Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions
Background. Adhesion formation in the peritoneal cavity is the most common cause of intestinal obstruction and secondary female infertility. A great effort has been dedicated to reduce adhesion formation because of the associated morbidity and its complications. Materials and methods. This study was...
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| Veröffentlicht in: | The Journal of surgical research 2003-03, Vol.110 (1), p.207-210 |
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| creator | Cervantes-Sánchez, Carlos R Olaya, Enrique Testas, Manuel Garcia-López, Norberto Coste, Gabriel Arrellin, Gerardo Luna, Adrián Krötzsch, Fernando Edgar |
| description | Background. Adhesion formation in the peritoneal cavity is the most common cause of intestinal obstruction and secondary female infertility. A great effort has been dedicated to reduce adhesion formation because of the associated morbidity and its complications.
Materials and methods. This study was designed as a before-after comparative trial and included 14 rabbits, with a weight between 300 and 500 g. All rabbits were appendectomized and 1 month later laparotomized to assess adhesion formation. Rabbits were randomized into two groups, Group I (control group), with no intervention, and Group II (experimental group), treated with an intraperitoneal sponge of collagen-polyvinylpyrrolidone (Clg-PVP). The laparotomy procedure was repeated 1 month later for a new assessment of adhesion formation and histological evaluation by H-E and Masson staining.
Results. Histological findings showed abundant infiltrate in the control group, which was mild in the experimental group. With the Masson stain the control group showed a significantly higher amount of collagen than the experimental group and the fibrous tissue was more compact. We found a mean number of adhesions of 3.29 ± 1.98 for the control group, which decreased to 2.57 ± 0.79 after the second laparotomy. For the experimental group the mean number of adhesions decreased from 1.86 ± 0.90 to 0.71 ± 0.49 after the second laparotomy, with no statistical difference between both groups before Clg-PVP application, but a significant statistical difference after the implantation of Clg-PVP (Student’s
t test;
P < 0.001, two-tailed).
Conclusion. Collagen-polyvinylpyrrolidone decreases the incidence and size of intraabdominal adhesions after secondary adhesion formation after appendectomy. |
| doi_str_mv | 10.1016/S0022-4804(02)00099-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73204351</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022480402000999</els_id><sourcerecordid>73204351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c306t-cce3739021f3cf8a9cd110b7d357aa9b57c63846c9dc5e754e712f1410238bb3</originalsourceid><addsrcrecordid>eNqFkVFr1EAQxxdR7Fn9CEpeLBYand1NstknKYdthYIVi6_LZnaiK7nsuZMr9Nub6wX72Kdh4Df_GX4jxFsJHyXI5tMPAKXKqoXqA6hTALC2tM_ESoKty7Yx-rlY_UeOxCvmPzOkrNEvxZFUjTUVqJX4vk7D4H_RWN78vDkrfIFLX_D9OP0mjlxsUtgNfkr5rAiEmTwTF3Gcst9SjlMayQ-FD3s4jfxavOj9wPRmqcfi9uLL7fqqvP52-XV9fl2ihmYqEUkbbUHJXmPfeotBSuhM0LXx3na1wUa3VYM2YE2mrshI1ctKgtJt1-ljcXKI3eb0d0c8uU1kpPn4kdKOndEKKl3LGawPIObEnKl32xw3Pt87CW6v0j2odHtPDpR7UOnsPPduWbDrNhQepxZ3M_B-ATyjH_rsR4z8yFVmfoXZB30-cDTbuIuUHWOkESnETDi5kOITp_wDbS-QNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73204351</pqid></control><display><type>article</type><title>Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Cervantes-Sánchez, Carlos R ; Olaya, Enrique ; Testas, Manuel ; Garcia-López, Norberto ; Coste, Gabriel ; Arrellin, Gerardo ; Luna, Adrián ; Krötzsch, Fernando Edgar</creator><creatorcontrib>Cervantes-Sánchez, Carlos R ; Olaya, Enrique ; Testas, Manuel ; Garcia-López, Norberto ; Coste, Gabriel ; Arrellin, Gerardo ; Luna, Adrián ; Krötzsch, Fernando Edgar</creatorcontrib><description>Background. Adhesion formation in the peritoneal cavity is the most common cause of intestinal obstruction and secondary female infertility. A great effort has been dedicated to reduce adhesion formation because of the associated morbidity and its complications.
