Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats

Young and aged rats were subjected to cerebrovascular insufficiency (CVI) for 3 and 9 weeks. At the end of each time period, local cerebral blood flow (ICBF), spatial memory function, 31P- and 1H-NMR spectroscopy and imaging of the brains were evaluated in vivo. Morphometric counts of CA1 hippocampa...

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Veröffentlicht in:	Brain research 1992-06, Vol.582 (2), p.186-195
Hauptverfasser:	dela Torre, J.C., Fortin, T., Park, G.A.S., Butler, K.S., Kozlowski, P., Pappas, B.A., de Socarraz, H., Saunders, J.K., Richard, M.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	1H-NMR microimaging 31P-NMR spectroscopy Aging - pathology Alzheimer's disease Animals Biological and medical sciences Brain Ischemia - complications Brain Ischemia - pathology Brain Ischemia - physiopathology CA1 sector Cerebral blood flow Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cerebrovascular Circulation - physiology Cerebrovascular insufficiency Chronic Disease Dementia, Vascular - etiology Dementia, Vascular - pathology Hippocampus Hippocampus - pathology Hippocampus - physiopathology Ischemia Magnetic Resonance Spectroscopy Male Medical sciences Memory Memory Disorders - etiology Nervous system involvement in other diseases. Miscellaneous Neurology Phosphomonoester Phosphorus Protons Rats Rats, Sprague-Dawley Spatial Behavior
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