Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53

Wild-type p53 protein was shown to bind specifically to DNA sequences within SV40 (Bargonetti et al. 1991), the human ribosomal gene cluster (RGC) (Kern et al. 1991a), and the murine muscle creatine kinase gene (MCK) (Zambetti et al. 1992). However, a direct comparison of these three sites was not p...

Ausführliche Beschreibung