Materials and methods. This study was designed as a before-after comparative trial and included 14 rabbits, with a weight between 300 and 500 g. All rabbits were appendectomized and 1 month later laparotomized to assess adhesion formation. Rabbits were randomized into two groups, Group I (control group), with no intervention, and Group II (experimental group), treated with an intraperitoneal sponge of collagen-polyvinylpyrrolidone (Clg-PVP). The laparotomy procedure was repeated 1 month later for a new assessment of adhesion formation and histological evaluation by H-E and Masson staining.
Results. Histological findings showed abundant infiltrate in the control group, which was mild in the experimental group. With the Masson stain the control group showed a significantly higher amount of collagen than the experimental group and the fibrous tissue was more compact. We found a mean number of adhesions of 3.29 ± 1.98 for the control group, which decreased to 2.57 ± 0.79 after the second laparotomy. For the experimental group the mean number of adhesions decreased from 1.86 ± 0.90 to 0.71 ± 0.49 after the second laparotomy, with no statistical difference between both groups before Clg-PVP application, but a significant statistical difference after the implantation of Clg-PVP (Student’s
t test;
P < 0.001, two-tailed).
Conclusion. Collagen-polyvinylpyrrolidone decreases the incidence and size of intraabdominal adhesions after secondary adhesion formation after appendectomy.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/S0022-4804(02)00099-9</identifier><identifier>PMID: 12697402</identifier><identifier>CODEN: JSGRA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; appendectomy ; Appendectomy - adverse effects ; Biological and medical sciences ; Collagen - antagonists & inhibitors ; Collagen - biosynthesis ; Collagen - therapeutic use ; collagen-polyvinylpyrrolidone ; Female ; intraperitoneal adhesions ; Male ; Medical sciences ; Peritoneal Diseases - etiology ; Peritoneal Diseases - pathology ; Peritoneal Diseases - prevention & control ; Peritoneal Diseases - surgery ; Povidone - therapeutic use ; Rabbits ; Secondary Prevention ; Stomach, duodenum, intestine, rectum, anus ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Tissue Adhesions - etiology ; Tissue Adhesions - pathology ; Tissue Adhesions - prevention & control ; Tissue Adhesions - surgery</subject><ispartof>The Journal of surgical research, 2003-03, Vol.110 (1), p.207-210</ispartof><rights>2003 Elsevier Science (USA)</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c306t-cce3739021f3cf8a9cd110b7d357aa9b57c63846c9dc5e754e712f1410238bb3</citedby><cites>FETCH-LOGICAL-c306t-cce3739021f3cf8a9cd110b7d357aa9b57c63846c9dc5e754e712f1410238bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-4804(02)00099-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14709579$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12697402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cervantes-Sánchez, Carlos R</creatorcontrib><creatorcontrib>Olaya, Enrique</creatorcontrib><creatorcontrib>Testas, Manuel</creatorcontrib><creatorcontrib>Garcia-López, Norberto</creatorcontrib><creatorcontrib>Coste, Gabriel</creatorcontrib><creatorcontrib>Arrellin, Gerardo</creatorcontrib><creatorcontrib>Luna, Adrián</creatorcontrib><creatorcontrib>Krötzsch, Fernando Edgar</creatorcontrib><title>Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Background. Adhesion formation in the peritoneal cavity is the most common cause of intestinal obstruction and secondary female infertility. A great effort has been dedicated to reduce adhesion formation because of the associated morbidity and its complications.
