Loss of collagen type VI from rat endometrial stroma during decidualization
The expression of collagen type VI in the extracellular matrix of rat uterine endometrial stroma after a decidual stimulus was examined by immunolocalization and immunoblotting. The intermediate filament protein, desmin, was used as a marker to identify decidual cells. Tissue was examined from pregn...
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| Veröffentlicht in: | Biology of reproduction 1992-06, Vol.46 (6), p.1136-1143 |
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| container_title | Biology of reproduction |
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| creator | MULHOLLAND, J APLIN, J. D AYAD, S HONG, L GLASSER, S. R |
| description | The expression of collagen type VI in the extracellular matrix of rat uterine endometrial stroma after a decidual stimulus
was examined by immunolocalization and immunoblotting. The intermediate filament protein, desmin, was used as a marker to
identify decidual cells. Tissue was examined from pregnant animals and from ovariectomized, hormone-treated rats in which
decidualization had been induced artificially. In undifferentiated tissue from both groups of animals, collagen type VI was
abundant, and desmin was present only in vascular smooth muscle cells. By 72 h after a decidual stimulus, however, collagen
type VI had essentially disappeared from the matrix of the antimesometrial stromal compartment, and desmin was highly expressed
in the decidualizing cells. During regression of the decidual tissue, collagen type VI began to reappear in the stromal matrix,
whereas desmin expression declined as decidual cells degenerated. These results indicate that remodeling of the uterine extracellular
matrix in response to embryo implantation is a function of the differentiating decidual cell. |
| doi_str_mv | 10.1095/biolreprod46.6.1136 |
| format | Article |
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was examined by immunolocalization and immunoblotting. The intermediate filament protein, desmin, was used as a marker to
identify decidual cells. Tissue was examined from pregnant animals and from ovariectomized, hormone-treated rats in which
decidualization had been induced artificially. In undifferentiated tissue from both groups of animals, collagen type VI was
abundant, and desmin was present only in vascular smooth muscle cells. By 72 h after a decidual stimulus, however, collagen
type VI had essentially disappeared from the matrix of the antimesometrial stromal compartment, and desmin was highly expressed
in the decidualizing cells. During regression of the decidual tissue, collagen type VI began to reappear in the stromal matrix,
whereas desmin expression declined as decidual cells degenerated. These results indicate that remodeling of the uterine extracellular
matrix in response to embryo implantation is a function of the differentiating decidual cell.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod46.6.1136</identifier><identifier>PMID: 1391311</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Collagen - metabolism ; Decidua - physiology ; Desmin - analysis ; Desmin - metabolism ; Embryo Implantation - physiology ; Endometrium - metabolism ; Extracellular Matrix - metabolism ; Female ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Immunoblotting ; Mammalian female genital system ; Morphology. Physiology ; Ovariectomy ; Pregnancy ; Rats ; Rats, Inbred F344 ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 1992-06, Vol.46 (6), p.1136-1143</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5317851$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1391311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MULHOLLAND, J</creatorcontrib><creatorcontrib>APLIN, J. D</creatorcontrib><creatorcontrib>AYAD, S</creatorcontrib><creatorcontrib>HONG, L</creatorcontrib><creatorcontrib>GLASSER, S. R</creatorcontrib><title>Loss of collagen type VI from rat endometrial stroma during decidualization</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The expression of collagen type VI in the extracellular matrix of rat uterine endometrial stroma after a decidual stimulus
was examined by immunolocalization and immunoblotting. The intermediate filament protein, desmin, was used as a marker to
identify decidual cells. Tissue was examined from pregnant animals and from ovariectomized, hormone-treated rats in which
decidualization had been induced artificially. In undifferentiated tissue from both groups of animals, collagen type VI was
abundant, and desmin was present only in vascular smooth muscle cells. By 72 h after a decidual stimulus, however, collagen
type VI had essentially disappeared from the matrix of the antimesometrial stromal compartment, and desmin was highly expressed
in the decidualizing cells. During regression of the decidual tissue, collagen type VI began to reappear in the stromal matrix,
