Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses

A search has been initiated for lead inhibitors of the nonstructural protein 3 (NS3)‐associated NTPase/helicase activities of hepatitis C virus, the related West Nile virus, Japanese encephalitis virus and the human mitochondrial Suv3 enzyme. Random screening of a broad range of unrelated low‐molecu...

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Veröffentlicht in:	European journal of biochemistry 2003-04, Vol.270 (8), p.1645-1653
Hauptverfasser:	Borowski, Peter, Deinert, Johanna, Schalinski, Sarah, Bretner, Maria, Ginalski, Krzysztof, Kulikowski, Tadeusz, Shugar, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases - antagonists & inhibitors Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphatases - chemistry Antiviral Agents - pharmacology Benzimidazoles - pharmacology Binding Sites DNA Helicases - antagonists & inhibitors halogenated benzimidazoles/benzotriazoles Hepacivirus - drug effects Hepacivirus - enzymology hepatitis C and related viruses inhibitors Kinetics Models, Molecular NTPase/helicases Nucleoside-Triphosphatase Protein Conformation Substrate Specificity Triazoles - pharmacology Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - chemistry
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