Cefodizime stimulates subpopulations of cells mediating spontaneous or antibody-dependent cytotoxicity in patients with bacterial infections
The influence of cefodizime (CDZ) on spontaneous cell-mediated cytotoxicity (SCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) was investigated in nine patients with conditions predisposing to infection (T-cell deficiency, humoral immune deficiency, myeloproliferative syndrome, kidney o...
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| Veröffentlicht in: | Infection 1992, Vol.20 Suppl 1 (S1), p.S54-S57 |
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| container_end_page | S57 |
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| container_title | Infection |
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| creator | Auer, I O Hardörfer, C Zimmermann, I |
| description | The influence of cefodizime (CDZ) on spontaneous cell-mediated cytotoxicity (SCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) was investigated in nine patients with conditions predisposing to infection (T-cell deficiency, humoral immune deficiency, myeloproliferative syndrome, kidney or liver damage, or chronic pulmonary disease). SCMC, using the K562 and LIK cell lines as targets, and ADCC, using the LIK cell line, were measured at baseline and after ten days of therapy with CDZ for lower respiratory tract infections. Six patients were cured; clinical outcome was not evaluable in the other three. SCMC lysis of K562 cells did not change significantly. SCMC and ADCC lysis of LIK (lymphoblastoid) cells both increased significantly. CDZ selectively stimulated a subpopulation of NK cells in this population of immunocompromised patients with lower respiratory tract infections. |
| doi_str_mv | 10.1007/BF01709954 |
| format | Article |
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SCMC, using the K562 and LIK cell lines as targets, and ADCC, using the LIK cell line, were measured at baseline and after ten days of therapy with CDZ for lower respiratory tract infections. Six patients were cured; clinical outcome was not evaluable in the other three. SCMC lysis of K562 cells did not change significantly. SCMC and ADCC lysis of LIK (lymphoblastoid) cells both increased significantly. CDZ selectively stimulated a subpopulation of NK cells in this population of immunocompromised patients with lower respiratory tract infections.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/BF01709954</identifier><identifier>PMID: 1526679</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Antibody-Dependent Cell Cytotoxicity - drug effects ; Bacterial Infections - drug therapy ; Bacterial Infections - immunology ; Cefotaxime - analogs & derivatives ; Cefotaxime - pharmacology ; Cefotaxime - therapeutic use ; Cytotoxicity, Immunologic - drug effects ; Female ; Humans ; Immunologic Factors - pharmacology ; Male ; Middle Aged</subject><ispartof>Infection, 1992, Vol.20 Suppl 1 (S1), p.S54-S57</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c272t-606bc9bb341f5818468d0a1904759fc03475055ace5e08e356636ad1c9bb30413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1526679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auer, I O</creatorcontrib><creatorcontrib>Hardörfer, C</creatorcontrib><creatorcontrib>Zimmermann, I</creatorcontrib><title>Cefodizime stimulates subpopulations of cells mediating spontaneous or antibody-dependent cytotoxicity in patients with bacterial infections</title><title>Infection</title><addtitle>Infection</addtitle><description>The influence of cefodizime (CDZ) on spontaneous cell-mediated cytotoxicity (SCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) was investigated in nine patients with conditions predisposing to infection (T-cell deficiency, humoral immune deficiency, myeloproliferative syndrome, kidney or liver damage, or chronic pulmonary disease). SCMC, using the K562 and LIK cell lines as targets, and ADCC, using the LIK cell line, were measured at baseline and after ten days of therapy with CDZ for lower respiratory tract infections. Six patients were cured; clinical outcome was not evaluable in the other three. SCMC lysis of K562 cells did not change significantly. SCMC and ADCC lysis of LIK (lymphoblastoid) cells both increased significantly. CDZ selectively stimulated a subpopulation of NK cells in this population of immunocompromised patients with lower respiratory tract infections.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibody-Dependent Cell Cytotoxicity - drug effects</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - immunology</subject><subject>Cefotaxime - analogs & derivatives</subject><subject>Cefotaxime - pharmacology</subject><subject>Cefotaxime - therapeutic use</subject><subject>Cytotoxicity, Immunologic - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Immunologic Factors - pharmacology</subject><subject>Male</subject><subject>Middle Aged</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1PxDAMhiMEOo6PhR0pEwNSwWmatBnhxAESEgvMVZq6ENQ2pUkFx2_gR5O7Q2Jksuz3sS37JeSEwQUDyC-vl8ByUEpkO2TOMq4SUDnfJXPgAEnBUrlPDrx_AwChsnxGZkykUuZqTr4X2LjaftkOqQ-2m1od0FM_VYMb1ol1vaeuoQbb1tMOaxtr_Qv1g-uD7tFNUR6p7oOtXL1Kahywr7EP1KyCC-7TGhtW1PZ0iI2x7umHDa-00ibgaHUbpQbNZs8R2Wt06_H4Nx6S5-XN0-IueXi8vV9cPSQmzdOQSJCVUVXFM9aIghWZLGrQTEGWC9UY4DGCENqgQCiQCym51DXb9EDG-CE5284dRvc-oQ9lZ_36wO09Zc5TEAXIf0EmRVHEp0bwfAua0Xk_YlMOo-30uCoZlGuPyj-PInz6O3Wq4kP_0K0p_AcPjI8g</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Auer, I O</creator><creator>Hardörfer, C</creator><creator>Zimmermann, I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Cefodizime stimulates subpopulations of cells mediating spontaneous or antibody-dependent cytotoxicity in patients with bacterial infections</title><author>Auer, I O ; Hardörfer, C ; Zimmermann, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-606bc9bb341f5818468d0a1904759fc03475055ace5e08e356636ad1c9bb30413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibody-Dependent Cell Cytotoxicity - drug effects</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - immunology</topic><topic>Cefotaxime - analogs & derivatives</topic><topic>Cefotaxime - pharmacology</topic><topic>Cefotaxime - therapeutic use</topic><topic>Cytotoxicity, Immunologic - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Immunologic Factors - pharmacology</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auer, I O</creatorcontrib><creatorcontrib>Hardörfer, C</creatorcontrib><creatorcontrib>Zimmermann, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auer, I O</au><au>Hardörfer, C</au><au>Zimmermann, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cefodizime stimulates subpopulations of cells mediating spontaneous or antibody-dependent cytotoxicity in patients with bacterial infections</atitle><jtitle>Infection</jtitle><addtitle>Infection</addtitle><date>1992</date><risdate>1992</risdate><volume>20 Suppl 1</volume><issue>S1</issue><spage>S54</spage><epage>S57</epage><pages>S54-S57</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>The influence of cefodizime (CDZ) on spontaneous cell-mediated cytotoxicity (SCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) was investigated in nine patients with conditions predisposing to infection (T-cell deficiency, humoral immune deficiency, myeloproliferative syndrome, kidney or liver damage, or chronic pulmonary disease). 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| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 1992, Vol.20 Suppl 1 (S1), p.S54-S57 |
| issn | 0300-8126 1439-0973 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Antibody-Dependent Cell Cytotoxicity - drug effects Bacterial Infections - drug therapy Bacterial Infections - immunology Cefotaxime - analogs & derivatives Cefotaxime - pharmacology Cefotaxime - therapeutic use Cytotoxicity, Immunologic - drug effects Female Humans Immunologic Factors - pharmacology Male Middle Aged |
| title | Cefodizime stimulates subpopulations of cells mediating spontaneous or antibody-dependent cytotoxicity in patients with bacterial infections |
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