Correction of Defects Responsible for Impaired Qa-2 Class Ib MHC Expression on Melanoma Cells Protects Mice from Tumor Growth

One of the principal mechanisms of tumor immune evasion is alteration of class I MHC expression. We have identified defects contributing to down-regulation of class I MHC expression in the widely studied murine B16 melanoma and its variants B16F1, B16F10, BL6-2, BL6-8 and B78H1. Transcription of the...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-05, Vol.170 (9), p.4515-4523
Hauptverfasser:	Chiang, Eugene Y, Henson, Maile, Stroynowski, Iwona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - genetics ATP Binding Cassette Transporter, Subfamily B, Member 3 ATP-Binding Cassette Transporters - genetics CD8-Positive T-Lymphocytes - immunology Cell Division - genetics Cell Division - immunology Cell Line, Transformed Down-Regulation - genetics Down-Regulation - immunology Genetic Vectors Granulocyte-Macrophage Colony-Stimulating Factor - genetics Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - immunology Killer Cells, Natural - immunology Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - prevention & control Mice Mice, Inbred C57BL Neoplasm Transplantation Transduction, Genetic - methods Transfection Tumor Cells, Cultured
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