp.1255-1267
Hauptverfasser:	YOSHIMOTO, AKIHIRO, JOHDO, OSAMU, FUJII, SHIZUKA, KUBO, KATSUROU, NISHIDA, HIROSHI, OKAMOTO, ROKURO, TAKEUCHI, TOMIO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Chromatography, High Pressure Liquid Daunorubicin - analogs & derivatives Daunorubicin - biosynthesis Fundamental and applied biological sciences. Psychology Leukemia L1210 - pathology Mice Microbiology Mutation Streptomyces Streptomyces - genetics Streptomyces - metabolism Tumor Cells, Cultured - drug effects
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