Materials and methods. This study was designed as a before-after comparative trial and included 14 rabbits, with a weight between 300 and 500 g. All rabbits were appendectomized and 1 month later laparotomized to assess adhesion formation. Rabbits were randomized into two groups, Group I (control group), with no intervention, and Group II (experimental group), treated with an intraperitoneal sponge of collagen-polyvinylpyrrolidone (Clg-PVP). The laparotomy procedure was repeated 1 month later for a new assessment of adhesion formation and histological evaluation by H-E and Masson staining.
Results. Histological findings showed abundant infiltrate in the control group, which was mild in the experimental group. With the Masson stain the control group showed a significantly higher amount of collagen than the experimental group and the fibrous tissue was more compact. We found a mean number of adhesions of 3.29 ± 1.98 for the control group, which decreased to 2.57 ± 0.79 after the second laparotomy. For the experimental group the mean number of adhesions decreased from 1.86 ± 0.90 to 0.71 ± 0.49 after the second laparotomy, with no statistical difference between both groups before Clg-PVP application, but a significant statistical difference after the implantation of Clg-PVP (Student’s
t test;
P < 0.001, two-tailed).
Conclusion. Collagen-polyvinylpyrrolidone decreases the incidence and size of intraabdominal adhesions after secondary adhesion formation after appendectomy.</description><subject>Animals</subject><subject>appendectomy</subject><subject>Appendectomy - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Collagen - antagonists & inhibitors</subject><subject>Collagen - biosynthesis</subject><subject>Collagen - therapeutic use</subject><subject>collagen-polyvinylpyrrolidone</subject><subject>Female</subject><subject>intraperitoneal adhesions</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peritoneal Diseases - etiology</subject><subject>Peritoneal Diseases - pathology</subject><subject>Peritoneal Diseases - prevention & control</subject><subject>Peritoneal Diseases - surgery</subject><subject>Povidone - therapeutic use</subject><subject>Rabbits</subject><subject>Secondary Prevention</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Tissue Adhesions - etiology</subject><subject>Tissue Adhesions - pathology</subject><subject>Tissue Adhesions - prevention & control</subject><subject>Tissue Adhesions - surgery</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFr1EAQxxdR7Fn9CEpeLBYand1NstknKYdthYIVi6_LZnaiK7nsuZMr9Nub6wX72Kdh4Df_GX4jxFsJHyXI5tMPAKXKqoXqA6hTALC2tM_ESoKty7Yx-rlY_UeOxCvmPzOkrNEvxZFUjTUVqJX4vk7D4H_RWN78vDkrfIFLX_D9OP0mjlxsUtgNfkr5rAiEmTwTF3Gcst9SjlMayQ-FD3s4jfxavOj9wPRmqcfi9uLL7fqqvP52-XV9fl2ihmYqEUkbbUHJXmPfeotBSuhM0LXx3na1wUa3VYM2YE2mrshI1ctKgtJt1-ljcXKI3eb0d0c8uU1kpPn4kdKOndEKKl3LGawPIObEnKl32xw3Pt87CW6v0j2odHtPDpR7UOnsPPduWbDrNhQepxZ3M_B-ATyjH_rsR4z8yFVmfoXZB30-cDTbuIuUHWOkESnETDi5kOITp_wDbS-QNA</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>Cervantes-Sánchez, Carlos R</creator><creator>Olaya, Enrique</creator><creator>Testas, Manuel</creator><creator>Garcia-López, Norberto</creator><creator>Coste, Gabriel</creator><creator>Arrellin, Gerardo</creator><creator>Luna, Adrián</creator><creator>Krötzsch, Fernando Edgar</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions</title><author>Cervantes-Sánchez, Carlos R ; Olaya, Enrique ; Testas, Manuel ; Garcia-López, Norberto ; Coste, Gabriel ; Arrellin, Gerardo ; Luna, Adrián ; Krötzsch, Fernando Edgar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-cce3739021f3cf8a9cd110b7d357aa9b57c63846c9dc5e754e712f1410238bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>appendectomy</topic><topic>Appendectomy - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Collagen - antagonists & inhibitors</topic><topic>Collagen - biosynthesis</topic><topic>Collagen - therapeutic use</topic><topic>collagen-polyvinylpyrrolidone</topic><topic>Female</topic><topic>intraperitoneal adhesions</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peritoneal Diseases - etiology</topic><topic>Peritoneal Diseases - pathology</topic><topic>Peritoneal Diseases - prevention & control</topic><topic>Peritoneal Diseases - surgery</topic><topic>Povidone - therapeutic use</topic><topic>Rabbits</topic><topic>Secondary Prevention</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Tissue Adhesions - etiology</topic><topic>Tissue Adhesions - pathology</topic><topic>Tissue Adhesions - prevention & control</topic><topic>Tissue Adhesions - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cervantes-Sánchez, Carlos R</creatorcontrib><creatorcontrib>Olaya, Enrique</creatorcontrib><creatorcontrib>Testas, Manuel</creatorcontrib><creatorcontrib>Garcia-López, Norberto</creatorcontrib><creatorcontrib>Coste, Gabriel</creatorcontrib><creatorcontrib>Arrellin, Gerardo</creatorcontrib><creatorcontrib>Luna, Adrián</creatorcontrib><creatorcontrib>Krötzsch, Fernando Edgar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cervantes-Sánchez, Carlos R</au><au>Olaya, Enrique</au><au>Testas, Manuel</au><au>Garcia-López, Norberto</au><au>Coste, Gabriel</au><au>Arrellin, Gerardo</au><au>Luna, Adrián</au><au>Krötzsch, Fernando Edgar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2003-03</date><risdate>2003</risdate><volume>110</volume><issue>1</issue><spage>207</spage><epage>210</epage><pages>207-210</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><coden>JSGRA2</coden><abstract>Background. Adhesion formation in the peritoneal cavity is the most common cause of intestinal obstruction and secondary female infertility. A great effort has been dedicated to reduce adhesion formation because of the associated morbidity and its complications.
Materials and methods. This study was designed as a before-after comparative trial and included 14 rabbits, with a weight between 300 and 500 g. All rabbits were appendectomized and 1 month later laparotomized to assess adhesion formation. Rabbits were randomized into two groups, Group I (control group), with no intervention, and Group II (experimental group), treated with an intraperitoneal sponge of collagen-polyvinylpyrrolidone (Clg-PVP). The laparotomy procedure was repeated 1 month later for a new assessment of adhesion formation and histological evaluation by H-E and Masson staining.
Results. Histological findings showed abundant infiltrate in the control group, which was mild in the experimental group. With the Masson stain the control group showed a significantly higher amount of collagen than the experimental group and the fibrous tissue was more compact. We found a mean number of adhesions of 3.29 ± 1.98 for the control group, which decreased to 2.57 ± 0.79 after the second laparotomy. For the experimental group the mean number of adhesions decreased from 1.86 ± 0.90 to 0.71 ± 0.49 after the second laparotomy, with no statistical difference between both groups before Clg-PVP application, but a significant statistical difference after the implantation of Clg-PVP (Student’s
t test;
P < 0.001, two-tailed).
Conclusion. Collagen-polyvinylpyrrolidone decreases the incidence and size of intraabdominal adhesions after secondary adhesion formation after appendectomy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12697402</pmid><doi>10.1016/S0022-4804(02)00099-9</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals appendectomy Appendectomy - adverse effects Biological and medical sciences Collagen - antagonists & inhibitors Collagen - biosynthesis Collagen - therapeutic use collagen-polyvinylpyrrolidone Female intraperitoneal adhesions Male Medical sciences Peritoneal Diseases - etiology Peritoneal Diseases - pathology Peritoneal Diseases - prevention & control Peritoneal Diseases - surgery Povidone - therapeutic use Rabbits Secondary Prevention Stomach, duodenum, intestine, rectum, anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tissue Adhesions - etiology Tissue Adhesions - pathology Tissue Adhesions - prevention & control Tissue Adhesions - surgery |
| title | Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions |
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