whereas desmin expression declined as decidual cells degenerated. These results indicate that remodeling of the uterine extracellular
matrix in response to embryo implantation is a function of the differentiating decidual cell.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Collagen - metabolism</subject><subject>Decidua - physiology</subject><subject>Desmin - analysis</subject><subject>Desmin - metabolism</subject><subject>Embryo Implantation - physiology</subject><subject>Endometrium - metabolism</subject><subject>Extracellular Matrix - metabolism</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunoblotting</subject><subject>Mammalian female genital system</subject><subject>Morphology. Physiology</subject><subject>Ovariectomy</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUMtOwzAQtBColMIXICQfELcUr-04yRFVPCoqcQGu0SZxWiMnLnaiqnw9RlRw2tXMaHZmCbkENgdWpLeVcdbrrXeNVHM1BxDqiEwh5UWScZUfkyljTCVCKHFKzkL4YAyk4GJCJiAKEABT8rxyIVDX0tpZi2vd02G_1fR9SVvvOupxoLpvXKcHb9DSMEQUaTN6069po2vTjGjNFw7G9efkpEUb9MVhzsjbw_3r4ilZvTwuF3erZMOVGhINMUMhmVRtBk0hsNYtVKrKMFc8byGLHOaYi5SjZFmlIpIyHtdMgmqkmJGbX99Y_XPUYSg7E2od8_fajaHMBGfApYjCq4NwrDrdlFtvOvT78tA-8tcHHkONtvXY1yb8yVIBWZ7C_72NWW92xusydGhtNBXlbreTqlTlz_PFN1f_dt0</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>MULHOLLAND, J</creator><creator>APLIN, J. D</creator><creator>AYAD, S</creator><creator>HONG, L</creator><creator>GLASSER, S. R</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19920601</creationdate><title>Loss of collagen type VI from rat endometrial stroma during decidualization</title><author>MULHOLLAND, J ; APLIN, J. D ; AYAD, S ; HONG, L ; GLASSER, S. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-e132394046f71d93acef1b6b7a8628f17940a8a8352a407b61795024077416d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Collagen - metabolism</topic><topic>Decidua - physiology</topic><topic>Desmin - analysis</topic><topic>Desmin - metabolism</topic><topic>Embryo Implantation - physiology</topic><topic>Endometrium - metabolism</topic><topic>Extracellular Matrix - metabolism</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunoblotting</topic><topic>Mammalian female genital system</topic><topic>Morphology. Physiology</topic><topic>Ovariectomy</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MULHOLLAND, J</creatorcontrib><creatorcontrib>APLIN, J. D</creatorcontrib><creatorcontrib>AYAD, S</creatorcontrib><creatorcontrib>HONG, L</creatorcontrib><creatorcontrib>GLASSER, S. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MULHOLLAND, J</au><au>APLIN, J. D</au><au>AYAD, S</au><au>HONG, L</au><au>GLASSER, S. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of collagen type VI from rat endometrial stroma during decidualization</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>46</volume><issue>6</issue><spage>1136</spage><epage>1143</epage><pages>1136-1143</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>The expression of collagen type VI in the extracellular matrix of rat uterine endometrial stroma after a decidual stimulus
was examined by immunolocalization and immunoblotting. The intermediate filament protein, desmin, was used as a marker to
identify decidual cells. Tissue was examined from pregnant animals and from ovariectomized, hormone-treated rats in which
decidualization had been induced artificially. In undifferentiated tissue from both groups of animals, collagen type VI was
abundant, and desmin was present only in vascular smooth muscle cells. By 72 h after a decidual stimulus, however, collagen
type VI had essentially disappeared from the matrix of the antimesometrial stromal compartment, and desmin was highly expressed
in the decidualizing cells. During regression of the decidual tissue, collagen type VI began to reappear in the stromal matrix,
whereas desmin expression declined as decidual cells degenerated. These results indicate that remodeling of the uterine extracellular
matrix in response to embryo implantation is a function of the differentiating decidual cell.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>1391311</pmid><doi>10.1095/biolreprod46.6.1136</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biology of reproduction, 1992-06, Vol.46 (6), p.1136-1143 |
| issn | 0006-3363 1529-7268 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Collagen - metabolism Decidua - physiology Desmin - analysis Desmin - metabolism Embryo Implantation - physiology Endometrium - metabolism Extracellular Matrix - metabolism Female Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Immunoblotting Mammalian female genital system Morphology. Physiology Ovariectomy Pregnancy Rats Rats, Inbred F344 Vertebrates: reproduction |
| title | Loss of collagen type VI from rat endometrial stroma during decidualization |
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